In 2020 ACS COMB SCI published article about SOLUTION-PHASE SYNTHESIS; POLYMER-SUPPORTED REAGENTS; PEPTIDE-SYNTHESIS; PARALLEL SYNTHESIS; CRYSTAL-STRUCTURES; LIBRARY SYNTHESIS; INHIBITORS; SCAVENGERS; RACEMIZATION; CATALYSTS in [Dankers, Christian; Tadros, Joseph; Aldrich-Wright, Janice R.; Gordon, Christopher P.] Western Sydney Univ, Sch Sci, Sydney, NSW 1797, Australia; [Gordon, Christopher P.] Western Sydney Univ, Sch Med, Mol Med Res Grp, Sydney, NSW 1797, Australia; [Harman, David G.] Western Sydney Univ, Sch Med, Campbelltown, NSW 2560, Australia; [Harman, David G.] Western Sydney Univ, Sch Med, Mol Med Res Grp, Campbelltown, NSW 2560, Australia; [Aldrich-Wright, Janice R.] Western Sydney Univ, Nanoscale Org & Dynam Grp, Sydney, NSW 1797, Australia; [Nguyen, Thanh, V] Univ New South Wales, Sch Chem, Sydney, NSW 2052, Australia in 2020, Cited 53. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7
Through a screen of over one hundred and 30 permutations of reaction temperatures, solvents, carbodiimide resins, and carbodiimide molar equivalences, in the presence, absence, or combination of diisopropylamine and benzotriazole additives, a convenient and first reported carbodiimide polymer-assisted flow approach to effect amide coupling and lactamization was developed. The protocol entails injecting a single solution (1:9 dimethylformamide: dichloromethane) containing a carboxylic acid and an amine or linear peptide sequence into a continuous stream of dichloromethane. The protocol remained viable in the absence of base, did not require carboxylate preactivation which, and in concert with minimal workup requirements, enabled the isolation of products in high yields. Compared to the utilization of untethered carbodiimide reagents, the flow procedure was also observed to provide a degree of racemization safety.
Product Details of 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem