Central nervous system active compounds. XI. 1-(3-Phthalidyl)phthalazin-4-ones was written by Prager, Rolf;Ward, A. David;Marshall, Philip;Mooney, Brett. And the article was included in Heterocycles in 1982.Formula: C9H8N2O2 This article mentions the following:
Phthalidylphthalazinones I (R = H, Me, Et; R1, R6 = H; R1R2, R5R6 = OCH2O; R2 = H, OMe, Me, NO2; R3 = H, Me, OMe; R4, R5 = H, OMe, Cl) can be readily prepared by the reaction of hydrazines with the corresponding biphthalide. The reaction with unsym. biphthalides appears to be controlled mainly by electronic factors. Phthalidylphthalazinone undergoes the Mannich reaction leading to a 3-substituted product. 1-Chlorophthalazine reacts with BuLi by addition at C-4; the resulting anion is alkylated at C-3 with 2-HCOC6H4CO2Me. The compounds cause loss of muscular control in mice, but their insolubility hinders further pharmacol. investigation. In the experiment, the researchers used many compounds, for example, 2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9Formula: C9H8N2O2).
2-Methyl-2,3-dihydrophthalazine-1,4-dione (cas: 18393-54-9) belongs to phthalazine derivatives. Although, N-containing heterocyclic compounds are widely distributed in nature, the presence of two adjacent nitrogen atoms in the phthalazine ring makes it rare and not very familiar in isolated extracts from living organisms. Phthalazines are popular pharmacophores as they are the core chemical motifs in many commercially available drugs such as Azelastin (antihistamine), Vatalanib (vascular endothelial growth factor receptor (VEGFR) inhibitor), and Hydralazine (antihypertensive agent).Formula: C9H8N2O2
Referemce:
Phthalazine – Wikipedia,
Phthalazine | C8H6N2 – PubChem