Category: 24324-17-2

In an article, author is Sanchez-Moreno, Manuel, once mentioned the application of 24324-17-2, Quality Control of 9-Fluorenemethanol, Name is 9-Fluorenemethanol, molecular formula is C14H12O, molecular weight is 196.2445, MDL number is MFCD00001139, category is phthalazine. Now introduce a scientific discovery about this category.

Objectives: To evaluate the in vitro leishmanicidal activity of imidazole-based (1-4) and pyrazole-based (5-6) benzo[g] phthalazine derivatives against Leishmania infantum and Leishmania braziliensis. Methods: The in vitro activity of compounds 1-6 was assayed on extracellular promastigote and axenic amastigote forms, and on intracellular amastigote forms of the parasites. Infectivity and cytotoxicity tests were performed on J774.2 macrophage cells using meglumine antimoniate (Glucantime) as the reference drug. The mechanisms of action were analysed by iron superoxide dismutase (Fe-SOD) and copper/zinc superoxide dismutase (CuZn-SOD) inhibition, metabolite excretion and transmission electronic microscopy (TEM). Results: Compounds 1-6 were more active and less toxic than meglumine antimoniate. Data on infection rates and amastigote mean numbers showed that 2, 4 and 6 were more active than 1, 3 and 5 in both L. infantum and L. braziliensis. The inhibitory effect of these compounds on the antioxidant enzyme Fe-SOD of promastigote forms of the parasites was remarkable, whereas inhibition of human CuZn-SOD was negligible. The ultrastructural alterations observed in treated promastigote forms confirmed the greater cell damage caused by the most active compounds 2, 4 and 6. The modifications observed by 1H-NMR in the nature and amounts of catabolites excreted by the parasites after treatment with 1-6 suggested that the catabolic mechanisms could depend on the structure of the side chains linked to the benzo[g] phthalazine moiety. Conclusions: All the compounds assayed were active in vitro against the two Leishmania species and were less toxic against mammalian cells than the reference drug, but the monosubstituted compounds were significantly more effective and less toxic than their disubstituted counterparts.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 24324-17-2, Name is 9-Fluorenemethanol, formurla is C14H12O. In a document, author is Mohammad, Faruq, introducing its new discovery. Computed Properties of https://www.ambeed.com/products/24324-17-2.html.

In this, we performed a four component domino reaction of phthaloyl dichloride, hydrazine hydrate, indole-3-carboxaldehydes and malononitrile/ethyl cyanoacetate to form 1-(1H-indol-2-yl)-1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives by in situ generation of HCl as catalyst in refluxing ethanol for 1 h in good yields. This four component domino reaction transformation presumably proceeds via addition/dehydrohalogenation/condensation/cyclization of reactions. The material was thoroughly characterized at various stages of its formation by means of FTIR, NMR spectroscopic and Mass spectrometric analysis and is confirmed to be the derivative of 1-(1H-indo1-2-yl)-1H-pyrazolo [1,2-b]phthalazine-5,10-dione.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 24324-17-2 help many people in the next few years. Computed Properties of https://www.ambeed.com/products/24324-17-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Saha, Mithu, once mentioned the application of 24324-17-2, Application In Synthesis of 9-Fluorenemethanol, Name is 9-Fluorenemethanol, molecular formula is C14H12O, molecular weight is 196.2445, MDL number is MFCD00001139, category is phthalazine. Now introduce a scientific discovery about this category.

A nickel nanoparticle (NPs) catalyzed one-pot three component reaction of phthalhydrazide, dimedone and aryl aldehydes under solvent free conditions has been reported. The present approach offers the advantages of simple methodology, clean and mild reaction conditions, short reaction time, low environmental impact, high yield, and excellent purity. The synthesized compounds (2H-indazolo[2,1-b] phthalazine-trione) are found to be suitable candidates for efficient fluorogenic assays to monitor bio-chemical environments.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is VirupakshiPrabhakar, once mentioned the application of 24324-17-2, Safety of 9-Fluorenemethanol, Name is 9-Fluorenemethanol, molecular formula is C14H12O, molecular weight is 196.2445, MDL number is MFCD00001139, category is phthalazine. Now introduce a scientific discovery about this category.

The article is aimed to synthesize, characterize and screening the biological activity of novel a series of 6-(Thiophen-3-Yl)-3-Para-Substituted-[1,2,4] Triazolo[3,4-a] Phthalazine Derivatives (8 a-j) with good yields. The newly synthesized compounds were characterized by IR, H-1-NMR, C-13 NMR and Mass spectral data. The anti-microbial activity of the novel compounds were screened by disc diffusion method. Compounds 8h, 8g, and 8f demonstrated good antimicrobial activity against all the tested microbial strains. FusedPhialazine 1, 2,4 Triazole linked thiophene with 2,5 di fluoro nucleus has shown good antibacterial and antifungal activities.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

24324-17-2, Name is 9-Fluorenemethanol, molecular formula is C14H12O, belongs to phthalazine compound, is a common compound. In a patnet, author is Orue, Analia Ivanna Chamorro, once mentioned the new application about 24324-17-2, SDS of cas: 24324-17-2.

An Experimental and Theoretical Approach to Control Salt vs Cocrystal vs Hybrid Formation-Crystal Engineering of an E/Z-Butenedioic Acid/Phthalazine System

The understanding and control of proton transfer reactions between acid-base pairs in the solid state are two of the main challenges for the crystal engineering community. The ability to control proton transfer reactions in the solid state enables a more selective preparation of cocrystals and salts, which facilitates the design of solid materials with specific physicochemical properties. In this study, an approach to control proton transfer reactions of an E-butenedioic acid/phthalazine cocrystal-salt (hybrid) system is presented, which allows the selective formation of its cocrystal and salt. In this approach the dominant intermolecular interactions between acid-base pairs are identified. Such interactions appear to be crucial for the inhibition or promotion of proton transfers in the solid state. For this, the relationship between these interactions and the so-called ApKa rule has been investigated.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 24324-17-2, 24324-17-2, Name is 9-Fluorenemethanol, SMILES is C1=CC=CC3=C1C2=CC=CC=C2C3CO, belongs to phthalazine compound. In a document, author is Etinski, Mihajlo, introduce the new discover.

A theoretical study of low-lying singlet and triplet excited states of quinazoline, quinoxaline and phthalazine: insight into triplet formation

Quinazoline, quinoxaline and phthalazine are nitrogen containing heterocyclic aromatic molecules which belong to the class diazanaphthalenes. These isomers have low-lying n pi(star) and naphthalene-like pi pi(star) states that interact via spin-orbit coupling. In this contribution, we study their structure and electronic states by means of a coupled-cluster method. The computed properties are compared to those of cinnoline which were obtained in our previous study [Etinski et al., Phys. Chem. Chem. Phys., 2014, 16, 4740]. The excited state features of these isomers are dependent on the position of the nitrogen atoms. We find that quinazoline and quinoxaline exhibit similarities in the ordering and character of the excited states. In contrast, a marked difference in the electronic and geometric structures of the lowest excited triplet states of cinnoline and phthalazine is noticed, although both are orthodiazanaphthalenes. Our findings suggest that the S-1 (sic) T-1 channel is responsible for the rapid intersystem crossing in quinazoline and quinoxaline, whereas the S-1 (sic) T-2 pathway is active in phthalazine.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 24324-17-2. Product Details of 24324-17-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem