Category: 4271-30-1

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Synthetic Route of 4271-30-1, 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, SMILES is O=C(O)[C@@H](NC(C1=CC=C(N)C=C1)=O)CCC(O)=O, in an article , author is Zaib, Sumera, once mentioned of 4271-30-1.

Fused diaza-heterocycles constitute the core structure of numerous bioactive natural products and effective therapeutic drugs. Among them, phthalazines have been recognized as remarkable structural leads in medicinal chemistry due to their wide application in pharmaceutical and agrochemical industries. Accessing such challenging pharmaceutical agents/drug candidates with high chemical complexity through synthetically efficient approaches remains an attractive goal in the contemporary medicinal chemistry and drug discovery arena. In this review, we focus on the recent developments in the synthetic routes towards the generation of phthalazine-based active pharmaceutical ingredients and their biological potential against various targets. The general reaction scope of these innovative and easily accessible strategies was emphasized focusing on the functional group tolerance, substrate and coupling partner compatibility/limitation, the choice of catalyst, and product diversification. These processes were also accompanied by the mechanistic insights where deemed appropriate to demonstrate meaningful information. Moreover, the rapid examination of the structure-activity relationship analyses around the phthalazine core enabled by the pharmacophore replacement/integration revealed the generation of robust, efficient, and more selective compounds with pronounced biological effects. A large variety of in silico methods and ADME profiling tools were also employed to provide a global appraisal of the pharmacokinetics profile of diaza-heterocycles. Thus, the discovery of new structural leads offers the promise of improving treatments for various tropical diseases such as tuberculosis, leishmaniasis, malaria, Chagas disease, among many others including various cancers, atherosclerosis, HIV, inflammatory, and cardiovascular diseases. We hope this review would serve as an informative collection of structurally diverse molecules enabling the generation of mature, high-quality, and innovative routes to support the drug discovery endeavors.

Synthetic Route of 4271-30-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4271-30-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. , Computed Properties of https://www.ambeed.com/products/4271-30-1.html, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, molecular formula is C12H14N2O5, belongs to phthalazine compound. In a document, author is Tayebee, Reza.

A novel Bronsted acidic ionic liquid 3-sulfonic acid 1-imidazolopyridinium hydrogen sulfate [Simp]HSO4 was synthesized via the reaction of caffeine with chlorosulfonic acid and was characterized by studying FT-IR, H-1 NMR, C-13 NMR, UV-Vis, and fluorescence spectra. Then, the prepared ionic liquid was utilized as an efficient catalyst for the preparation of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives through one-pot, multi-component condensation of aldehydes, phthalhydrazide, and dimedone under solvent free conditions. The high Bronsted acidic function of this catalyst originates principally from the dual hydrogen bonding abilities of the SO3H group. (C) 2015 Elsevier B.V. All rights reserved.

Interested yet? Read on for other articles about 4271-30-1, you can contact me at any time and look forward to more communication. Computed Properties of https://www.ambeed.com/products/4271-30-1.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Shaterian, Hamid Reza, once mentioned the application of 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, molecular formula is C12H14N2O5, molecular weight is 266.25, MDL number is MFCD00042821, category is phthalazine. Now introduce a scientific discovery about this category, Safety of (S)-2-(4-Aminobenzamido)pentanedioic acid.

An efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives from the four-component condensation of dimedone, arylaldehyde, hydrazine monohydrate, and phthalic anhydride using reusable ionic liquids, 2-pyrrolidonium hydrogensulfate, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogensulfate and triphenyl(propyl-3-sulphonyl)phosphonium toluenesulfonate as acidic catalysts have been investigated. (C) 2012 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

If you’re interested in learning more about 4271-30-1. The above is the message from the blog manager. Safety of (S)-2-(4-Aminobenzamido)pentanedioic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4271-30-1, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, SMILES is O=C(O)[C@@H](NC(C1=CC=C(N)C=C1)=O)CCC(O)=O, belongs to phthalazine compound. In a article, author is Popovici, Lacramioara, introduce new discover of the category.

Two new series of heterocyclic derivatives with potential anticancer activity, in which a pyrrolo[1,2-b]pyridazine or a pyrrolo[2,1-a]phthalazine moiety was introduced in place of the 3 ‘-hydroxy-4 ‘-methoxyphenyl ring of phenstatin have been synthesised and their structure-activity relationship (SAR) was studied. Fourteen of the new compounds were evaluated for their in vitro cytotoxic activity by National Cancer Institute (NCI) against 60 human tumour cell lines panel. The best five compounds in terms of in vitro growth inhibition were screened in the second stage five dose-response studies, three of them showing a very good antiproliferative activity with GI(50)<100 nM on several cell lines including colon, ovarian, renal, prostate, brain and breast cancer, melanoma and leukemia. Docking experiments on the biologically active compounds showed a good compatibility with the colchicine binding site of tubulin. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4271-30-1, in my other articles. Recommanded Product: 4271-30-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: https://www.ambeed.com/products/4271-30-1.html, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, molecular formula is C12H14N2O5. In an article, author is Zare, Abdolkarim,once mentioned of 4271-30-1.

A novel BrOnsted acidic ionic liquid namely N,N-diethyl-N-sulfoethanamminium hydrogen sulfate ([Et3N-SO3H]HSO4) was synthesized, and characterized using FT-IR, H-1 NMR, C-13 NMR, and mass data. Then, its catalytic activity was examined for the preparation of triazolo[1,2-a]-indazole-triones and 2H-indazolo[2,1-b]phthalazine-triones by the one-pot multi-component condensation of arylaldehydes with dimedone and 4-phenylurazole/2,3-dihydrophthalazine-1,4-dione under solvent-free conditions. [Et3N-SO3H]HSO4 efficiently promoted the reaction to afford the products in high yields and in short reaction times.

If you’re interested in learning more about 4271-30-1. The above is the message from the blog manager. COA of Formula: https://www.ambeed.com/products/4271-30-1.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, molecular formula is C12H14N2O5, belongs to phthalazine compound. In a document, author is Milenkovic, Milica, introduce the new discover, Category: phthalazines.

A square-pyramidal Ni(II) complex (1) with the composition [NiL(HL’)]CIO4 center dot H2O was synthesized in the reaction of nickel(II) perchlorate and 2[2-(diphenylphosphino)benzylidene]-1-phthalazinylhydrazone (HL). The coordination surrounding the Ni(II) ion consist of a PNN coordinated deprotonated HL ligand and its corresponding oxidation product phosphine oxide HL’ coordinated via two nitrogen atoms of the hydrazinophthalazine moiety. The structure of Ni(II) complex 1 was determined by X-ray analysis, IR spectroscopy, elemental analysis and magnetic measurements. In the reaction of copper(II) perchlorate with HL, a binuclear phthalazine bridged Cu(I) complex (2) was obtained with the composition [Cu-2(HL)(2)](ClO4)(2)center dot C2H5OH. The structure of Cu(I) complex 2 was determined by X-ray analysis, IR and NMR spectroscopy, elethental analysis and magnetic measurements. (C) 2016 Elsevier Ltd. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4271-30-1. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 4271-30-1, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, SMILES is O=C(O)[C@@H](NC(C1=CC=C(N)C=C1)=O)CCC(O)=O, belongs to phthalazine compound. In a article, author is Hameed, Alhamzah Dh., introduce new discover of the category.

The chemistry of phthalazine derivatives has been of increasing interest since many of these compounds have found many chemotherapeutic applications. So this study aims to synthesize a library of phthalazine derivatives and to investigate their anti-inflammatory and anti-proliferative activities. Sixteen new phthalazinone derivatives (2a-p) were synthesized and tested for their in vitro antiproliferative and in vivo anti-inflammatory activities. All the synthesized compounds were identified and characterized by IR, H-1 NMR, C-13 NMR spectroscopy, and MS. Two compounds, 2b and 2i, showed significant anti-inflammatory activity comparable with that of the standard drug etoricoxib in the carrageenan-induced rat paw edema model at 3 and 5h, respectively. Three compounds (2h, 2j, and 2g) showed moderate sensitivity toward the renal cancer cell line UO-31.

Synthetic Route of 4271-30-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 4271-30-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 4271-30-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, SMILES is O=C(O)[C@@H](NC(C1=CC=C(N)C=C1)=O)CCC(O)=O, belongs to phthalazine compound. In a article, author is Mayakrishnan, Sivakalai, introduce new discover of the category.

Rhodium catalysed dehydrogenative C-H/N-H functionalization was developed to construct phthalazino[2,3-a]-/indazolo[1,2-a]cinnolines by reacting N-phenyl phthalazine/indazole with alkynes. The synthesized compounds exhibit prominent fluorescence properties in solid and aggregation states. Their application in cell imaging was investigated using various cancer cell lines.

Electric Literature of 4271-30-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 4271-30-1 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, molecular formula is C12H14N2O5, belongs to phthalazine compound, is a common compound. In a patnet, author is Zhou, Jiadi, once mentioned the new application about 4271-30-1, Recommanded Product: 4271-30-1.

An efficient silver-catalyzed d-regioselective C(sp(3))-H heteroarylation of free alcohols has been developed. Various alcohols reacted with quinolines, isoquinoline, pyridines, pyrimidine, phthalazine, 4-hydroxyquinazoline, acridine, quinoxaline and pyrazine to give the corresponding C(sp(2))-H alkylation products in 31-89% yields. Notably, all types (1 degrees, 2 degrees, and 3 degrees) of d-C(sp(3))-H bonds in the alcohols could be regioselectively activated. This protocol provides a platform to access divergent functionalizations of alcohols and heteroaryls by forming the challenging d-selective C(sp(3))-C(sp(2)) bond.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4271-30-1. The above is the message from the blog manager. Recommanded Product: 4271-30-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Quality Control of (S)-2-(4-Aminobenzamido)pentanedioic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 4271-30-1, Name is (S)-2-(4-Aminobenzamido)pentanedioic acid, molecular formula is C12H14N2O5, belongs to phthalazine compound. In a document, author is Reddy, Y. Dathu.

One-pot, four component syntheses for the preparation of 1-H Pyrazolo[1,2-b]phthalazine-5,10-diones (5a-5h) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13-H)-triones (7a-7f) have been described from phthaloyl dichloride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a), ethyl cynoacetate (4b) or dimedone (6) in refluxing water for 1-1.5 h by in-situ generation of HCl as a catalyst. These reactions have easy workup, provide excellent yields, and use water as the solvent.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4271-30-1. Quality Control of (S)-2-(4-Aminobenzamido)pentanedioic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem