Category: 502496-34-6

Reference of 502496-34-6, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a article, author is Fallah-Ghasemi Gildeh, Sara, introduce new discover of the category.

Benzylation of DBU followed by anion exchange of the resulting salt with trifluoroacetate gave nearly quantitatively the ionic liquid [Bn-DBU][TFA]. It is shown here to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dionesviathe three-component reaction of phthalhydrazide, aromatic aldehydes, and active alpha-methylene nitriles. DFT calculations at the B3LYP/SVP level and the experimental results are in agreement with a three-step mechanism for this reaction. Based on the DFT calculations, the catalytic effect largely arises from the intrinsic ionic properties of the ionic liquid rather than its action as a simple base. These calculations also predict the existence of two close-in-energy activated complexes whose rate determining roles and energies depend on their interaction with the anionic component of the ionic liquid, as [Bn-DBU][TFA] has shown a higher catalytic activity than [Bn-DBU][OAc]. This mechanistic approach opens up new and promising insights into the rational design of ionic liquid catalysts for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones. The synthetic method presented here has several prominent advantages.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a document, author is Piltan, Mohammad, introduce the new discover, SDS of cas: 502496-34-6.

Zirconium oxide nanoparticles are an efficient catalyst for the preparation of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones via a three-component reaction of phthalhydrazide, aromatic aldehydes and malononitrile under solvent-free conditions.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Healthcare careers for chemists are once again largely based in laboratories, COA of Formula: https://www.ambeed.com/products/502496-34-6.html, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a document, author is Veisi, Hojat, introduce the new discover.

The mildly basic ionic liquid N,N,N,N-tetramethylguanidinium acetate [TMG][Ac] was found to be a very effective basic catalyst for the one-pot, four-component synthesis of 2H-indazolo[2,1-b] phthalazinetriones by condensation of phthalic anhydride, hydrazinium hydroxide, aromatic aldehydes, and dimedone in high yields at 80 degrees C. [TMG][Ac] catalyzed simple and efficient one-pot four-component reaction of Meldrums acid, ethyl acetoacetate, hydrazine hydrate, and aromatic aldehydes to give dihydro-1H-pyrano[2,3-c] pyrazol-6-ones is reported. The ionic liquid could be recycled several times without loss of efficiency with regards to the reaction times and yields.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a document, author is Levchenkov, S. I., introduce the new discover, Computed Properties of https://www.ambeed.com/products/502496-34-6.html.

Binuclear complexes of copper(II) with 1′-phthalazinylhydrazones of substituted salicylic aldehydes have been prepared and studied. Antiferromagnetic exchange interaction between copper(II) ions has been revealed in all the complexes. Taking advantage of quantum-chemical simulation, we have investigated the influence of the complexes structural isomerism on the character of the exchange interaction between the paramagnetic centers. X-ray absorbance spectroscopy afforded the structural parameters of coordination spheres of copper(II) ions; it has been demonstrated that dimerization occurred via the nitrogen atoms of phthalazine fragments.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. Application In Synthesis of 4-Bromo-2-fluoro-6-nitrotoluene, 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, in an article , author is Berber, Nurcan, once mentioned of 502496-34-6.

A new series of phthalazine substituted beta-lactam derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and the nitro group was reduced to 13-(4-aminophenyl)-3,3-dimethyl-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione with SnCl2 center dot 2H(2)O. The reduced compound was reacted with different aromatic aldehydes, and phthalazine substituted imines were synthesized. The imine compounds undergo (2+2) cycloaddition reactions with ketenes to produce 2H-indazolo[2,1-b]phthalazine-trione substituted beta-lactam derivatives. The beta-lactam compounds were tested as inhibitors of the CA isoenzyme activity. The results showed that all the synthesized compounds inhibited the CA isoenzyme activity. 1-(4-(3,3-dimethyl-1,6,11-trioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b]phthalazin-13-yl)phenyl)-2-oxo-4-p-tolylazetidin-3-yl acetate (IC50 = 6.97 A mu M for hCA I and 8.48 A mu M for hCA II) had the most inhibitory effect.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Name: 4-Bromo-2-fluoro-6-nitrotoluene, 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, in an article , author is Wei, Cheng-Xi, once mentioned of 502496-34-6.

In a previous research, we synthesized and evaluated the anticonvulsant activity of a series of 6-substituted-oxy-[1,2,4] triazolo[3,4-a] phthalazine compounds. Reference to other studies, we deduce that the compounds may be useful for regulating inotropic activity by effecting stroke volume, so in this study, we evaluated 20 compounds (15a-t) for their changed inotropic activity by measuring the left atrium stroke volume in heart preparations isolated from Wistar rats. Among the 20 compounds, 15j was the most potent with an increased stroke volume of 27.39 +/- 3.16 % at the concentration of 50 mu M, compound 15m was identified as the most potent with an decreased stroke volume of -95.59 +/- 0.50 % at the same concentration which is much more effective than referenced drug Nifedipine (-55.22 +/- 1.87% at the concentration of 1 mu M).

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, molecular formula is C7H5BrFNO2, Reference of 502496-34-6, belongs to phthalazine compound, is a common compound. In a patnet, author is Amirmahani, Najmeh, once mentioned the new application about 502496-34-6.

Tetrabutyl phosphonium sulfate ([TBP](2)SO4), as novel room-temperature ionic liquid (RTIL), was synthesized by a simple cost-effective method, characterized by H-1, C-13, P-31 NMR and FT-IR spectrophotometry. The newly prepared catalyst was used as an efficient catalyst in some four multicomponent reactions (4MCRs) e. g., to synthesis pyridazino[1,2-a]indazole, indazolo[2,1-b]phthalazine and pyrazolo[1,2-b]phthalazine. This green method has several advantages such as short reaction time, using simple methods to prepare catalysts and products, easy operation and high efficiency of products. In addition, the catalyst can be easily recovered and reused several times with reduced average activity. Graphic abstract

Synthetic Route of 502496-34-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 502496-34-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 4-Bromo-2-fluoro-6-nitrotoluene, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a article, author is Shaterian, Hamid Reza, introduce new discover of the category.

A practical and green method for the synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives using cellulose-SO3H as a solid acidic catalyst for the four-component condensation reaction of hydrazinium hydroxide, phthalic anhydride, dimedone, and aromatic aldehydes under thermal solvent-free conditions is described. Cellulose-SO3H as a recyclable green chemical compound has been demonstrated as a new catalyst for the synthesis of this class of compounds.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: https://www.ambeed.com/products/502496-34-6.html, We’ll be discussing some of the latest developments in chemical about CAS: 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a article, author is Taslimi, Parham, introduce new discover of the category.

In this study, using the Cu(OTf)(2) catalyst, 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivative molecules were carried out in one step and with high yield (86-91%). The previously synthesized 1H-pyrazolo [1,2-b]phthalazine-5,10-dione derivatives, carbonic anhydrase I and II isozymes (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and alpha-glycosidase (alpha-Gly) enzymes with K-i values in the range of 4.88-15.94 nM for hCA I, 7.04-20.83 nM for hCA II, 68.25-158.27 for AChE, 60.17-91.27 for BChE and 0.36-2.36 nM for alpha-Gly, respectively. In silico studies were performed on the molecules inhibiting hCA I, hCA II, AChE, BChE and alpha-Gly receptors. When we evaluated the data obtained in this work, we determined the inhibition type of the 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives at the receptors. Reference inhibitors were used for all enzymes.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 502496-34-6, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a article, author is Nikoorazm, Mohsen, introduce new discover of the category.

A simple and efficient protocol has been developed for the synthesis and characterization of new Cu(II) complex supported into MCM-41 channels modified with adenine (Cu(II)-Adenine-MCM-41) as a reusable and heterogeneous catalyst for the synthesis of 5-substituted 1H-tetrazoles and 1H-indazolo [1,2-b]phthalazine-triones. The key advantages of this method are easy work-up, short reaction times, pure product formation with good to excellent yields and reusability of the catalyst. This catalyst was characterized by TEM, SEM, XRD, TGA, EDS, AAS, BET method and FT-IR spectroscopy.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem