Synthesis and anti-tumor activity of 1-(4-chloroaniline)-4-(4-pyridylmethyl)-2,3-benzodiazine succinate was written by Chen, Guanhong;Wang, Jianing;Kong, Xue;Liu, Kechun. And the article was included in Yingyong Huaxue in 2011.Safety of N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine This article mentions the following:
1-(4-Chloroaniline)-4-(4-pyridylmethyl)-2,3-benzodiazine succinate I was synthesized by addition, rearrangement, substitution and halogenesis steps with phthalide and 4-pyridinecarbaldehydes as starting reagents. The intermediate and target compound I were characterized by 1H NMR, MS and HPLC. After purification by recrystallization, the compound I (98.1% purity estimated by HPLC) was exptl. used to treat colorectal cancer nude mice. The result shows that this compound obviously restrains the growth of tumors. In the experiment, the researchers used many compounds, for example, N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine (cas: 212141-54-3Safety of N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine).
N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine (cas: 212141-54-3) belongs to phthalazine derivatives. Phthalazine is isomeric with other naphthyridines including quinoxaline, cinnoline and quinazoline. Phthalazines are popular pharmacophores as they are the core chemical motifs in many commercially available drugs such as Azelastin (antihistamine), Vatalanib (vascular endothelial growth factor receptor (VEGFR) inhibitor), and Hydralazine (antihypertensive agent).Safety of N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
Referemce:
Phthalazine – Wikipedia,
Phthalazine | C8H6N2 – PubChem