Category: 253-52-1

253-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazine, cas is 253-52-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Phthalazine (1) (91 mg, 0.70 mmol), 1,1-dicyanoalkene 2(0.70 mmol), and isocyanide 3 (0.70 mmol) were dissolvedin acetonitrile (1 ml). After that, distilled water(0.05?0.1 ml) was added to the reaction mixture up tovisible turbidity and stirred at 25?30¡ãC for 12?18 h. Thereaction mixture was evaporated to dryness and product 4was purified by crystallization from ethanol.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Phthalazine, 253-52-1

Reference£º
Article; Mironov, Maxim A.; Shulepov, Iliya D.; Kozhikhova, Ksenia V.; Ivantsova, Maria N.; Tokareva, Maria I.; Chemistry of Heterocyclic Compounds; vol. 53; 4; (2017); p. 430 – 433; Khim. Geterotsikl. Soedin.; vol. 53; 4; (2017); p. 430 – 433,4;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazine, and cas is 253-52-1, its synthesis route is as follows.

General procedure: A solution of NH4SCN (0.10 g, 1.3 mmol) in water (10 ml) was slowly added to the methanolic solution (15 ml) of Cd(NO3)2¡¤4H2O (0.2 g; 0.65 mmol) and quinazoline (0.17 g; 1.3 mmol) and stirred at room temperature for 12 h. Yellow crystalline precipitate of [Cd(Qnz)2(SCN)2]n was filtered off, dried in air and collected in 75percent yield. The crystals suitable for X-ray structure determination were obtained by slow recrystallization from methanol.

253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Machura; Nawrot; Kruszynski; Dulski; Polyhedron; vol. 54; (2013); p. 272 – 284;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

253-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazine, cas is 253-52-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

A solution of 3.0g (23.3mmol) of phthalazine in 20mL of concentrated sulfuric acid was brought to 100C. To the phthalazine solution was added portion-wise 18.8g (186mmol) of potassium nitrate over 1-h time period. After 72h at 100C, the solution was cooled to room temperature, poured over ice, and neutralized with ammonium hydroxide to produce a yellow-tan precipitate. The precipitate was collected and dried to afford 2.3g (56%) of the 5-nitrophthalazine intermediate as a light yellow solid. 1H NMR (400MHz, DMSO-d6) delta: 10.2 (s, 1 H), 9.98 (s, 1 H), 8.84 (d, J=7.4Hz, 1H), 8.59 (d, J=7.6Hz, 1H), 8.20 (dd, J=7.4, 14.9Hz, 1H). 13C NMR (100.17MHz, DMSO-d6) delta: 152.1, 146.3, 141.0, 133.2, 131.8, 130.0, 127.4, 118.7.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Phthalazine, 253-52-1

Reference£º
Article; Paige, Mikell; Kosturko, George; Bulut, Guellay; Miessau, Matthew; Rahim, Said; Toretsky, Jeffrey A.; Brown, Milton L.; Ueren, Aykut; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 478 – 487;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

253-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazine, cas is 253-52-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a Schlenk tube charged with a stirring bar, the air-stable bidentate Lewis acid catalyst B (5.00 mol percent) and the stated solvent were added under N2. Then, the phthalazine (1.00 equiv), dienophile (2.00 equiv; for enamines, generated in situ from aldehyde and amine) were added subsequently. The reaction mixture was stirred at the given temperature. After the reaction was finished, the solvent was removed. The remaining residue was purified by flash column chromatography over SiO2 to obtain the product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Phthalazine, 253-52-1

Reference£º
Article; Hong, Longcheng; Ahles, Sebastian; Heindl, Andreas H.; Tietcha, Gastelle; Petrov, Andrey; Lu, Zhenpin; Logemann, Christian; Wegner, Hermann A.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 618 – 625;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazine, and cas is 253-52-1, its synthesis route is as follows.

28.1. Preparation of 1-furan-2-yl-1,2-dihydrophthalazine 22.5 ml of an about 1.6M solution of butyllithium are slowly added dropwise at -78¡ã C. to a solution of 2.46 g of furan in 30 ml of tetrahydrofuran. The mixture is stirred at -78¡ã C. for 20 min., then at -20¡ã C. for 2 hrs. The solution is again cooled to -78¡ã C. and treated slowly with a solution of 4.68 g of phthalazine in 36 ml of tetrahydrofuran. The mixture is stirred at -78¡ã C. for 2 hrs., then poured on to about 500 ml of ice-water and extracted 4 times with 150 ml of ethyl acetate each time. The organic phases are dried, concentrated and the residue is chromatographed immediately on 120 g of silica gel; eluent: hexane/ethyl acetate 3:7. 4.08 g of dark, impure 1-furan-2-yl-1,2-dihydrophthalazine are isolated. The following compounds of formula IV are prepared in analogy to Example 28.1.:

253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Hoffmann-La Roche Inc.; US6114330; (2000); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

253-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazine, cas is 253-52-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of tert-butyl acetate(2.67 g, 3.08 mL, 23.0 mmol) in dry THF (40 mL) at ?78 ¡ãC was added dropwise n-butyllithium(2.5 M in hexanes, 7.68 mL, 19.2 mmol) over a period of 30 min. The solution was warmed to ?25 ¡ãCand stirred at this temperature for a period of 30 min. To this reaction mixture was added a solution of1 (2.00 g, 15.4 mmol) in dry THF (25 mL), and stirring was continued for an additional 30 min at 0 ¡ãC.The reaction mixture was poured into saturated NH4Cl (100 mL) and extracted with EtOAc (3 ¡Á 50 mL).The organic extracts were washed with saturated NaCl (50 mL), dried (MgSO4) and concentrated toafford 8 as a light brown oil. The crude product 8 was then dissolved in DCM (50 mL), andtriethylamine (1.86 g, 2.56 mL, 18.4 mmol) was added, followed by dropwise addition of acryloylchloride (1.39 g, 1.25 mL, 15.4 mmol) at 0 ¡ãC. The reaction mixture was stirred at 0 ¡ãC for a period of2 h. The reaction was quenched with saturated NaCl (50 mL), and the organic layer was separated. Theaqueous layer was extracted with DCM (2 ¡Á 50 mL) and the combined organic layers were washedwith saturated NaCl (50 mL), dried (MgSO4), filtered, and concentrated to afford the crude product.The crude product was purified on a silica gel column eluted with hexanes?EtOAc (4:1) to afford 9a(4.00 g, 87percent) as a colorless liquid.

The chemical industry reduces the impact on the environment during synthesis,253-52-1,Phthalazine,I believe this compound will play a more active role in future production and life.

Reference£º
Article; Nammalwar, Baskar; Muddala, N.Prasad; Bourne, Christina R.; Henry, Mary; Bourne, Philip C.; Bunce, Richard A.; Barrow, Esther W.; Berlin, K.Darrell; Barrow, William W.; Molecules; vol. 19; 3; (2014); p. 3231 – 3246;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazine, and cas is 253-52-1, its synthesis route is as follows.

Phthalazinium dicyanomethanide was synthesized by adding phthalazine or phthalazine derivative (14.58 mmol) to a solution of TCNEO (4.86 mmol) in THF (50 mL) at 0 ¡ãC. The reaction was stirred at this temperature for 2 h. Then, the formed solid was isolated by filtration and washed with cold THF (3 * 25 mL) to give the product in nearly quantitative yield.

253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Wang, Bo; Liu, Honglei; Wang, Qijun; Yuan, Chunhao; Jia, Hao; Liu, Chunxiao; Guo, Hongchao; Tetrahedron; vol. 73; 40; (2017); p. 5926 – 5931;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

253-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Phthalazine, cas is 253-52-1,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

3-(2-Bromoacetyl)-2H-chromen-2-one (2.67 g, 10 mmol)and 1.3 g phthalazine (10 mmol) were refluxed understirring in 60 cm3 ethyl acetate for 4 h. The whiteprecipitate formed was removed by filtration and washedwith chloroform on the filter paper to obtain 3d as whitepowder. Yield: 3.771 g (95 percent); m.p.: 244?245 C; 1HNMR (DMSO-d6, 300 MHz): d = 6.60 (s, 2H, CH2),7.49?7.54 (m, 1H, H-Coum), 7.59 (d, J = 8.4 Hz, 1H,H-Coum), 7.86?7.91 (m, 1H, H-Coum), 8.09 (dd, J = 7.7,1.5 Hz, 1H, H-Coum), 8.50?8.55 (m, 1H, H-6), 8.61?8.70(m, 1H, H-7), 8.71 (d, J = 7.7 Hz, 1H, H-5), 8.71 (d,J = 7.9 Hz, 1H, H-8), 8.98 (s, 1H, H-Coum), 10.23 (s, 1H,H-4), 10.76 (s, 1H, H-1) ppm; 13C NMR (DMSO-d6,75 MHz): d = 72.2 (CH2), 117.4 (C-Coum), 126.8 (CCoum),129.6 (Pht), 131.8 (C-Coum), 132.5 (C-Coum),136.8 (Pht), 137.6 (Pht), 140.9 (Pht), 118.9, 122.5, 128.1,128.4, 155.8, 159.6 (C4a, C-8a, 4 Cq-Coum), 150.4 (CCoum),154.4 (C-4), 155.7 (C-1), 186.3 (CO-Coum) ppm.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Phthalazine, 253-52-1

Reference£º
Article; Popa, Marcel M.; Georgescu, Emilian; Draghici, Constantin; Georgescu, Florentina; Dumitrascu, Florea; Dumitrescu, Denisa; Monatshefte fur Chemie; vol. 146; 12; (2015); p. 2029 – 2040;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

Name is Phthalazine, as a common heterocyclic compound, it belongs to phthalazine compound, and cas is 253-52-1, its synthesis route is as follows.

General procedure: A solution of sodium azide (0.085 g, 1.3 mmol) in water (10 ml) was slowly added to the methanolic solution (15 ml) of Cd(NO3)24H2O (0.2 g, 0.65 mmol) and quinazoline (0.17 g, 1.30 mmol) and stirred at room temperature for 12 h. Light yellow crystalline precipitate of [Cd(Qnz)2(N3)2]n was collected in 70percent yield. The crystals suitable for X-ray structure determination were obtained by slow recrystallization from methanol

253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Machura; Nawrot; Kruszynski; Dulski; Polyhedron; vol. 54; (2013); p. 272 – 284;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to phthalazine compound, name is Phthalazine, and cas is 253-52-1, its synthesis route is as follows.

(C) Phthalazine-5,8-dione precursors (Y1 and Y4=C, Y2 and Y3=N) used in the process of the present invention were prepared according to the following reaction scheme 4. The detailed procedure is described in (i) J. Med. Chem., 48, 744-752, and (ii) Bioorganic and Medical Chemistry Letters, 27, 2577-2580.

253-52-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,253-52-1 ,Phthalazine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Gerogetown University; Brown, Milton L.; Paige, Mikell; Torestsky, Jeffrey A.; Uren, Aykut; Kosturko, George; Bulut, Gullay; (58 pag.)US9522908; (2016); B2;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem