Biological active acylhydrazide I. The O-acyl derivatives nature of monoacylation products of cyclic maleic- and phthalic-hydrazide was written by Panea, I.;Bodochi, Lucia;Panea, Teodora;Zinveliu, Daniela;Pascalau, Violeta. And the article was included in Southern Brazilian Journal of Chemistry in 1999.Reference of 18393-54-9 This article mentions the following:
It was confirmed, on the basis of chem. and physico-chem. (m.ps., IR and 1H-NMR spectra) data, that the products formed by monoacylation of cyclic maleic and phthalic acid hydrazides are the O-acyl derivatives, although owing to tautomerism, these hydrazides may form N- or/and O-acyl derivatives in such reactions. Simultaneously, it was shown that claims of formation of N-acyl derivatives of cyclic maleic and phthalic acid hydrazides were not valid. Also by reacting the cyclic maleic and phthalic acid hydrazide with 4-chlorobenzoyl chloride two new O-monoacyl derivatives [3-(4-chlorobenzoyloxy)-1-H-pyridazin-6-one and 1-(4-chlorobenzoyloxy)-3-H-phthalazin-1-one] were obtained. In the experiment, the researchers used many compounds, for example, 2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9Reference of 18393-54-9).
2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9) belongs to phthalazine derivatives. Phthalazines, as an important class of bicyclic N-heterocycles, have attracted sizable attention due to their valuable biological and pharmacological activities. New methods for the functionalization of pyridazine, phthalazine, and cinnoline rings emerged in 2016. Buchwald and his group devised an asymmetric hydroarylation of vinylarenes.Reference of 18393-54-9
Referemce:
Phthalazine – Wikipedia,
Phthalazine | C8H6N2 – PubChem