Quality Control of 4-Nitrobenzoic acid. Recently I am researching about ESCHERICHIA-COLI; MICROCYSTIS-AERUGINOSA; ANTIFUNGAL ACTIVITY; RATIONAL DESIGN; DERIVATIVES; COMPONENT; ENZYME; GENES, Saw an article supported by the National Research and Development Plan [2017YFD0200506]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21877047, 21472062, 21877046, 21867011, 21472061, 31701820]; Project of the Science Fund of Jiangxi Education Office [GJJ170672]; Project of Hubei Natural Science Foundation [2017CFB232]; China postdoctoral science foundationChina Postdoctoral Science Foundation [2017M622486]; self-determined research funds of CCNU from the colleges’ basic research and operation of MOE [CCNU18ZDPY02]; Program of Introducing Talents of Discipline to Universities of China (111 program) [B17019]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Feng, JT; He, HF; Zhou, Y; Guo, XL; Liu, HL; Cai, M; Wang, F; Feng, LL; He, HW. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid
Cyanobacterial pyruvate dehydrogenase multienzyme complex E1 (PDHc E1) is a potential target enzyme for finding inhibitors to control harmful cyanobacterial blooms. In this study, a series of novel triazole thiamin diphosphate (ThDP) analogs were designed and synthesized by modifying the substituent group of triazole ring and optimizing triazole-benzene linker as potential cyanobacterial PDHc E1 (Cy-PDHc E1) inhibitors. Their inhibitory activities against Cy-PDHc E1 in vitro and algicide activities in vivo were further examined. Most of these compounds exhibited prominent inhibitory activities against Cy-PDHc E1 (IC50 1.48-4.48 mu M) and good algicide activities against Synechocystis PCC6803 (EC50 0.84-2.44 mu M) and Microcystis aeruginosa FACHB905 (EC50 0.74-1.77 mu M). Especially, compound 8d showed not only the highest inhibitory activity against Cy-PDHc E1 (IC50 1.48 mu M), but also the most powerful inhibitory selectivity between Cy-PDHc E1 (inhibitory rate 98.90%) and porcine PDHc E1 (inhibitory rate only 9.54%). Furthermore, the potential interaction between compound 8d and Cy-PDHc E1 was analyzed by a molecular docking method and site-directed mutagenesis and enzymatic analysis and fluorescence spectral analysis. These results indicated that compound 8d could be used as a hit compound for further optimization and might have potential to be developed as a new algicide.
Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Feng, JT; He, HF; Zhou, Y; Guo, XL; Liu, HL; Cai, M; Wang, F; Feng, LL; He, HW or send Email.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem