An article Novel 12-hydroxydehydroabietylamine derivatives act as potent and selective butyrylcholinesterase inhibitors WOS:000479184600035 published article about CHOLINESTERASE-INHIBITORS; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE INHIBITORS; CARBONIC-ANHYDRASE; DEMENTIA in [Loesche, Anne; Wiemann, Jana; Rohmer, Matthias; Csuk, Rene] Martin Luther Univ Halle Wittenberg, Organ Chem, Kurt Mothes Str 2, D-06120 Halle, Saale, Germany; [Brandt, Wolfgang] Leibniz Inst Plant Biochem, Bioorgan Chem, Weinberg 3, D-06120 Halle, Saale, Germany in 2019, Cited 22. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7
The skeleton of the diterpene dehydroabietylamine was modified, and a set of 12-hydroxy-dehydroabietylamine derivatives was obtained. The compounds were screened in colorimetric Ellman’s assays to determine their ability to act as inhibitors for the enzymes acetylcholinesterase (AChE, from electric eel) and butyrylcholinesterase (BChE, from equine serum). Additional investigations concerning the enzyme kinetics were performed and showed 12-hydroxy-N-(4-nitro-benzoyl)dehydroabietylamine (13) and 12-hydroxy-N-(isonicotinoyl)dehydroabietylamine (17) as selective BChE inhibitors holding good inhibition constants K-i = 0.72 +/- 0.06 mu M and K-i = 0.86 +/- 0.19 mu M, respectively.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem