Category: 253-52-1

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Generation of a new mouse model of glaucoma characterized by reduced expression of the AP-2beta and AP-2delta proteins

We generated 6 transgenic lines with insertion of an expression plasmid for the R883/M xanthine dehydrogenase (XDH) mutant protein. Approximately 20% of the animals deriving from one of the transgenic lines show ocular abnormalities and an increase in intra-ocular pressure which are consistent with glaucoma. The observed pathologic phenotype is not due to expression of the transgene, but rather the consequence of the transgene insertion site, which has been defined by genome sequencing. The insertion site maps to chromosome 1qA3 in close proximity to the loci encoding AP-2beta and AP-2delta, two proteins expressed in the eye. The insertion leads to a reduction in AP-2beta and AP-2delta levels. Down-regulation of AP-2beta expression is likely to be responsible for the pathologic phenotype, as conditional deletion of the Tfap2b gene in the neural crest has recently been shown to cause defective development of the eye anterior segment and early-onset glaucoma. In these conditional knock-out and our transgenic mice, the morphological/histological features of the glaucomatous pathology are surprisingly similar. Our transgenic mouse represents a model of angle-closure glaucoma and a useful tool for the study of the pathogenesis and the development of innovative therapeutic strategies.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N60 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of Phthalazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 253-52-1

Vibronic analyses of the lowest singlet-singlet and singlet-triplet band systems of pyridazine

The first singlet-singlet and singlet-triplet band systems of the absorption spectrum of pyridazine vapour are analysed using ab initio and vibronic coupling calculations. The lowest singlet-triplet absorption involves a comparatively unperturbed (pi(*),n)3B1 state, and contrasts with the highly perturbed singlet-singlet spectrum. The major source of vibronic perturbation in the singlet-singlet absorption is attributed to coupling between near-resonant (pi(*),n)1A2 and (pi(*),n)1B1 states, with the former being slightly lower in energy. Many features of this complex and unusual spectrum, and its associated single vibronic level fluorescence spectrum, can be explained using a simple vibronic model. This provides experimental support for recent relaxed CASPT2 and EOM-CCSD calculations, but contrasts with earlier assignments of the spectrum. Theory and experiment suggest that the spacing between the lowest A2 and B1 states is larger in the triplet manifold, leading to a simpler spectrum. (C) 2000 Published by Elsevier Science B.V.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N150 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 253-52-1, name is Phthalazine, introducing its new discovery. HPLC of Formula: C8H6N2

Investigating pyridazine and phthalazine exchange in a series of iridium complexes in order to define their role in the catalytic transfer of magnetisation from para-hydrogen

The reaction of [Ir(IMes)(COD)Cl], [IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene, COD = 1,5-cyclooctadiene] with pyridazine (pdz) and phthalazine (phth) results in the formation of [Ir(COD)(IMes)(pdz)]Cl and [Ir(COD)(IMes)(phth)]Cl. These two complexes are shown by nuclear magnetic resonance (NMR) studies to undergo a haptotropic shift which interchanges pairs of protons within the bound ligands. When these complexes are exposed to hydrogen, they react to form [Ir(H)2(COD)(IMes)(pdz)]Cl and [Ir(H)2(COD)(IMes)(phth)]Cl, respectively, which ultimately convert to [Ir(H)2(IMes)(pdz)3]Cl and [Ir(H)2(IMes)(phth)3]Cl, as the COD is hydrogenated to form cyclooctane. These two dihydride complexes are shown, by NMR, to undergo both full N-heterocycle dissociation and a haptotropic shift, the rates of which are affected by both steric interactions and free ligand pKa values. The use of these complexes as catalysts in the transfer of polarisation from para-hydrogen to pyridazine and phthalazine via signal amplification by reversible exchange (SABRE) is explored. The possible future use of drugs which contain pyridazine and phthalazine motifs as in vivo or clinical magnetic resonance imaging probes is demonstrated; a range of NMR and phantom-based MRI measurements are reported.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N40 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. HPLC of Formula: C8H6N2. Introducing a new discovery about 253-52-1, Name is Phthalazine

The reactions of 2-(chloroseleno)benzoyl chloride with pyridine and related azines

The reaction of 2-(chloroseleno)benzoyl chloride with pyridine and pyridine-like heterocycles such as pyrimidine, pyrazine, quinoline, phthalazine, phenazine and 1,10-phenanthroline was studied. In the most cases stable 2-(hydroxyseleno)benzoylazinium chlorides were produced depending on the number of the pyridinium-like nitrogen atoms and their situation in the ring system.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N327 – PubChem

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Surface-Enhanced Raman Spectra of Phthalazine. Anion-Induced Reorientation on a Silver Electrode

A remarkable potential-dependent SERS of phthalazine adsorbed on a silver electrode has been observed from a series of aqueous solutions containing Cl-, I-, Br-, F-, SCN-, SO42-, or ClO4- as electrolyte anion.The Raman intensity of certain b2 modes was greatly enhanced accompanied by anion desorption during the cathodic sweep.However, the b2 species were absent from the SER spectra when the surfaces were fully covered with anions.The specific adsorption of anions influences the orientations of the adsorbed phthalazine.The importance of the charge-transfer effect on SERS is also suggested from the potential and excitation-wavelength-dependent spectral changes.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N431 – PubChem

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Diazaarynes: 3,4- and 4,5-Didehydropyridazine By Electron Impact and Thermolytic Fragmentation of The Corresponding Dicarboxylic Anhydrides

The new hetarynes (1) and (2) heve been advanced as intermediates in the vapour phase both for the electron impact and the pyrolytic fragmentation pattern of pyridazine-3,4- and 4,5-dicarboxylic acid anhydrides (10) and (11), respectively.The presence of a peak at m/e 78 in the mass spectra of these compounds, as well as the formation of the diazanaphtalenes (12) and (13), respectively, from their thermolysis in benzene, appeared to support this proposal.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N412 – PubChem

253-52-1, Name is Phthalazine, belongs to phthalazine compound, is a common compound. Computed Properties of C8H6N2In an article, once mentioned the new application about 253-52-1.

Intramolecular Cyclization via Onium Salts. A Novel Synthesis of 1,3-Thiazolidines from Chloromethyl (Trimethylsilyl)methyl Sulfide and Nitrogen-Containing Heteroaromatic Compounds

Polycyclic 1,3-thiazolidines were prepared by the fluoride ion promoted desilylation, followed by intramolecular 1,5-cyclization, of onium salts derived from the sulfide 1 and a variety of heteroaromatics.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N189 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of Phthalazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 253-52-1, Name is Phthalazine, molecular formula is C8H6N2

Electrochemical Reductive Carboxylation: Reduction of Unsaturated Compounds in the Presence of Methyl Chloroformate

Mono- and dicarboxylated derivatives have been obtained by electroreduction of various unsaturated compounds in acetonitrile at a mercury-pool cathode in the presence of methyl chloroformate.Unsaturated compounds included activated olefins, ketones, aromatic Schiff bases, nitro compounds, and nitrogen heterocycles.The distribution of the products and their yields depend on the nature of the supporting electrolyte (Et4NClO4 or LiClO4).Reduction mechanisms accounting for the nature of the reduction products are proposed on the basis of voltammetric and coulometric data.In some cases it is possible to obtain the kinetic parameters.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of Phthalazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 253-52-1, in my other articles.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N42 – PubChem

Application of 253-52-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 253-52-1, Name is Phthalazine,introducing its new discovery.

Six-Membered Ring Systems: Diazines and Benzo Derivatives

Found in natural products, and frequently used as flavoring agents or as building blocks for pharmaceuticals, diazines and their benzo derivatives possess a diverse set of properties, allowing a broad range of applications, spanning from medicinal chemistry to electrochemistry. New diazine-based natural products continue to be isolated and studied. In addition, new syntheses, reactions, and applications of diazine-based compounds are reported every year. Recent advances in the development of new preparations, reactions, and applications of diazines and their benzo derivatives, published in the literature in 2018, are discussed in this review.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N364 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Computed Properties of C8H6N2. Introducing a new discovery about 253-52-1, Name is Phthalazine

An organocatalytic enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline: N -oxides

A new protocol for the enantioselective direct alpha-heteroarylation of aldehydes with isoquinoline N-oxides, via chiral enamine catalysis, has been successfully developed. High enantiomeric excesses and moderate to good yields were achieved for a variety of alpha-heteroarylated aldehydes.

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Phthalazine – Wikipedia,
Phthalazine | C8H6N74 – PubChem