Safety of 4-Nitrobenzoic acid. Shen, SQ; Dong, LL; Lu, HZ; Dong, YH; Yang, Q; Zhang, JJ in [Shen, Shengqiang; Dong, Lili; Lu, Huizhe; Dong, Yanhong; Zhang, Jianjun] China Agr Univ, Coll Sci, Dept Pesticide Chem, Beijing, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, Shenzhen Agr Genome Res Inst, Beijing, Peoples R China published Synthesis of ureido thioglycosides as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors in 2020.0, Cited 24.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.
The insect beta-N-acetylhexosaminidase OfHex1 from Ostrinia furnacalis (one of the most destructive agricultural pests) has been considered as a promising pesticide target. In this study, a series of novel and readily available ureido thioglycosides were designed and synthesized based on the catalytic mechanism and the co-crystal structures of OfHex1 with substrates. After evaluation via enzyme inhibition experiments, thioglycosides 11c and 15k were found to have inhibitory activities against OfHex1 with the K-i values of 25.6 mu M and 53.8 mu M, respectively. In addition, all these ureido thioglycosides exhibited high selectivity toward OfHex1 over hOGA and HsHexB (K-i > 100 mu M). Furthermore, to investigate the inhibitory mechanism, the possible binding modes of 11c and 15k with OfHex1 were deduced based on molecular docking analysis. This work may provide useful structural starting points for further rational design of potent inhibitors of OfHex1.
Welcome to talk about 62-23-7, If you have any questions, you can contact Shen, SQ; Dong, LL; Lu, HZ; Dong, YH; Yang, Q; Zhang, JJ or send Email.. Safety of 4-Nitrobenzoic acid
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem