An article Amide Synthesis through the In Situ Generation of Chloro- and Imido-Phosphonium Salts WOS:000546100300092 published article about N-C CLEAVAGE; CARBOXYLIC-ACIDS; CATALYZED AMINOCARBONYLATION; AMINO-ACIDS; OXIDATIVE AMIDATION; FREE TRANSAMIDATION; SECONDARY AMIDES; ARYL IODIDES; METAL-FREE; ALDEHYDES in [Irving, Charles D.; Floreancig, Jack T.; Laulhe, Sebastien] Indiana Univ Purdue Univ Indianapolis IUPUI, Dept Chem & Chem Biol, Indianapolis, IN 46202 USA in 2020, Cited 84. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7
We describe a methodology for the amidation of carboxylic acids by generating phosphonium salts in situ from N-chlorophthalimide and triphenylphosphine. Aliphatic, benzylic, and aromatic carboxylic acids can be transformed into their amide counter parts using primary and secondary amines. This functional group interconversion is achieved at room temperature in good to excellent yields. Mechanistic work shows the in situ formation of chloro- and imido-phosphonium salts that react as activating agents for carboxylic acids and generate an acyloxyphosphonium species.
Application In Synthesis of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Irving, CD; Floreancig, JT; Laulhe, S or send Email.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem