152265-57-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7-Bromophthalazin-1(2H)-one, cas is 152265-57-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.
Example 807-(4-(trifluoromethoxy)phenyl)phthalazin-1(2H)-one (Compound III-1) A mixture of 7-bromophthalazinone (1.09 g, 4.84 mmol), 4-trifluoromethoxyphenyl boronic acid (1.20 g, 5.81 mmol), dppf(Pd)Cl2 (177 mg, 0.242 mmol), potassium carbonate (1.34 g, 9.68 mmol) in degassed toluene (4 mL), degassed water (2 mL) and degassed isopropanol (2 mL) was heated at 90 C. for 12 hours. The layers were separated, the organic layer was concentrated and the residue was purified by trituration with hexanes/ethyl acetate to provide 7-(4-(trifluoromethoxy)phenyl)phthalazin-1(2H)-one as a white powder. C15H9F3N2O2. 307.2 (M+1).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7-Bromophthalazin-1(2H)-one, 152265-57-1
Reference£º
Patent; Gilead Sciences, Inc.; US2012/289493; (2012); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem