In 2019 EUR J MED CHEM published article about SM PROTEINS; PRMT5; METHYLATION; GROWTH; IDENTIFICATION; COMPLEX; PICLN in [Shao, Jingwei; Duan, Wenhu] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China; [Zhu, Kongkai; Tao, Hongrui] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China; [Du, Daohai; Zhang, Yuanyuan; Tao, Hongrui; Chen, Zhifeng; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res,State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Chen, Kaixian; Luo, Cheng] Qingdao Natl Lab Marine Sci & Technol, Open Studio Drugabil Res Marine Nat Prod, Wenhai Rd, Qingdao 266237, Shandong, Peoples R China in 2019, Cited 36. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4
Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a series of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)amide derivatives targeting PRMT5 were designed with structure-based approach and synthesized. Among them, compound 46 showed potent and selective PRMT5 inhibition activity with an IC50 of 8.5 nM, which was approximately equivalent with the phase 1 clinical trial PRMT5 inhibitor GSK-3326595 (IC50 = 5.5 nM). Compound 46 also displayed pronounced anti-proliferative activity in MV4-11 cells (GI(50) =18 nM) and antitumor activity in MV4-11 mouse xenografts model. This molecule can serve as an excellent tool compound for probing the biological function of PRMT5. (C) 2018 Published by Elsevier Masson SAS.
Welcome to talk about 62-23-7, If you have any questions, you can contact Shao, JW; Zhu, KK; Du, DH; Zhang, YY; Tao, HR; Chen, ZF; Jiang, HL; Chen, KX; Luo, C; Duan, WH or send Email.. COA of Formula: C7H5NO4
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem