As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazine, and cas is 253-52-1, its synthesis route is as follows.
28.1. Preparation of 1-furan-2-yl-1,2-dihydrophthalazine 22.5 ml of an about 1.6M solution of butyllithium are slowly added dropwise at -78¡ã C. to a solution of 2.46 g of furan in 30 ml of tetrahydrofuran. The mixture is stirred at -78¡ã C. for 20 min., then at -20¡ã C. for 2 hrs. The solution is again cooled to -78¡ã C. and treated slowly with a solution of 4.68 g of phthalazine in 36 ml of tetrahydrofuran. The mixture is stirred at -78¡ã C. for 2 hrs., then poured on to about 500 ml of ice-water and extracted 4 times with 150 ml of ethyl acetate each time. The organic phases are dried, concentrated and the residue is chromatographed immediately on 120 g of silica gel; eluent: hexane/ethyl acetate 3:7. 4.08 g of dark, impure 1-furan-2-yl-1,2-dihydrophthalazine are isolated. The following compounds of formula IV are prepared in analogy to Example 28.1.:
253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see
Reference£º
Patent; Hoffmann-La Roche Inc.; US6114330; (2000); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem