Some tips on 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid

42972-13-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid, cas is 42972-13-4,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

l-Bromo-4-oxo-3,4-dihydro-phthalazine-6-carboxylic acidl,4-Dioxo-l,2,3,4-tetrahydro-phthalazine-6-carboxylic acid (91.Og, 0.44mol) was suspended in dichloroethane (1.0L) and phosphorus pentabromide (761.Og,1.77mol) was added in three portions and the reaction heated to reflux for 24 hours. The reaction was cooled to room temperature and poured onto ice (2.50kg) EPO and the resulting precipitate filtered and washed with water to give the crude product (13Og).This crude material was suspended in acetic acid (1.60L) and heated to 125C for 2 hours. The reaction was cooled to room temperature and poured onto ice (1.5kg) and the resulting precipitate filtered. The solid was washed with water and dried to give the title compound (85g, 73% yield) as a yellow solid. MS (ESI+) = (M+H)+ 310 & 312

The chemical industry reduces the impact on the environment during synthesis,42972-13-4,1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2006/32518; (2006); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem