Category: 119-39-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

A mixture of ethyl 3-[1-[4-(2-bromoethoxy)benzyl]-3-phenyl-1H-pyrazol-4-yl]propionate (1050 mg), 1(2H)-phthalazinone (530 mg), potassium carbonate (1000 mg) and N,N-dimethylformamide (15 ml) was stirred at 90C for 5 hours. The reaction mixture was poured into water, and extracted with ethyl acetate. The ethyl acetate layer was washed successively with dilute hydrochloric acid and saturated aqueous sodium chloride solution, dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography to obtain a colorless oily substance from the fraction eluted with ethyl acetate-hexane (1:1, volume ratio). After a mixture of the resulting colorless oily substance, 1N aqueous sodium hydroxide solution (5 ml), tetrahydrofuran (5 ml) and ethanol (5 ml) was stirred at room temperature for 3 hours, 1N hydrochloric acid (5 ml) was added to the mixture, and then the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with a saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated. The resulting colorless crystals were collected by filtration to obtain 3-[1-[4-[2-[1-oxophthalazin-2(1H)-yl]ethoxy]benzyl]-3-phenyl-1H-pyrazol-4-yl]propionic acid (1460 mg, yield : 90%). This was recrystallized from acetone-hexane. Melting point: 155-156C.

119-39-1, As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; EP1228067; (2004); B1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The phthalazine compound, name is Phthalazin-1(2H)-one,cas is 119-39-1, mainly used in chemical industry, its synthesis route is as follows.,119-39-1

General procedure: The precursor lactam (1 mmol) was dissolved in DMF-TEA 1:1(2 mL), then K2CO3 (0.410 g, 3 mmol), CuI (190 mg, 1 mmol),PdCl2(PPh3)2 (17.5 mg, 0.025 mmol) and aryl halide (1.1 mmol)were added to the solution. The reaction mixture was stirred underargon, at 110C for overnight. The reaction mixture was ltered andbrine (30 mL) was added to the solution. The precipitated solid wasltered off then washed with brine and water. The crude productwas puried by column chromatography (on silica, using DCM orDCM-MeOH 100-5:1 mixtures as eluent) and subsequent crystal-lization from MeOH, EtOH,iPrOH,tBuOH, MeOH-water or EtOH-water.

As the rapid development of chemical substances, we look forward to future research findings about 119-39-1

Reference£º
Article; Jernei, Tamas; B?sze, Szilvia; Szabo, Rita; Hudecz, Ferenc; Majrik, Katalin; Csampai, Antal; Tetrahedron; vol. 73; 43; (2017); p. 6181 – 6192;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

To a round bottom flask containing DMF (10 mL) under an atmosphere of argon was added, phthalazone (300 mg, 2.05 mmol). To solution was then cooled to 0C before sodium hydride (60% in dispersion oil, 61 mg, 2.53 mmol) was added portion wise iodomethane (119 m L, 1.92 mmol). The reaction was stirred overnight before the solvent was removed in vacuo and the crude material purified directly via flash column chromatography using -pentane: EtOAc (10:1) affording 2-2-Mcthylphthalazin- 1 (2H)-onc as a white solid (210 mg, 1.31 mmol, 64%). 3H NMR (400 MHz, CDCb) d = 8.42 – 8.38 (m, 1H), 8.12 (s, 1H), 7.81 – 7.70 (m, 2H), 7.69 – 7.65 (m, 1H), 3.83 (s, 3H); 13C NMR (100 MHz, CDCb) d = 159.7, 137.6, 133.0, 131.6, 129.8, 127.8, 126.5, 126.0, 39.5. The data is in accordance with known literature (Outerbridge, V.M., Landge, S.M., Tamaki, H. & Torok, B. Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones. Synthesis 11, 1801-1806, 2009)., 119-39-1

As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

Example 1. 2-(4-Bromobutyl)-1(2H)-phthalazinone . Small portions (2.5 g, 60 mmol) of a dispersion of 60% NaH in mineral oil were added over a solution of 1(2H)-phthalazinone (7.3 g, 50 mmol) in dimethylformamide (100 mL) cooled to 0C. The reaction mixture was left to reach room temperature and kept stirred for an hour. 1,4-dibromobutane (18 mL, 150 mmol) was then added at a time and the reaction mixture was stirred, at room temperature, for 4 hours. The reaction mixture was poured over cnished ice, extracted with ethyl ether (twice), and the organic extracts were dried over anhydrous Na2SO4and concentrated to dryness. The excess dibromobutane was eliminated by distillation and the obtained residue was purified by flash chromatography (CH2Cl2), yielding an oil (11.6 g, yield: 83%) identified on the basis of its spectroscopic data as the title product, 119-39-1

The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FABRICA ESPANOLA DE PRODUCTOS, QUIMICOS Y FARMACEUTICOS, S.A. (FAES); EP875512; (1998); A2;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

Weigh 0.324g of commercial compound C1a dissolved in 3ml DMF,60% NaH 0.16g was added under ice bath.Stir for 30 minutes and add 0.591 g of ethyl 4-(bromomethyl)benzoate.Stir for 1 hour at room temperature. Pour the reaction mixture into 100ml of crushed ice.Extract several times with ethyl acetate, combine the organic layers, and evaporate.Light yellow solid (Intermediate C1b).Dissolve this intermediate in 10 ml of THF and add 2.9 ml of 8N NaOH.Return overnight. The reaction solution was diluted with water, and the aqueous layer was washed with ethyl acetate.The aqueous layer was adjusted to pH 6 with 6N HCl, precipitated and filtered.The precipitate is washed with water and dried to give a beige product C1c, 119-39-1

119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jingkang; Xiong Bing; Zhao Lele; Li Jia; Geng Meiyu; Ma Lanping; Chen Danqi; Su Mingbo; Zhou Yubo; Hu Xiaobei; Liu Hongchun; Shen Aijun; (54 pag.)CN107879975; (2018); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO15,mainly used in chemical industry, its synthesis route is as follows.,119-39-1

EXAMPLE 7A Preparation of Hydralazine Base in the Absence of Organic Solvent A 2 L, 3-necked, round-bottomed flask fitted with a temperature probe and condenser, and was charged 375 mL of hydrazine hydrate; the solution was then cooled to 0 to 5 C. About 75 g of 1-chlorophthalazine salt was added in portions at a rate to maintain the solution temperature at 0 to 5 C. After addition, the solution was stirred at 20 to 25 C. for about 24 hrs. The reaction mixture was then cooled to 0 to 5 C. and 150 mL of methanol was added, the solution stirred for 3 hrs, and the resulting solid material was filtered, washed with 150 mL of cold methanol, and dried under vacuum at 35 C. Yield 99%.

With the synthetic route has been constantly updated, we look forward to future research findings about Phthalazin-1(2H)-one,belong phthalazine compound

Reference£º
Patent; Navinta LLC; US2007/129546; (2007); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. Novel Preparation of 1-Chlorophthalazine. One mole equivalent (250 g) of 1(2H)-phthalazinone and 3.8 mole equivalents (775 g) of phosphorus oxychloride were charged into a 3-L, 3-necked flask fitted with a temperature probe and condenser. The slurry was stirred and heated to 80 C., maintained at that temperature for 30 minutes, and then the heat source was removed. Thin layer chromatographic analysis indicated that conversion to 1-chlorophthalazine was complete. The mixture was allowed to cool to room temperature, and 1.6 L of hexanes was added. The resulting slurry was stirred for several minutes, and the hexane layer was decanted. Addition of hexanes and decantation was repeated two more times. Then 1.6 L of tetrahydrofuran was added; as the solution was stirred, an off-white precipitate formed. The solid was isolated by filtration and washed with 250 mL of cold tetrahydrofuran to afford an 85-100% yield of 1-chlorophthalazin, the desired product, as an off-white powder that could be dried and characterized., 119-39-1

As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Patent; Nelson, Deanna J.; US2005/137397; (2005); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the solution of sodium methoxide (0,0165 mol of Na) in dry methanol (70 ml) was added 2H-phthalazin-l-on (0,0153 mol). The mixture was stirred and refluxed for 30 minutes, then cooled to ambient temperature and bis-tosyl-derivative of 2- methylaminoethanol (0.0230 mol) was added. Afterwards the reaction mixture was heated and refluxed for 10 hours. After cooling to room temperature the product was filtrated and recrystalized. If the product was well soluble in reaction solvent, the solvent was first evaporated and to the residue water (20ml) was added. The aqueous layer was extracted with chloroform (3x20ml). The combined extracts were dried over anhydrous MgSO4 and vacuum concentrated till dryness. The residue was purified by column chromatography (silica gel).4,N-Dimethyl-N-[2-(l-oxo-lH-phthalazin-2-yl)-ethyl]-benzenesulfonamide (compound no 5) 3.51 (t, 2H, CH2, J=6.3), 2.90 (s, 3H, N-Me), 2.34 (s, 3H5 Tos-Me);13C NMR (CDCl3) delta: 159.3 (C=O), 143.0, 137.8, 134.9, 133.7, 133.0, 131.5, 129.5,129.4, 127.0, 126.5, 125.9, 48.4 (N(C=O)-CH2), 48.1 (N(Me-CH2), 35.0 (N-Me), 21.4(Tos-Me)Elemental Analysis:Calculated for C18H19N3O3S M = 357. 43 g/mol:C 60.49, H 5.36, N 11.76, S 8,97;Found: C 60.39; H 5.42, N 11.63, S 9.08.

119-39-1, 119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Patent; UNIWERSYTET LODSKI; WO2009/51504; (2009); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belong phthalazine compound,Phthalazin-1(2H)-one,119-39-1,Molecular formula: C8H6N2O,mainly used in chemical industry, its synthesis route is as follows.,119-39-1

Weigh 0.324g of commercial compound C1a dissolved in 3ml DMF,60% NaH 0.16g was added under ice bath.Stir for 30 minutes and add 0.591 g of ethyl 4-(bromomethyl)benzoate.Stir for 1 hour at room temperature. Pour the reaction mixture into 100ml of crushed ice.Extract several times with ethyl acetate, combine the organic layers, and evaporate.Light yellow solid (Intermediate C1b).Dissolve this intermediate in 10 ml of THF and add 2.9 ml of 8N NaOH.Return overnight. The reaction solution was diluted with water, and the aqueous layer was washed with ethyl acetate.The aqueous layer was adjusted to pH 6 with 6N HCl, precipitated and filtered.The precipitate is washed with water and dried to give a beige product C1c

With the synthetic route has been constantly updated, we look forward to future research findings about Phthalazin-1(2H)-one,belong phthalazine compound

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jingkang; Xiong Bing; Zhao Lele; Li Jia; Geng Meiyu; Ma Lanping; Chen Danqi; Su Mingbo; Zhou Yubo; Hu Xiaobei; Liu Hongchun; Shen Aijun; (54 pag.)CN107879975; (2018); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The phthalazine compound, cas is 119-39-1 name is Phthalazin-1(2H)-one, mainly used in chemical industry, its synthesis route is as follows.,119-39-1

General procedure: The Mitsunobu reaction was carried out under argon. To a stirred solution of TPP (0,0102 mol) in dry THF (10 ml) was slowly added DEAD (0,0102 mol, solution in toluene c ? 40%) at -10C. Then a solution of phthalazinone 1 (0.0068 mol) in THF (44 ml) was added dropwise. The whole lot was mixed for 15 min at -10C and next was added the appropriate derivative of N-methylethanolamine 7 or 8 (0.00748 mol) in THF (5 ml) at -10C. The mixture was stirred during 2 hrs at -10C, after which time, the reaction mixture was warmed to ambient temperature and stirred in this conditions for 20 hrs. All volatile materials were removed under reduced pressure, ethyl ether (20ml) was added to the residue and the whole lot was stirred for 0.5 hrs at ambient temperature. The separate white solid was collected by flirtation, washed with ether and filtrate was evaporated to dryness. The residue was subjected to column chromatography to give the pure product 11.

As the rapid development of chemical substances, we look forward to future research findings about 119-39-1

Reference£º
Article; Malinowski, Zbigniew; Szczes?niak, Aleksandra K.; Pakulska, Wanda; Sroczy?ski, Dariusz; Czarnecka, Elzbieta; Epsztajn, Jan; Synthetic Communications; vol. 44; 24; (2014); p. 3572 – 3581;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem