Application In Synthesis of 4-Nitrobenzoic acid. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Chemical modifications of G418 (geneticin): Synthesis of novel readthrough aminoglycosides results in an improved in vitro safety window but no improvements in vivo published in 2020.0, Reprint Addresses Baiazitov, RY (corresponding author), PTC Therapeut Inc, 100 Corp Court, South Plainfield, NJ 07080 USA.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.
G418 is currently the most potent and active aminoglycoside to promote readthrough of eukaryotic nonsense mutations. However, owing to its toxicity G418 cannot be used in vivo to study readthrough activity A robust and scalable method for selective derivatization of G418 was developed to study the biological activity and toxicity of a series of analogs. Despite our synthetic efforts, an improvement in readthrough potency was not achieved. We discovered several analogs that demonstrated reduced zebra fish hair cell toxicity (a surrogate for ototoxicity), but this reduction in cellular toxicity did not translate to reduced in vivo toxicity in rats.
Application In Synthesis of 4-Nitrobenzoic acid. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem