Category: 122-99-6

Electric Literature of 122-99-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 122-99-6, Name is 2-Phenoxyethanol, SMILES is OCCOC1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Soliman, Saied M., introduce new discover of the category.

A novel route for the synthesis of Cu(II)-triazolophthalazine complexes using the Cu(II)-promoted cyclization dehydrogenation reactions of hydrazonophthalazines under reflux was presented. Two hydrazonophthalazines were cyclized to the corresponding triazolophthalazine ligands, 3-pyridin-2-yl-3,10b-dihydro-[1,2,4]triazolo[3,4-a]phthalazine (TPP) and 3-(3,10b-dihydro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-benzoic acid (TP3COOH), followed by in situ complexation with Cu(II) yielding six novel Cu(II)-triazolophthalazine complexes depending on the reaction conditions. The molecular and supramolecular structures of the Cu(II)-triazolophthalazine complexes were discussed. The metal sites have rectangular pyramidal geometry in the [Cu(TPP)Cl-2](2); 1 and [Cu(TP3COOEt)Cl-2(H2O)](2); 4 dinuclear complexes, distorted square planar in [Cu(TP3COOMe)(2)Cl-2]; 3, [Cu(TP3COOH)(2)Cl-2]; 5 and [Cu(TP3COOH)(2)Cl-2]center dot H2O; 6 and a distorted octahedral in [Cu(TPP)(H2O)(2)(NO3)(2)]; 2. Hirshfeld analysis showed that the O horizontal ellipsis H, C horizontal ellipsis H, Cl horizontal ellipsis H (except TP3COOH and 2), N horizontal ellipsis H and pi-pi stacking interactions are the most important intermolecular contacts. The pi-pi stacking interactions are the maximum for TP3COOH and complex 6 with net C horizontal ellipsis C/C horizontal ellipsis N contacts of 19.4% and 15.4%, respectively. The orbital-orbital interaction energies of the Cu-N/Cu-Cl bonds correlated inversely with the corresponding Cu-N/Cu-Cl distances, respectively. The charge transfer processes between Cu(II) and ligand groups were also discussed. The charge densities of the Cu(II) centers are reduced to 0.663-0.995 e due to the interactions with the ligand groups coordinating it.

Electric Literature of 122-99-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 122-99-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 122-99-6, Name is 2-Phenoxyethanol, molecular formula is , belongs to phthalazine compound. In a document, author is Reddy, K. R. Vijayapal, Application In Synthesis of 2-Phenoxyethanol.

An alternative route has been developed for the synthesis of 2H indazolo[2,1-b]pthalazine-trione derivativesby one pot three component condensation reaction of benzaldehydes (1a-n)pthalhydrazide(2) and 5,5 dimethyl -1,3-cyclohexanedione (3) along with acetonitrile and DMF solvent systemusing polyaniline sulfate salt (PASS) as a catalystin good to excellent yields.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 122-99-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 122-99-6, Name is 2-Phenoxyethanol, SMILES is OCCOC1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Yan, Xiaohui, introduce new discover of the category.

Solid-phase microextraction (SPME) coupled with thermal desorption-gas chromatography (TD-GC) has become a powerful analysis tool for volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) in water samples. However, water adsorption into polar microextraction phase is usually unavoidable during the extraction process, and the burst of large amounts of water vapour during thermal desorption will cause serious problems to GC separation and detectors. Pawliszyn’s group had demonstrated that the tens of micron-thick, defect-free polydimethylsiloxane (PDMS) coating could act as a perfect barrier for water adsorption and offer much better compatibility in complex matrices. However, the PDMS overcoat largely decreased the uptake rate of polar analytes into the inner sorbent. In order to quantify the effect of PDMS coating thickness on water adsorption amount and the extraction kinetics, ultrathin PDMS layer was used to coat the polar extraction phase with polyimide (PI) as a model in this work. It was surprising to find that the PDMS coating with the thickness less than one micron can decrease the water adsorption by 96%, while the extraction efficiency for polar analytes (phenolic compounds and nitroaromatic explosives) was decreased by less than 20% at the extraction time of 30 min. Moreover, the kinetic data showed that the thinner the PDMS coating was, the less the uptake rate of polar analytes into PI extraction phase decreased. Finally, polar poly (phthalazine ether sulfone ketone) (PPESK) extraction phase was also coated with ultrathin PDMS coating to verify the universality of the strategy. Generally, the water adsorption problem in polar SPME was overcome to a great extent, and the extraction efficiency of polar analytes was mainly preserved with this ultrathin PDMS coating, which could broaden the application of SPME in the environmental field. (C) 2018 Elsevier B.V. All rights reserved.

Reference of 122-99-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 122-99-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 122-99-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 122-99-6, Name is 2-Phenoxyethanol, SMILES is OCCOC1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Ferreira, P., introduce new discover of the category.

Human aldehyde oxidase (hAOX1) is a molybdenum dependent enzyme that plays an important role in the metabolism of various compounds either endogenous or xenobiotics. Due to its promiscuity, hAOX1 plays a major role in the pharmacokinetics of many drugs and therefore has gathered a lot of attention from the scientific community and, particularly, from the pharmaceutical industry. In this work, homology modelling, molecular docking and molecular dynamics simulations were used to study the structure of the monomer and dimer of human AOX. The results with the monomer of hAOX1 allowed to shed some light on the role played by thioridazine and two malonate ions that are co-crystalized in the recent X-ray structure of hAOX1. The results show that these molecules endorse several conformational rearrangements in the binding pocket of the enzyme and these changes have an impact in the active site topology as well as in the stability of the substrate (phthalazine). The results show that the presence of both molecules open two gates located at the entrance of the binding pocket, from which results the flooding of the active site. They also endorse several modifications in the shape of the binding pocket (namely the position of Lys893) that, together with the presence of the solvent molecules, favour the release of the substrate to the solvent. Further insights were also obtained with the assembled homodimer of hAOX1. The allosteric inhibitor (THI) binds closely to the region where the dimerization of both monomers occur. These findings suggest that THI can interfere with protein dimerization.

Electric Literature of 122-99-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 122-99-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 122-99-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 122-99-6, Name is 2-Phenoxyethanol, SMILES is OCCOC1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Rafeeq, Md, introduce new discover of the category.

2-Hydrazinoquinazolin-3H-4-ones la,b were reacts with each of the anhydrides, phthalic anhydride 2a, succinic anhydride 2b and maleic anhydride 2c independently in PEG-600 at RT to yield 2-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazineecarbonyl)benzoic acid 3a,b, 4-oxo-4-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazinyl)butanoic acid 3c,d and 4-oxo-4-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazinyl)but-2-enoic acid 3e,f, respectively. 3a,b, 3c,d, 3e,f have been transformed into 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydrophthalazine-1,4-dione 4a,b, 1-(4-oxo-3,4-dihydroquinazolin-2-yl)piperazine-3,6-dione 4c,d and 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-1,2-dihydropyridazine-3,6-dione 4e,f, respectively by heating each in PEG-600 at 100 degrees C for 3-3.5 hr in high yields and in high purity, involving a dehydrative ring closure. The final compounds 4a-f have also been prepared alternatively by reacting 1 with 2 in PEG-600 at 100 degrees C for 3.5-4 hr.

Application of 122-99-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 122-99-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Patil, Smita, once mentioned the application of 122-99-6, Application In Synthesis of 2-Phenoxyethanol, Name is 2-Phenoxyethanol, molecular formula is C8H10O2, molecular weight is 138.16, MDL number is MFCD00002857, category is phthalazine. Now introduce a scientific discovery about this category.

A novel phthalazine based highly selective chromogenic and fluorogenic chemosensor for Co2+ in semi-aqueous medium: application in cancer cell imaging

A new phthalazine based chemosensor 3 was developed for the highly selective and sensitive detection of Co2+ in the mixed solvent system, CH3CN- H2O ( 1 : 1, v/ v). In the presence of Co2+, the colour of the solution 3 changed from yellow to green; the absorption maxima of 3 was red- shifted from 383 nm to 435 nm, and the fluorescence of 3 at 550 nm was significantly enhanced. The sensor 3 showed a detection limit down to 25 nM by forming a complex species with Co2+ in 1 : 1 stoichiometry. Furthermore, by means of confocal laser scanning microscopy experiments, it has demonstrated that it can be used as a fluorescent probe for monitoring Co2+ in living cells.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 122-99-6, Name is 2-Phenoxyethanol, molecular formula is C8H10O2. In an article, author is Abouzid, Khaled A. M.,once mentioned of 122-99-6, Quality Control of 2-Phenoxyethanol.

Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines

A series of new phthalazine derivatives 3a-i and 4a-c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a-c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 mu mol.

If you’re interested in learning more about 122-99-6. The above is the message from the blog manager. Quality Control of 2-Phenoxyethanol.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 122-99-6, Name is 2-Phenoxyethanol, molecular formula is C8H10O2, belongs to phthalazine compound, is a common compound. In a patnet, author is Cabeza, Javier A., once mentioned the new application about 122-99-6, Name: 2-Phenoxyethanol.

Reactions of phthalazine, quinazoline, 4,7-phenanthroline and 2,3 ‘-bipyridine with ruthenium carbonyl

The reactions of [Ru-3(CO)(12)] with four aromatic diazines have been studied in THF at reflux temperature. With phthalazine (L-1), the compound [Ru-3(mu-kappa(NN3)-N-2-N-2-L-1)(mu-CO)(3)(CO)(7)] (1), which contains an intact phthalazine ligand in an axial position bridging an Ru-Ru edge through both N atoms, is initially formed but it reacts with more phthalazine to give [Ru-3(kappa N-2-L-1)(mu-kappa(NN3)-N-2-N-2-L-1)(mu-CO)(3)(CO)(6)] (2), in which a pi-pi stacking interaction between the aromatic rings of both ligands determines their position in cluster axial sites on the same face of the Ru3 triangle. With quinazoline (HL2), the cyclometalated hydrido decacarbonyl derivative [Ru-3(mu-H)(mu-kappa(NC4)-N-2-C-3-L-2)(CO)(10)] (3) is initially produced but it partially decarbonylates under the reaction conditions to give [Ru-6(mu-H)(2)(mu-kappa(NC4)-N-2-C-3-L-2)(mu(3)-kappa(3)-(NNC4)-N-1-C-3-L-2)(CO)(19)] (4), which results from the displacement of a CO ligand of 3 by the uncoordinated N-1 atom of another molecule of 3. With 4,7-phenanthroline (H2L3), the stepwise formation of the cyclometalated derivatives [Ru-3(mu-H)(mu-kappa(NC3)-N-2-C-4-HL3)(CO)(10)] (5) and two isomers of [Ru-6(mu-H)(2)(mu(4)-kappa(NCNC8)-N-4-C-4-N-3-C-7-L-3)(CO)(20)] (6a, 6b) takes place. In compounds 6a and 6b, two Ru-3(mu-H)(CO)(10) trinuclear units are symmetrically (C-2 in 6a or C-S in 6b) bridged by a doubly-cyclometalated 4,7-phenanthroline ligand. With 2,3′-bipyridine (HL4), two products have been isolated, [Ru-3(mu-H)(mu-kappa N-2(3)’ C-4′-L-4)(CO)(10)] (7) and [Ru-3(mu-H)-(mu-kappa(NN3)-N-3-N-2’C-2′-L-4)(CO)(9)] (8). While compound 7 contains an N-3′ C-4′-cyclometalated 2,3′-bipyridine, in compound 8 an N-3′ C-2′-cyclometalation is accompanied by the coordination of the N-2 atom of the remaining pyridine fragment. The structures of compounds 2, 3, 4, 6a and 8 have been determined by X-ray diffraction crystallography.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem