Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 72702-95-5, C17H12BrFN2O3. A document type is Article, introducing its new discovery., 72702-95-5
Identification of quinoxalin-2(1 toggle=”yes”H)-one derivatives as a novel class of multifunctional aldose reductase inhibitors
Aim: Targeting aldose reductase and oxidative stress with quinoxalin-2(1H)-one derivatives having a 1-hydroxypyrazole head as the bioisosteric replacement of carboxylic acid. Methodology & results: Aldose reductase inhibition, selectivity and antioxidant potency of all the synthesized compounds were evaluated, and binding modes were studied by molecular docking. Most of the derivatives showed potent and selective aldose reductase inhibition, and among them 13d was the most active (IC50 = 0.107 muM), suggesting success of the bioisosteric strategy. Phenolic 3,4-dihydroxyl compound 13f showed strong antioxidant ability even comparable to that of the well-known antioxidant Trolox. Conclusion: The present study identified the excellent bioisostere of the 1-hydroxypyrazole head group along with phenolic hydroxyl and vinyl spacer in C3 side chain on constructing quinoxalinone-based multifunctional aldose reductase inhibitors.
If you¡¯re interested in learning more about 22990-19-8, below is a message from the blog Manager. 72702-95-5
Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N866 – PubChem