Category: 119-39-1

We know that the rate of many reactions can be accelerated by catalysts. A catalyst speeds up the rate of a reaction by lowering the activation energy; in addition, the catalyst is regenerated in the process. Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound, below Introduce a new synthetic route., 119-39-1

To the solution of sodium methoxide (0,0165 mol of Na) in dry methanol (70 ml) was added 2H-phthalazin-l-on (0,0153 mol). The mixture was stirred and refluxed for 30 minutes, then cooled to ambient temperature and bis-tosyl-derivative of 2- methylaminoethanol (0.0230 mol) was added. Afterwards the reaction mixture was heated and refluxed for 10 hours. After cooling to room temperature the product was filtrated and recrystalized. If the product was well soluble in reaction solvent, the solvent was first evaporated and to the residue water (20ml) was added. The aqueous layer was extracted with chloroform (3x20ml). The combined extracts were dried over anhydrous MgSO4 and vacuum concentrated till dryness. The residue was purified by column chromatography (silica gel).4,N-Dimethyl-N-[2-(l-oxo-lH-phthalazin-2-yl)-ethyl]-benzenesulfonamide (compound no 5) 3.51 (t, 2H, CH2, J=6.3), 2.90 (s, 3H, N-Me), 2.34 (s, 3H5 Tos-Me);13C NMR (CDCl3) delta: 159.3 (C=O), 143.0, 137.8, 134.9, 133.7, 133.0, 131.5, 129.5,129.4, 127.0, 126.5, 125.9, 48.4 (N(C=O)-CH2), 48.1 (N(Me-CH2), 35.0 (N-Me), 21.4(Tos-Me)Elemental Analysis:Calculated for C18H19N3O3S M = 357. 43 g/mol:C 60.49, H 5.36, N 11.76, S 8,97;Found: C 60.39; H 5.42, N 11.63, S 9.08.

In every case, we must determine the overall rate law from experimental data and deduce the mechanism from the rate law (and sometimes from other data). you can also browse my other articles about 119-39-1, if you are interested., 119-39-1

Reference£º
Patent; UNIWERSYTET LODSKI; WO2009/51504; (2009); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound. A new synthetic method of this compound is introduced below. 119-39-1

Stage A 2-{2-[(Tetrahydro-2-pyranyl)oxy]ethyl}-1-oxophthalazine A solution of 41.5 g of potassium hydroxide in 53 ml of water is added at room temperature to a solution of 61 g of 1-oxophthalazine in 430 ml of dimethyl sulfoxide. After 30 minutes, 130 g of tetrahydro-2-pyranyl 2-bromoethyl ether are added to the suspension obtained. The mixture is left stirring for 30 hours at room temperature and then concentrated, the residue is taken up in 400 ml of water and the product is extracted with dichloromethane. The organic phase is concentrated. Yield: 80% Proton nuclear magnetic resonance spectrum (400 MHz, solvent CDCl3): 1.3 to 2 ppm,m,6H; 3.3 to 4.8 ppm,m+m, 1H+6H; 7.6 to 7.9 ppm,m,3H; 8.15 ppm,s,1H; 8.4 ppm,m,1H

119-39-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,119-39-1 ,Phthalazin-1(2H)-one, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Adir et Compagnie; US5077288; (1991); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 1 (COMPARATIVE) Preparation of 1-Chlorophthalazine According to the process disclosed in U.S. Pat. Pub. 20050137397, the disclosure of which is incorporated herein by reference, one mole equivalent (250 g) of 1(2H)-phthalazinone and 3.8 mole equivalents (775 g) of phosphorus oxychloride were charged into a 3-L, 3-necked flask fitted with a temperature probe and condenser. The slurry was stirred and heated to 80 C., maintained at that temperature for 30 minutes, and then the heat source was removed. The mixture was allowed to cool to room temperature and 1.6 L of hexane were added. The resulting slurry was stirred for about 30 minutes, allowed to settle, and the hexane layer was decanted; the addition of hexane and decantation was repeated three times. Then 1.6 L of tetrahydrofuran was added to the slurry and a yellow precipitate formed. The yellow solid (reported in the ‘397 application as an off white solid) was isolated by filtration and then washed with 250 mL of cold tetrahydrofuran to afford a 50% yield (reported yield in the ‘397 application is 85 to 100%) of 1-chlorophthalazine.

119-39-1. Other significant industrial processes that involve the use of heterogeneous catalysts include the preparation of sulfuric acid, the preparation of ammonia, the oxidation of ammonia to nitric acid, and the synthesis of methanol.119-39-1, if you are interested, you can browse my other articles.

Reference£º
Patent; Navinta LLC; US2007/129546; (2007); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

One of the major reasons is to use measurements of the macroscopic properties of a system, 119-39-1, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound, introduce a new downstream synthesis route.

Weighing 2H-phthalazin-1-one (150 mmol), tert-butyl 5-({[(2-chlorophenyl)methoxy]carbonyl}amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate (195 mmol) in reaction bottle, adding DMF100ml, 55 C lower reaction overnight, stopping the reaction, by adding water 100 ml, dichloromethane 200 ml, extraction, separation of the organic phase, the aqueous phase to continue to dichloromethane is used for extraction (3 * 50 ml), the combined organic phase, anhydrous sodium sulfate drying, column chromatography purification obtained title compound.

119-39-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,119-39-1 ,Phthalazin-1(2H)-one, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (11 pag.)CN109481444; (2019); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound. A new synthetic method of this compound is introduced below. 119-39-1

A mixture of the commercially available phthalazin-l(2//)-one (5.0 g, 34.0 mmol) and phosphorus oxychloride (POCh) (25 mL) was heated with stirring at l00C for 2 h. After cooling to room temperature, the excess POCI3 was completely distilled out under reduced pressure. The residue was triturated with toluene (2 x 25 mL) and followed with THF (100 mL), and the solid product was collected by filtration and washed with THF. The product was then dissolved in DCM, washed with saturated aqueous NaHC03 solution, dried over sodium sulfate and evaporated under reduced pressure to give 1- chlorophthalazine. Yield 4.6 g (82%); mp 119-121 C (lit.33 mp 132-134 C). (0220) [0134] NMR (DMSO-^e) d 8.20 (2H, t, J = 7.2 Hz, ArH), 8.33 (2H, t, J = 7.6 Hz, ArH), 9.73 (1H, s, ArH). (0221) [0135] 13C NMR (DMSO-?) d 126.1, 128.4, 128.7, 155.3. HRMS [ESL]: calculated for C8H5ClN2, 165.0220 [M+H]+, found 165.0212.

119-39-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,119-39-1 ,Phthalazin-1(2H)-one, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; ACADEMIA SINICA; SU, Tsann-long; LEE, Te-chang; CHEN, Tai-lin; (92 pag.)WO2019/99755; (2019); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound. An updated downstream synthesis route of 119-39-1 as follows. 119-39-1

General procedure: The Mitsunobu reaction was carried out under argon. To a stirred solution of TPP (0,0102 mol) in dry THF (10 ml) was slowly added DEAD (0,0102 mol, solution in toluene c ? 40%) at -10C. Then a solution of phthalazinone 1 (0.0068 mol) in THF (44 ml) was added dropwise. The whole lot was mixed for 15 min at -10C and next was added the appropriate derivative of N-methylethanolamine 7 or 8 (0.00748 mol) in THF (5 ml) at -10C. The mixture was stirred during 2 hrs at -10C, after which time, the reaction mixture was warmed to ambient temperature and stirred in this conditions for 20 hrs. All volatile materials were removed under reduced pressure, ethyl ether (20ml) was added to the residue and the whole lot was stirred for 0.5 hrs at ambient temperature. The separate white solid was collected by flirtation, washed with ether and filtrate was evaporated to dryness. The residue was subjected to column chromatography to give the pure product 11.

119-39-1, A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 119-39-1, you can also browse my other articles.

Reference£º
Article; Malinowski, Zbigniew; Szczes?niak, Aleksandra K.; Pakulska, Wanda; Sroczy?ski, Dariusz; Czarnecka, Elzbieta; Epsztajn, Jan; Synthetic Communications; vol. 44; 24; (2014); p. 3572 – 3581;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

119-39-1, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound. Here is a downstream synthesis route of the compound 119-39-1

General procedure: To a solution of sodium methoxide (0.0165 mol) in dry MeOH (70 ml) was added 2H-phthalazin-1-one 1 (0.0153 mol). The mixture was heated to boiling for 30 minutes. Afterwards, toluene-4-sulfonic acid 2-[methyl-(toluene-4-sulfonyl)-amino]-ethyl ester (6) (0.0230 mol) was added and heating was continued for next 7 hrs. After this time, the mixture was cooled to ambient temperature. The separated product was filtrated off, washed with dry methanol and purified by crystallization or column chromatography.

119-39-1, There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 119-39-1

Reference£º
Article; Malinowski, Zbigniew; Szczes?niak, Aleksandra K.; Pakulska, Wanda; Sroczy?ski, Dariusz; Czarnecka, Elzbieta; Epsztajn, Jan; Synthetic Communications; vol. 44; 24; (2014); p. 3572 – 3581;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

A heterogeneous catalyst is a catalyst that is present in a different phase than the reactants. Such catalysts generally function by furnishing an active surface upon which a reaction can occur. 119-39-1, name is Phthalazin-1(2H)-one, introduce a new downstream synthesis route as follows. 119-39-1

A mixture of ethyl 3-[1-[4-(2-bromoethoxy)benzyl]-3-phenyl-1H-pyrazol-4-yl]propionate (1050 mg), 1(2H)-phthalazinone (530 mg), potassium carbonate (1000 mg) and N,N-dimethylformamide (15 ml) was stirred at 90C for 5 hours. The reaction mixture was poured into water, and extracted with ethyl acetate. The ethyl acetate layer was washed successively with dilute hydrochloric acid and saturated aqueous sodium chloride solution, dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography to obtain a colorless oily substance from the fraction eluted with ethyl acetate-hexane (1:1, volume ratio). After a mixture of the resulting colorless oily substance, 1N aqueous sodium hydroxide solution (5 ml), tetrahydrofuran (5 ml) and ethanol (5 ml) was stirred at room temperature for 3 hours, 1N hydrochloric acid (5 ml) was added to the mixture, and then the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with a saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated. The resulting colorless crystals were collected by filtration to obtain 3-[1-[4-[2-[1-oxophthalazin-2(1H)-yl]ethoxy]benzyl]-3-phenyl-1H-pyrazol-4-yl]propionic acid (1460 mg, yield : 90%). This was recrystallized from acetone-hexane. Melting point: 155-156C.

Other significant industrial processes that involve the use of heterogeneous catalysts include the preparation of sulfuric acid, the preparation of ammonia, the oxidation of ammonia to nitric acid, and the synthesis of methanol.119-39-1, if you are interested, you can browse my other articles.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; EP1228067; (2004); B1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound. A new synthetic method of this compound is introduced below. 119-39-1

To a solution of sodium methoxide (1.52¡Á10-2 mol) in dry MeOH (40 cm3) was added 2H-phthalazin-1-one 2 (0.0137 mol). The mixture was heated under reflux for 30 minutes. Afterwards, N-tosylaziridine (1.64¡Á10-2 mol) was added and heating was continued for next 10 h. Then the mixture was cooled to ambient temperature and neutralized by solution of hydrochloric acid (1:1). The separated product was filtrated, washed with dry MeOH and purified by recrystallization from AcOEt.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Phthalazin-1(2H)-one, 119-39-1

Reference£º
Article; Malinowski, Zbigniew; Sroczy?ski, Dariusz; Szczes?niak, Aleksandra K.; Synthetic Communications; vol. 45; 15; (2015); p. 1743 – 1750;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

One of the major reasons is to use measurements of the macroscopic properties of a system, 119-39-1, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.Phthalazin-1(2H)-one, cas is 119-39-1,the phthalazine compound, introduce a new downstream synthesis route.

Weighing 2H-phthalazin-1-one (150 mmol), tert-butyl 5-{[(2-chlorophenoxy)carbonyl]amino}-3,4-dihydroisoquinoline-2(1H)-carboxylate (195 mmol) in reaction bottle, adding DMF100ml, 55 C lower reaction overnight, stopping the reaction, by adding water 100 ml, dichloromethane 200 ml, extraction, separation of the organic phase, the aqueous phase to continue to dichloromethane is used for extraction (3 * 50 ml), the combined organic phase, anhydrous sodium sulfate drying, column chromatography purification obtained title compound.

The chemical industry reduces the impact on the environment during synthesis,119-39-1,Phthalazin-1(2H)-one,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; Nanjing Advanced Biological Materials And Process Equipment Institute Co., Ltd.; Guo Chengjie; (12 pag.)CN109481442; (2019); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem