Category: 119-39-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

Weigh 2H-phthalazin-1-one (150 mmol),(3,4-Dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester-5-yl)-aminoO-chlorobenzyl formate (195 mmol) in a reaction flask,Add DMF100ml,The reaction was carried out at 55 C overnight.Stop the reaction,Add 100ml of water,200ml of dichloromethane,extraction,Separating the organic phase,The aqueous phase was further extracted with dichloromethane (3*50 ml).Combine the organic phase,Dry over anhydrous sodium sulfate,Purification by column chromatography gave the title compound., 119-39-1

The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (19 pag.)CN109180642; (2019); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Phthalazin-1(2H)-one, cas is 119-39-1, it is a common heterocyclic compound, the phthalazine compound, its synthesis route is as follows.,119-39-1

To phthalazinone9(0.205 g, 1.40 mmol) in DMF (2 mL) was added NaH (60% dispersion in mineral oil) (0.084 g, 2.10 mmol) and the resulting solution stirred for 30 min at room temperature. Nitroimidazole19(0.27 g, 1.54 mmol) was added and the solution was stirred for 30 min, then quenched on ice. The resulting suspension was filtered, the collected solid washed with water (5 mL), X4 (5 mL) and dried in vacuo to yield10(0.04 g, 10%) as a yellow solid, mp 207-209 C. deltaH((CD3)2SO) 8.49 (1H, s, H-4), 8.29 (1H, dd,J= 7.84, 0.7 Hz, H-8), 7.98 (2H, d,J= 3.7 Hz, H-7, H-6), 7.93-7.87 (1H, m, H-5), 7.19 (1H, s, H-4?), 5.47 (2H, s, CH2), 4.00 (3H, s, CH3). deltaC((CD3)2SO) 158.4 (C = O), 145.6 (C), 138.9 (C), 134.1 (C), 133.9 (C), 132.4 (CH), 129.3 (C), 128.4 (CH), 127.1 (CH), 127.9 (C), 125.9 (CH), 43.6 (CH2), 34.4(CH3). HRMS calcd for C13H12N5O3(M + H)m/z286.0935, found 286.0941. LRMSm/z286.1 (100%, M + H). HPLC purity: 94.4% (effector10: 0.1%).

As the rapid development of chemical substances, we look forward to future research findings about 119-39-1

Reference£º
Article; Dickson, Benjamin D.; Wong, Way Wua; Wilson, William R.; Hay, Michael P.; Molecules; vol. 24; 8; (2019);,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a round bottom flask containing THF (10 mL) under an atmosphere of argon was added, phthalazone (480 mg, 3.28 mmol). To solution was then cooled to 0C before sodium hydride (60% in dispersion oil, 97 mg, 4.04 mmol) was added portion wise. The reaction was then stirred for 30 minutes at 0C before warming to room temperature after which 2- (trimethylsilyl)ethoxymethyl chloride (0.70 mL, 3.97 mmol mmol) was added dropwise. The reaction mixture was left to stir overnight after which the solvent was removed in vacuo. The crude mixture was then extracted with DCM (3 x 10 mL) and washed with brine (3 x 10 mL). The organic layer was collected, dried with magnesium sulfate and the excess solvent removed in vacuo. The crude material was then purified by flash column chromatography (2:3 n-Pent:EtOAc) to afford 2-((2-trimethylsilyl)ethoxyl)methyl) phthalazin-1 (2//)-one as a colourless oil (435 mg, 1.57 mmol, 46%). *H NMR (400 MHz, CDCb) d = 8.41 (d, J = 7.8 Hz, 1H), 8.15 (s, 1H), 7.76 (dt, J = 21.7, 7.6 Hz, 2H), 7.67 (d, / = 7.7 Hz, 1H), 5.55 (s, 2H), 3.74 – 3.68 (m, 2H), 0.99 – 0.92 (m, 2H), – 0.05 (s, 9H); 13C NMR (100 MHz, CDCb) d = 161.4, 139.6, 134.9, 133.2, 131.2, 129.4, 128.4, 127.6, 80.4, 68.5, 19.5, 0.00 (3C); IR (v, cm4): 1661, 1081, 833, 758; HRMS (ESI) for Ci4H2oN223Na0228Si [M+Na]+ requires 299.1186 found 299.1185., 119-39-1

As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(2H)-pyridazinone 1.00 g (6.84 mmol) and triphenylphosphine 1.79 g (6.84 mmol) were added to 25 ml of tetrahydrofuran, and 0.85 g (6.84 mmol) of 2-bromoethanol was added dropwise in an ice bath.After the dropwise addition was completed, 1.22 g (7.00 mmol) of diethyl azodicarboxylate was added dropwise to the ice bath.After stirring for 1 hour in an ice bath, the reaction was carried out at room temperature until TLC followed the progress of the reaction.The solvent was evaporated under reduced pressure. EtOAc EtOAc m.The product was obtained as a reddish brown solid, 1.01 g, yield 58%., 119-39-1

As the paragraph descriping shows that 119-39-1 is playing an increasingly important role.

Reference£º
Patent; East China University of Science and Technology; Xu Xiaoyong; Li Zhong; Chen Xiulei; Li Wei; Jia Haowu; Cao Xiaofeng; Shao Xusheng; Xu Zhiping; (70 pag.)CN108276352; (2018); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

To a round bottom flask containing THF (10 mL) under an atmosphere of nitrogen was added, phthalazone (500 mg, 3.41 mmol), di-/c/ -butyl dicarbonate (1.11 g, 5.12 mmol) and DMAP (620 mg, 5.12 mmol). The reaction was stirred overnight at room temperature before the solvent was removed in vacuo and the crude material purified directly via flash column chromatography using -pentane: EtOAc (5: 1) tert- Butyl 1 -oxophthalazine-2( i H)- carboxylate as a white solid (765 mg, 3.11 mmol, 91%). 3H NMR (400 MHz, CDCb) d = 8.43 (dd, 7 = 7.9, 1.3 Hz, 1H), 7.83 (td, 7 = 7.5, 1.4 Hz, 1H), 7.77 (td, 7 = 7.6, 1.3 Hz, 1H), 7.68 (dd, 7 = 7.5, 1.3 Hz, 1H), 1.66 (s, 9H);13C NMR (100 MHz, CDCb) d = 158.3, 150.9, 138.9, 134.2, 132.3, 129.2, 128.7, 127.5, 126.4, 85.9, 27.8 (3C); IR (v, cm4): 2980, 1720, 1641, 1470, 1325, 1130; HRMS (ESI) for C13H14N2O3 (0556) [M+H]+ requires 247.1012 found 247.1015; Mp: 81 – 83C

119-39-1, The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: The reaction was carried out under argon. To a stirred suspension of sodium hydride (4.25 mol) in dry DMF (10 cm3) was added slowly a solution of 2H-phthalazin-1-one 2 (3.95¡Á10-3 mol) in dry DMF (50 cm3). The reaction mixture was stirred at room temperature for 45 minutes. Next, the whole lot was cooled to 0 C and the solution of N-(2-bromoethyl)phthalimide (5.92¡Á10-3 mol) in dry DMF (10 cm3) was added in portions. At first the mixture was kept for 5 hours in 0 C and later for 16 hours in ambient temperature. After this time the reaction mixture was poured into ice-water mixture (100 cm3) and next extracted with CHCl3 (3¡Á50 cm3). The combined extracts were dried over MgSO4 and concentrated under vacuum. The isoindole-1,3-dione 3 was isolated by column chromatography or crystallization.

119-39-1, 119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Article; Malinowski, Zbigniew; Sroczy?ski, Dariusz; Szczes?niak, Aleksandra K.; Synthetic Communications; vol. 45; 15; (2015); p. 1743 – 1750;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, Phthalazin-1(2H)-one is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

261.3 mg of acetic anhydride copper (II) and Molecular Sieve 4A (79.1 mg) were added to 80.7 mg of the resin obtained in Process 4. 400.0 mg of 1(2H)-phthalazinone and 984 mul of diisopropylethylamine in a solution of NMP (4 ml) were further added therein and stirred at 50C for 23 hours. After removing the reaction solution, the resin was washed with DMF, water, ethanol and DCM three times each and dried under reduced pressure.

119-39-1, The synthetic route of 119-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ajinomoto Co., Inc.; EP1454898; (2004); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-39-1,Phthalazin-1(2H)-one,as a common compound, the synthetic route is as follows.

A solution of 2H-Phthalazin-l-one (1.01 g, 5 mmol) in phosphorus oxychloride (5 mL) was stirred at 130 0C for 1.5 h. The phosphorus oxychloride was removed under reduced pressure. The residue was partitioned between water (10 mL) and methylene chloride (50 mL). The methylene chloride phase was separated, dried over MgSO4, and evaporated to give a yellow solid (1.015 g, 90%).[00139] The above crude product (83 mg, 0.50 mmol), N-methyl-4-methoxy-aniline (69 mg, 0.50 mmol) and cesium carbonate (200 mg, 0.61 mmol) were stirred in anhydrous DMF (1 mL) in a sealed tube at rt for 17 h. The reaction was diluted with water (5 mL) and extracted with EtOAc (2×20 mL). The EtOAc solution was washed with water (5 mL), dried, and evaporated to give a brown residue. The crude product was purified by column chromatography (SiO2, EtO Ac:hexanes/15-50%) to give a light yellow solid (5 mg, 4%): 1H NMR (CDCl3) 9.11 (s, IH), 7.85 (m, IH), 7.66 (m, IH), 7.48-7.47 (m, 2H), 7.40-7.10 (m, 2H)5 6.87-6.81 (m, IH), 3.80 (s, 3H), 3.63 (s, 3H)., 119-39-1

119-39-1 Phthalazin-1(2H)-one 8394, aphthalazine compound, is more and more widely used in various fields.

Reference£º
Patent; MYRIAD GENETICS, INC.; CYTOVIA, INC.; WO2006/74223; (2006); A2;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The phthalazine compound, cas is 119-39-1 name is Phthalazin-1(2H)-one, mainly used in chemical industry, its synthesis route is as follows.,119-39-1

[0322] General procedure: To a mixture ofphthalazone in anhydrous DMF (270mL), NaOEt (21% w/w solution in EtOH, 51 mL, 137 mmol) was added. After 15 min,propargyl bromide (80% solution in toluene, 14.8 mL, 20.4 g, 137 mmol) was added and thereaction mixture was stirred at r.t. for 2 days. After evaporation, the residue was stirred withhot H20 (3 L), cooled down and the product was filtered (51%).

As the rapid development of chemical substances, we look forward to future research findings about 119-39-1

Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FOKIN, Valery; SHARPLESS, Barray, K.; ECKMANN, Lars; MIYAMOTO, Yukiko; WO2014/205414; (2014); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Phthalazin-1(2H)-one, cas is 119-39-1, it is a common heterocyclic compound, the phthalazine compound, its synthesis route is as follows.,119-39-1

A. Novel Preparation of 1-Chlorophthalazine. One mole equivalent (250 g) of 1(2H)-phthalazinone and 3.8 mole equivalents (775 g) of phosphorus oxychloride were charged into a 3-L, 3-necked flask fitted with a temperature probe and condenser. The slurry was stirred and heated to 80 C., maintained at that temperature for 30 minutes, and then the heat source was removed. Thin layer chromatographic analysis indicated that conversion to 1-chlorophthalazine was complete. The mixture was allowed to cool to room temperature, and 1.6 L of hexanes was added. The resulting slurry was stirred for several minutes, and the hexane layer was decanted. Addition of hexanes and decantation was repeated two more times. Then 1.6 L of tetrahydrofuran was added; as the solution was stirred, an off-white precipitate formed. The solid was isolated by filtration and washed with 250 mL of cold tetrahydrofuran to afford an 85-100% yield of 1-chlorophthalazin, the desired product, as an off-white powder that could be dried and characterized.

As the rapid development of chemical substances, we look forward to future research findings about 119-39-1

Reference£º
Patent; Nelson, Deanna J.; US2005/137397; (2005); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem