Category: 19064-74-5

19064-74-5, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.6-Bromophthalazine, cas is 19064-74-5,the phthalazine compound. Here is a downstream synthesis route of the compound 19064-74-5

EXAMPLE 40; N-(2-chloro-5-(6-phthalazinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide; A suspension of N-(2-chloro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (102 mg, 247 mumol), 6-bromophthalazine (43 mg, 206 mumol), dichloro[l,rbis(diphenylphoshino)ferrocene]palladium(II)dichloromethane adduct (11 mg, 15 mumol), and Na2CO3 (65 mg, 617 mumol) in 1,4-dioxane (2 mL) and water (1 mL) was sparged with nitrogen for 5 minutes, then heated to 100 0C for 2 hours. The reaction was then partitioned between 9: 1 CHC13/IPA (30 mL) and 5% NaHCO3 (10 mL). The separated organic was dried over Na2SO4, concentrated onto dry silica, and then purified on silica eluting with 2- >5% of MeOH/DCM. Product was isolated as light yellow solid. MS (ESI pos. ion) m/z calc’d for Ci9H12ClFN4O2S: 414.0; found 415.0. 1H NMR (400 MHz, DMSO-d6) delta 7.44 (t, J=8.8 Hz, 2 H) 7.80 – 7.87 (m, 2 H) 8.24 (d, J=2.1 Hz, 1 H) 8.32 (d, J=8.4 Hz, 1 H) 8.38 (dd, J=8.7, 2.0 Hz, 1 H) 8.54 (s, 1 H) 8.79 (d, J= 2.1 Hz, 1 H) 9.76 (s, 2 H) 10.60 (s, 1 H).

19064-74-5, There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 19064-74-5

Reference£º
Patent; AMGEN INC.; WO2009/155121; (2009); A2;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

19064-74-5, We know that the rate of many reactions can be accelerated by catalysts. A catalyst speeds up the rate of a reaction by lowering the activation energy; in addition, the catalyst is regenerated in the process. 6-Bromophthalazine, cas is 19064-74-5,the phthalazine compound, below Introduce a new synthetic route.

A mixture of 6-bromophthalazine (0.11 g, 0.50 mmol), 6-chloro-N-methyi-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine (0.16 g, 0.58 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2’bi(1 ,3,2-dioxaborolane) (0.14 g, 0.55 mmol), potassium acetate (0.15 g, 1.5 mmol) and [1, 1 ‘bis(diphenylphosphino)ferrocene]dichloropalladium(ll), complex with dichloromethane (0.04 g, 0.05mmol) in dioxane (3 ml) was heated at 80 oc for 3 h. Potassium carbonate (0.20 g, 1.5 mmol) and10 water (0.4 ml) were added and the mixture was stirred for 48 hat 90 C. After cooling, the reactionwas purified by solid phase extraction (SiliaBond Carbonate, MeOH as eluent). After evaporationof the solvent under reduced pressure, the material afforded was purified via reverse phasepreparative HPLC using 5 to 95% acetonitrile in water modified with 3% n-PrOH. LCMS: Rt = 0.43min [M+H] (LCMS method Q); 377.245; 1H NMR (400 MHz, DMSO-d6) o 9.74-9.62 (m, 2H), 8.7515 (s, 1H), 8.74 (dd, J= 8.5, 2.0 Hz, 1H), 8.23 (d, J= 8.5 Hz, 1H), 8.12 (d, J= 9.5 Hz, 1H), 7.19 (d, J=9.5 Hz, 1H), 5.19 (tt, J= 12.0, 3.5 Hz, 1H), 2.98 (s, 3H), 1.56 (dd, J= 12.0, 3.5 Hz, 2H), 1.45 (t, J=12.0 Hz, 2H), 1.27 (s, 6H), 1.10 (s, 6H).

Any one of these steps may be slow and thus may serve as the rate determining step. In general, however, in the presence of the catalyst, the overall rate of the reaction is faster than it would be if the reactants were in the gas or liquid phase., 19064-74-5

Reference£º
Patent; NOVARTIS AG; CHEUNG, Atwood; CHIN, Donovan Noel; DALES, Natalie; FAZAL, Aleem; HURLEY, Timothy Brian; KERRIGAN, John; O’BRIEN, Gary; SHU, Lei; SUN, Robert; SUNG, Moo; WO2014/28459; (2014); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. 19064-74-5, If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.6-Bromophthalazine, cas is 19064-74-5,the phthalazine compound. A new synthetic method of this compound is introduced below.

Example 154 Synthesis of 5′-((3-endo)-3-amino-8-azabicyclo[3.2.1]octane-8-carbonyl)-3-fluoro-2′-(phthalazin-6-yl)-[1,1′-biphenyl]-4-carbonitrile The procedure of steps 1 to 5 in Example 41 was conducted using 6-bromophthalazine instead of 1-(4-bromo-3-fluoro-phenyl)-2-methyl-propan-2-ol to give the title compound.

19064-74-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,19064-74-5 ,6-Bromophthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Taiho Pharmaceutical Co., Ltd.; OSADA, Akiko; EP3632443; (2020); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. 19064-74-5, If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.6-Bromophthalazine, cas is 19064-74-5,the phthalazine compound. A new synthetic method of this compound is introduced below.

Example 17 N-(4-Methyl-3-phthalazin-6-yl-phenyl)-4-piperidin-1-ylmethyl-3-trifluoromethyl-benzamide Nitrogen is bubbled through a mixture of 0.295 g (0.648 mmol) N-(3-bromo-4-methyl-phenyl)-4-piperidin-1-ylmethyl-3-trifluoromethyl-benzamide, 0.191 g (1.94 mmol) potassium acetate and 0.198 g (0.778 mmol) bis-(pinacolato)-diboron in 3.12 mL DMF for about 10 minutes. After the addition of 0.032 g (0.0391 mmol) 1,1′-bis(diphenylphospino)ferrocene-palladium dichloride the mixture is heated to 80 C. for 6 h. The N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-4-piperidin-1-ylmethyl-3-trifluoromethyl-benzamide intermediate formed is not isolated. To the cooled dark suspension is added under nitrogen 6-bromophthalazine (0.1355 g, 0.648 mmol), caesium carbonate (0.316 g, 0.97 mmol) and 0.0225 mg (0.0195 mmol) tetrakis(triphenylphosphine)palladium. The dark mixture is heated to 80 C. for 15 h, cooled to rt and filtered. The solids are washed with DMF and the combined filtrates are evaporated under reduced pressure. The residue is partitioned between ethyl acetate and saturated sodium bicarbonate solution and the organic phase washed with brine, dried with sodium sulphate and evaporated. The crude product is purified by chromatography using a 40 g silica gel column on a Combi-Flash Companion (Isco Inc.) apparatus. A gradient of ethyl acetate/methanol (0?10% methanol) is used. Pure fractions are pooled and evaporated to give the title compound as tan crystals; m.p. 175-177 C.; Rf (ethyl acetate/methanol 9:1)=0.39; HPLC tR=2.50 min; MS-ES+: (M+H)+=505.

19064-74-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,19064-74-5 ,6-Bromophthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Caravatti, Giorgio; Furet, Pascal; Imbach, Patricia; Martiny-Baron, Georg; Perez, Lawrence Blas; Sheng, Tao; US2006/35897; (2006); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is 6-Bromophthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 19064-74-5, its synthesis route is as follows.

Example 154 Synthesis of 5′-((3-endo)-3-amino-8-azabicyclo[3.2.1]octane-8-carbonyl)-3-fluoro-2′-(phthalazin-6-yl)-[1,1′-biphenyl]-4-carbonitrile The procedure of steps 1 to 5 in Example 41 was conducted using 6-bromophthalazine instead of 1-(4-bromo-3-fluoro-phenyl)-2-methyl-propan-2-ol to give the title compound.

19064-74-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,19064-74-5 ,6-Bromophthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Taiho Pharmaceutical Co., Ltd.; OSADA, Akiko; EP3632443; (2020); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is 6-Bromophthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 19064-74-5, its synthesis route is as follows.

Example 17 N-(4-Methyl-3-phthalazin-6-yl-phenyl)-4-piperidin-1-ylmethyl-3-trifluoromethyl-benzamide Nitrogen is bubbled through a mixture of 0.295 g (0.648 mmol) N-(3-bromo-4-methyl-phenyl)-4-piperidin-1-ylmethyl-3-trifluoromethyl-benzamide, 0.191 g (1.94 mmol) potassium acetate and 0.198 g (0.778 mmol) bis-(pinacolato)-diboron in 3.12 mL DMF for about 10 minutes. After the addition of 0.032 g (0.0391 mmol) 1,1′-bis(diphenylphospino)ferrocene-palladium dichloride the mixture is heated to 80 C. for 6 h. The N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-4-piperidin-1-ylmethyl-3-trifluoromethyl-benzamide intermediate formed is not isolated. To the cooled dark suspension is added under nitrogen 6-bromophthalazine (0.1355 g, 0.648 mmol), caesium carbonate (0.316 g, 0.97 mmol) and 0.0225 mg (0.0195 mmol) tetrakis(triphenylphosphine)palladium. The dark mixture is heated to 80 C. for 15 h, cooled to rt and filtered. The solids are washed with DMF and the combined filtrates are evaporated under reduced pressure. The residue is partitioned between ethyl acetate and saturated sodium bicarbonate solution and the organic phase washed with brine, dried with sodium sulphate and evaporated. The crude product is purified by chromatography using a 40 g silica gel column on a Combi-Flash Companion (Isco Inc.) apparatus. A gradient of ethyl acetate/methanol (0?10% methanol) is used. Pure fractions are pooled and evaporated to give the title compound as tan crystals; m.p. 175-177 C.; Rf (ethyl acetate/methanol 9:1)=0.39; HPLC tR=2.50 min; MS-ES+: (M+H)+=505.

19064-74-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,19064-74-5 ,6-Bromophthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Caravatti, Giorgio; Furet, Pascal; Imbach, Patricia; Martiny-Baron, Georg; Perez, Lawrence Blas; Sheng, Tao; US2006/35897; (2006); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

19064-74-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6-Bromophthalazine, cas is 19064-74-5,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

A glass microwave reaction vessel was charged with 6-bromophthalazine (1.0 g, 5 mmol), tert-butyl 5-(tributylstannyl)thiazol-2-ylcarbamate (4.0 g, 7 mmol), DMF (4 mL), cesium fluoride (1.0 g, 10 mmol), copper(I) iodide (0.2 g, 1.0 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.3 g, 0.2 mmol). The reaction mixture was stirred and heated at 100 C. overnight. The mixture was diluted with DCM (20 mL) and water (5 mL) and filtered through Celite. The organic solution was evaporated under reduced pressure, and the residue was adsorbed onto a plug of silica gel and chromatographed through a Redi-Sep pre-packed silica gel column (40 g), eluting with a gradient of 5% to 10% MeOH in DCM to provide the title compound (1.19 g, 76%). LCMS (M+H+) 329.3 calc. for C16H16N4O2S 329.3; 1H NMR (400 MHz, CDCl3) delta ppm 9.50 (s, J=13.69 Hz 1H), 9.46 (s, 1H), 8.01 (d, J=1.37, Hz 1H), 7.92 (d, J=8.41 Hz, 1H), 7.81 (s, 1H), 7.58 (s, 1H) 1.40 (s, 9H).

The chemical industry reduces the impact on the environment during synthesis,19064-74-5,6-Bromophthalazine,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; AMGEN INC.; US2007/173506; (2007); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is 6-Bromophthalazine, and cas is 19064-74-5, its synthesis route is as follows.

EXAMPLE 40; N-(2-chloro-5-(6-phthalazinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide; A suspension of N-(2-chloro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (102 mg, 247 mumol), 6-bromophthalazine (43 mg, 206 mumol), dichloro[l,rbis(diphenylphoshino)ferrocene]palladium(II)dichloromethane adduct (11 mg, 15 mumol), and Na2CO3 (65 mg, 617 mumol) in 1,4-dioxane (2 mL) and water (1 mL) was sparged with nitrogen for 5 minutes, then heated to 100 0C for 2 hours. The reaction was then partitioned between 9: 1 CHC13/IPA (30 mL) and 5% NaHCO3 (10 mL). The separated organic was dried over Na2SO4, concentrated onto dry silica, and then purified on silica eluting with 2- >5% of MeOH/DCM. Product was isolated as light yellow solid. MS (ESI pos. ion) m/z calc’d for Ci9H12ClFN4O2S: 414.0; found 415.0. 1H NMR (400 MHz, DMSO-d6) delta 7.44 (t, J=8.8 Hz, 2 H) 7.80 – 7.87 (m, 2 H) 8.24 (d, J=2.1 Hz, 1 H) 8.32 (d, J=8.4 Hz, 1 H) 8.38 (dd, J=8.7, 2.0 Hz, 1 H) 8.54 (s, 1 H) 8.79 (d, J= 2.1 Hz, 1 H) 9.76 (s, 2 H) 10.60 (s, 1 H).

19064-74-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,19064-74-5 ,6-Bromophthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; AMGEN INC.; WO2009/155121; (2009); A2;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

19064-74-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6-Bromophthalazine, cas is 19064-74-5,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 6-bromophthalazine (0.11 g, 0.50 mmol), 6-chloro-N-methyi-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine (0.16 g, 0.58 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2’bi(1 ,3,2-dioxaborolane) (0.14 g, 0.55 mmol), potassium acetate (0.15 g, 1.5 mmol) and [1, 1 ‘bis(diphenylphosphino)ferrocene]dichloropalladium(ll), complex with dichloromethane (0.04 g, 0.05mmol) in dioxane (3 ml) was heated at 80 oc for 3 h. Potassium carbonate (0.20 g, 1.5 mmol) and10 water (0.4 ml) were added and the mixture was stirred for 48 hat 90 C. After cooling, the reactionwas purified by solid phase extraction (SiliaBond Carbonate, MeOH as eluent). After evaporationof the solvent under reduced pressure, the material afforded was purified via reverse phasepreparative HPLC using 5 to 95% acetonitrile in water modified with 3% n-PrOH. LCMS: Rt = 0.43min [M+H] (LCMS method Q); 377.245; 1H NMR (400 MHz, DMSO-d6) o 9.74-9.62 (m, 2H), 8.7515 (s, 1H), 8.74 (dd, J= 8.5, 2.0 Hz, 1H), 8.23 (d, J= 8.5 Hz, 1H), 8.12 (d, J= 9.5 Hz, 1H), 7.19 (d, J=9.5 Hz, 1H), 5.19 (tt, J= 12.0, 3.5 Hz, 1H), 2.98 (s, 3H), 1.56 (dd, J= 12.0, 3.5 Hz, 2H), 1.45 (t, J=12.0 Hz, 2H), 1.27 (s, 6H), 1.10 (s, 6H).

The chemical industry reduces the impact on the environment during synthesis,19064-74-5,6-Bromophthalazine,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; NOVARTIS AG; CHEUNG, Atwood; CHIN, Donovan Noel; DALES, Natalie; FAZAL, Aleem; HURLEY, Timothy Brian; KERRIGAN, John; O’BRIEN, Gary; SHU, Lei; SUN, Robert; SUNG, Moo; WO2014/28459; (2014); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is 6-Bromophthalazine, and cas is 19064-74-5, its synthesis route is as follows.,19064-74-5

Example 17 N-(4-Methyl-3-phthalazin-6-yl-phenyl)-4-piperidin-1-ylmethyl-3-trifluoromethyl-benzamide Nitrogen is bubbled through a mixture of 0.295 g (0.648 mmol) N-(3-bromo-4-methyl-phenyl)-4-piperidin-1-ylmethyl-3-trifluoromethyl-benzamide, 0.191 g (1.94 mmol) potassium acetate and 0.198 g (0.778 mmol) bis-(pinacolato)-diboron in 3.12 mL DMF for about 10 minutes. After the addition of 0.032 g (0.0391 mmol) 1,1′-bis(diphenylphospino)ferrocene-palladium dichloride the mixture is heated to 80 C. for 6 h. The N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-4-piperidin-1-ylmethyl-3-trifluoromethyl-benzamide intermediate formed is not isolated. To the cooled dark suspension is added under nitrogen 6-bromophthalazine (0.1355 g, 0.648 mmol), caesium carbonate (0.316 g, 0.97 mmol) and 0.0225 mg (0.0195 mmol) tetrakis(triphenylphosphine)palladium. The dark mixture is heated to 80 C. for 15 h, cooled to rt and filtered. The solids are washed with DMF and the combined filtrates are evaporated under reduced pressure. The residue is partitioned between ethyl acetate and saturated sodium bicarbonate solution and the organic phase washed with brine, dried with sodium sulphate and evaporated. The crude product is purified by chromatography using a 40 g silica gel column on a Combi-Flash Companion (Isco Inc.) apparatus. A gradient of ethyl acetate/methanol (0?10% methanol) is used. Pure fractions are pooled and evaporated to give the title compound as tan crystals; m.p. 175-177 C.; Rf (ethyl acetate/methanol 9:1)=0.39; HPLC tR=2.50 min; MS-ES+: (M+H)+=505.

With the complex challenges of chemical substances, we look forward to future research findings about 19064-74-5,belong phthalazine compound

Reference£º
Patent; Caravatti, Giorgio; Furet, Pascal; Imbach, Patricia; Martiny-Baron, Georg; Perez, Lawrence Blas; Sheng, Tao; US2006/35897; (2006); A1;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem