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We have studied the catalytic ability of copper(II) acetate monohydrate as a mild, environmentally benign, natural and economical catalyst for the multi-component efficient synthesis of biologically active spiro-4H-pyran derivatives and 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives with excellent yields and short reaction times. The most important advantages of this procedure are its mild, non-toxic and inexpensive catalyst, one-pot synthesis, environmentally benign nature, solvent-free conditions, simple operational procedures, and highly efficient conditions. [GRAPHICS] .

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

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Nanostructured SiO2-H2SO4 as an efficient and nano catalyst for one-pot synthesis of phtahalazines via three-component condensation of an aromatic or aliphatic aldehyde, malononitrile and 5-amino-2,3-dihydro-phthalazine-1,4-dione. Nanostructured SiO2-H2SO4 was synthesized and characterized via FT-IR and SEM techniques. It is rapid and efficient catalyst for one-pot synthesis of the biologically important 3,9-diamino-5,10-dioxo-1-aryl-5,10-dihydropyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives. The significant features of this methodology are nontoxic catalyst, short reaction time (10 min), recyclability, low catalyst loading, green organic solvent (ethanol), and avoiding tedious purification step.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

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Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to phthalazine compound. In a document, author is Patil, Smita, introduce the new discover, Recommanded Product: 1439-36-7.

A new phthalazine based chemosensor 3 was developed for the highly selective and sensitive detection of Co2+ in the mixed solvent system, CH3CN- H2O ( 1 : 1, v/ v). In the presence of Co2+, the colour of the solution 3 changed from yellow to green; the absorption maxima of 3 was red- shifted from 383 nm to 435 nm, and the fluorescence of 3 at 550 nm was significantly enhanced. The sensor 3 showed a detection limit down to 25 nM by forming a complex species with Co2+ in 1 : 1 stoichiometry. Furthermore, by means of confocal laser scanning microscopy experiments, it has demonstrated that it can be used as a fluorescent probe for monitoring Co2+ in living cells.

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Phthalazine – Wikipedia,
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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Thi Minh Ha Vuong, once mentioned the application of 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, molecular formula is C21H19OP, molecular weight is 318.35, MDL number is MFCD00008774, category is phthalazine. Now introduce a scientific discovery about this category, Safety of 1-(Triphenylphosphoranylidene)propan-2-one.

Blue highly fluorescent boron difluoride complexes based on phthalazine-pyridine

Three new boron difluoride complexes based on phthalazine-pyridine, denoted (6), (7) and (8), have been synthesized and their photophysical and electrochemical properties have been studied. Solutions of these new BF2-complexes exhibit an intense blue fluorescence under UV light at low concentrations. Fluorescence quantum yields (QYs) have been determined by photoluminescence (PL) spectroscopy and decay times (tau) by semi-empirical methods. QYs of (6), (7) and (8) vary from 25% to 79%. HOMO and LUMO energy levels have been estimated by cyclic voltammetry and PL spectroscopy. The HOMO and LUMO energy levels, at similar to -5.3 eV and similar to -2.3 eV, respectively, make these new complexes interesting candidates as blue emitters in OLED applications.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

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Reference of 1439-36-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to phthalazine compound. In a article, author is Shi, Xin, introduce new discover of the category.

A Green Synthesis of Highly Functionalized 3-amino-2-phenylsulfonyl-1-alkyl/aryl-1H-pyrazolo[1,2-b]phthalazine-5,10-diones and Their Reduction and Photophysical Studies

3-Amino-2-benzenesulfonyl-1-alkyl/aryl-1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives were synthesized by the one-pot, three-component condensation of phthalhydrazide, aldehydes, and (phenylsulfonyl)acetonitrile in EtOH using 2-hydroxyethylammonium acetate as catalyst. The advantages of this method include environmental friendliness, easy work-up, and excellent yields. The reduction of some products and photophysical properties were also investigated.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Extracurricular laboratory: Discover of C21H19OP

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1439-36-7 is helpful to your research. COA of Formula: C21H19OP.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, belongs to phthalazine compound. In a document, author is Jalili-Baleh, Leili, introduce the new discover, COA of Formula: C21H19OP.

New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer’s disease

A novel series of tacrine-like compounds 7a-u possessing a fused pyrazolo[1,2-b]phthalazine structure were designed and synthesized as potent and selective inhibitors of AChE. The in-vitro biological assessments demonstrated that several compounds had high anti-AChE activity at nano-molar level. The more promising compound 71 with IC50 of 49 nM was 7-fold more potent than tacrine and unlike tacrine, it was highly selective against AChE over BuChE. The cell-based assays against hepatocytes (HepG2) and neuronal cell line (PC12) revealed that 71 had significantly lower hepatotoxicity compared to tacrine, with additional neuroprotective activity against H2O2-induced damage in PC12 cells. This compound could also inhibit AChE-induced and self-induced A beta peptide aggregation. The advantages including synthetic accessibility, high potency and selectivity, low toxicity, adjunctive neuroprotective and A beta aggregation inhibitory activity, make this compound as a new multifunctional lead for Alzheimer’s disease drug discovery. (C) 2017 Elsevier Masson SAS. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, molecular formula is C21H19OP. In an article, author is Maheswari, Cinnathambi Subramani,once mentioned of 1439-36-7, Name: 1-(Triphenylphosphoranylidene)propan-2-one.

SnO2 nanoparticles as an efficient heterogeneous catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones

A new protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives is described via a one-pot three-component condensation reaction of phthalhydrazide, dimedone or 1,3-cyclohexanedione and aromatic aldehydes catalyzed by SnO2 nanoparticles as a heterogeneous catalyst under solvent-free conditions. The SnO2 nanoparticles (NPs) were characterized by FT-IR, X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and energy dispersive X-ray analyzer (EDAX). The advantages of the protocol are the shorter reaction time, simple work-up procedure and reusable catalyst. [GRAPHICS] .

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

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Synthesis, structure and DFT calculation of a facial tris-cyclometalated phosphorescent iridium(III) complex containing substituted phthalazine ligands

The facial tris-cyclometalated iridium(III) complex fac-Ir(dmpopopz)(3) (dmpopopzH = 1-(2,6-dimethylphenyloxy)-4-(4-phenyloxyphenyl)-phthalazine) was synthesized from the reaction of iridium (III) chloride hydrate and ligand dmpopopzH in refluxing ethoxyethanol. The conformation of complex fac-Ir(dmpopopz)(3) is described on the basis of the H-1 NMR, C-13 NMR, FT-IR and mass spectroscopies, the crystal structure of fac-Ir(dmpopopz)(3) was determined by X-ray crystallography, and the theoretical calculation of complex fac-Ir(dmpopopz)(3) was also investigated by the DFT method. The absorption and emission spectral results exhibit that complex fac-[Ir(dmpopopz)(3)] may be used as a red-emitting phosphorescent material. Efficient OLEDs have been achieved using the complex fac-[Ir(dmpopopz)(3)] in the red-emitting region. (C) 2017 Published by Elsevier B.V.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

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Phosphoramidates as Transient Precursors of Nitrogen-Centered Radical Under Visible-Light Irradiation: Application to the Synthesis of Phthalazine Derivatives

Phosphoramidates are for the first time presented as efficient N-Centered Radical (NCR) precursors under visible-light irradiation. More precisely among this class of phosphorus-derived compounds, we studied the radical reactivity of phosphonohydrazones, under mild reaction conditions, which allowed the synthesis of a wide and diversified library of the scarcely reported phthalazine scaffold. Mechanistic investigations confirmed the formation of a NCR from these brand-new phosphonohydrazones (derivatived from phosphoramidates), which were further engaged in an intramolecular 6-exo-dig cyclization to provide phthalazines. Compared to other pre-activated moieties, the phosphoramidate group is self-immolative, thus enhancing its attractiveness for the C-N bond formation.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

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Synthesis and Antimicrobial Activity of Some Condensed [4-(2,4,6-Trimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic Acid Hydrazide

Some new 1,2,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-2,4,6-trimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR, 1H NMR, 13C NMR, MS and elemental analysis. The new compounds were synthesized with the objective of studying their antimicrobial activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem