253-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazine, cas is 253-52-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.
Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol. 3-(tert-Butylamino)-2-phenylpyrrolo[2,1-a]phthalazine-1-carbonitrile (4a). Reaction time 18 h. Yield 204 mg(86percent), pale-yellow crystals, mp 173?174¡ãC. IR spectrum,nu, cm?1: 3385 (NH), 3065, 2861 (CH), 2226 (CN), 1604,1486, 764, 729 (Ar). 1H NMR spectrum, delta, ppm (J, Hz):8.90 (1H, s, H-6); 8.75 (1H, d, J = 8.0, H-10); 8.05?7.25(8H, m, H Ar); 4.12 (1H, br. s, NH); 0.99 (9H, s, 3CH3).13C NMR spectrum, delta, ppm: 146.1 (=N); 134.4 (?NH);131.4 ( Ar); 129.8 ( Ar); 129.5 ( Ar); 129.1 ( Ar);128.8 ( Ar); 128.0 ( Ar); 126.1 ( Ar); 125.9 ( Ar);124.7 ( Ar); 122.5 ( Ar); 120.0 ( Ar); 116.2 ( Ar);112.7 (CN); 100.2 ( Ar); 55.4 ((CH3)3); 31.4 (CH3).Mass spectrum, m/z (Irel, percent): 340 [M]+ (17), 314 (12), 284(100), 222 (13), 206 (10), 168 (18), 129 (12), 56 (89).Found, percent: C 77.79; H 6.10; N 16.51. 22H20N4. Calculated, percent: C 77.62; H 5.92; N 16.46.
253-52-1. Other significant industrial processes that involve the use of heterogeneous catalysts include the preparation of sulfuric acid, the preparation of ammonia, the oxidation of ammonia to nitric acid, and the synthesis of methanol.253-52-1, if you are interested, you can browse my other articles.
Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem