In 2020 EUR J MED CHEM published article about ALZHEIMERS-DISEASE; OXIDATIVE STRESS; CELECOXIB; DESIGN; APOPTOSIS; ACID; MICE in [Liao, Liping; Jiang, Caibao; Chen, Jianwen; Shi, Jinguo; Li, Xinhua; Wang, Yang; Wen, Jin; Zhou, Shujia; Liang, Jie; Lao, Yaoqiang; Zhang, Jingxia] Sun Yat Sen Univ, Sch Pharmaceut Sci, Dept Med Chem, Guangzhou 510006, Peoples R China in 2020, Cited 46. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 4-Nitrobenzoic acid
A series of 1,2,4-triazole derivatives 1-14 was synthesized to investigate their neuroprotective effects and mechanisms of action. Compounds 5-11 noticeably protected PC12 cells from the cytotoxicity of H2O2 or sodium nitroprusside (SNP). Compound 11 was the most effective derivative. Compound 11 chelated Fe (II) iron, scavenged reactive oxygen species (ROS), and restored the mitochondrial membrane potential (MMP). Moreover, it enhanced the activity of the antioxidant defense system by increasing the serum level of superoxide dismutase (SOD) and promoting the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). Compound 11 caused certain improvements in behavior, the cerebral infarction area, and serum levels of biochemical indicators (TNF-alpha, IL-10, SOD and MDA) in a rat MCAO model. The lethal dose (LD50) of compound 11 in mice receiving intraperitoneal injections was greater than 400 mg/kg. Meanwhile, pharmacokinetic experiments revealed high bioavailability of this compound after both oral and intravenous administration (F = 60.76%, CL = 0.014 mg/kg/h) and a longer half-life (4.26 and 5.11 h after oral and intravenous administration, respectively). Based on these findings, compound 11 may be a promising neuroprotectant for the treatment of ischemic stroke. (C) 2020 Elsevier Masson SAS. All rights reserved.
Welcome to talk about 62-23-7, If you have any questions, you can contact Liao, LP; Jiang, CB; Chen, JW; Shi, JG; Li, XH; Wang, Y; Wen, J; Zhou, SJ; Liang, J; Lao, YQ; Zhang, JX or send Email.. Recommanded Product: 4-Nitrobenzoic acid
Reference:
Phthalazine – Wikipedia,
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