Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Furber, Mark and a compound is mentioned, 3260-44-4, 4-Oxo-3,4-dihydrophthalazine-1-carboxylic acid, introducing its new discovery. 3260-44-4
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H 1 antagonists. Part i
The discovery of potent small molecule dual antagonists of the human CCR3 and H1 receptors is described for the treatment of allergic diseases, for example, asthma and allergic rhinitis. Optimizing in vitro potency and metabolic stability, starting from a CCR1 lead compound, led to compound 20 with potent dual CCR3/H1 activity and in vitro metabolic stability.
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Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N672 – PubChem