Category: 24324-17-2

Application of 24324-17-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 24324-17-2, Name is 9-Fluorenemethanol, SMILES is C1=CC=CC3=C1C2=CC=CC=C2C3CO, belongs to phthalazines compound. In a article, author is Sherif, Yousery E., introduce new discover of the category.

Synthesis, characterization, analgesic and anti-inflammation activity of new phthalazines and their Cu(II) and Zn(II) complexes

1,4-Dioxo-3, 4, 4e, 5, 10, 10a-hexahydro-1H-5,10-benzenobenzo [g] phthalazin-2-yl-thioamide [6a]; 1,4-dioxo-3, 4, 4e, 5, 10, 10a-hexahydro-1H-5, 10-benzenobenzo [g] phthalazin-2-yl-N-pyridylthioamide [6b] and 1,4-dioxo-3, 4, 4e, 5, 10, 10a-hexahydro-1H-5, 10-benzenobenzo[g]phthalazin-2-yl-N-ethylthioamide [6c] and their [Cu(6a-H)(OAc)], [Zn(6a-H)(OAc)], [Cu(6b-H)(H2O)(2)(OAc)]center dot 3H(2)O and [Zn(6b-H)(OAc)], [Cu-2(6c-H)](OAc)(3)]center dot 2H(2)O and [Zn(6c-H)(OAc)] complexes have been synthesized via a reaction between phthalazinedione 6a-c derivatives and the acetate salt of Cu(II) or Zn(II). These compounds were characterized by elemental analysis, spectra (UV-Vis, IR, H-1 NMR, C-13 NMR, ESR), conductance, thermal analysis and magnetic moments.

Application of 24324-17-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 24324-17-2 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Product Details of 24324-17-2, 24324-17-2, Name is 9-Fluorenemethanol, SMILES is C1=CC=CC3=C1C2=CC=CC=C2C3CO, in an article , author is El-Helby, Abdel-Ghany A., once mentioned of 24324-17-2.

Phthalazine-1,4-dione derivatives as non-competitive AMPA receptor antagonists: design, synthesis, anticonvulsant evaluation, ADMET profile and molecular docking

In view of the anticonvulsant activity reported for phthalazine derivatives as non-competitive AMPA receptor antagonists, a new series of phthalazine-1,4-diones (2-12) were designed and synthesized. The neurotoxicity was assessed using rotarod test. The molecular docking was performed for the synthesized compounds to assess their binding affinities toward AMPA receptor as non-competitive antagonists. The molecular modeling data were strongly interrelated to biological screening data. Compounds 8, 7(b), 7(a), 10 and 3(a) exhibited the highest binding affinities as non-competitive AMPA receptor antagonists and also showed the highest relative potencies of 1.78, 1.66, 1.60, 1.59 and 1.29, respectively, as anticonvulsants in comparison with diazepam. The most active compounds 8, 7(b), 7(a), 10 and 3(a) were further tested against maximal electroshock seizure (MES). Compounds 8 and 7(b) and 3(a) showed 100% protection at a dose level of 125 mu gm/kg, while compounds 7(a) and 10 exhibited 83.33% protection at the same dose level. These agents exerted low neurotoxicity and high safety margin in comparison with valproate as a reference drug. Most of our designed compounds exhibited good ADMET profile.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 24324-17-2, you can contact me at any time and look forward to more communication. Product Details of 24324-17-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Kiasat, Ali Reza, once mentioned the application of 24324-17-2, Name is 9-Fluorenemethanol, molecular formula is C14H12O, molecular weight is 196.2445, MDL number is MFCD00001139, category is phthalazines. Now introduce a scientific discovery about this category, Application In Synthesis of 9-Fluorenemethanol.

Experimental and theoretical study on one-pot, three-component route to 2H-indazolo[2,1-b]phthalazine-triones catalyzed by nano-alumina sulforic acid

A simple, efficient, and high yielding one-pot protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives has been developed by three-component coupling of phthalhydrazide, dimedone and some aromatic aldehydes in ecofriendly neat conditions promoted by nano-gamma-alumina sulforic acid. This protocol avoids the use of expensive catalysts, toxic solvents and chromatographic separation. Also the proposed protocol was extended to the linear beta-diketone (acetylaceton) instead of cyclic diketone (dimedone). The generality and functional tolerance of this convergent and environmentally benign method is demonstrated. The nature of each step of the suggested mechanism for this condensation reaction is also identified through Density Functional Theory (DFT) calculations using B3LYP/6-31G** level of theory. It is shown that the first step is charge controlled; whereas the second one is controlled by frontier molecular orbitals. The H-1 and C-13 chemical shift values together with the structural parameters of the title compound have been also computed and the scaled values have been compared with the corresponding experimental NMR and X-ray spectra. As a result, the calculated spectroscopic data and optimized geometry show a good agreement with the experimental results. (C) 2012 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem