Category: 523-27-3

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 523-27-3, Name is 9,10-Dibromoanthracene, SMILES is BrC1=C2C=CC=CC2=C(Br)C3=CC=CC=C13, in an article , author is Elmeligie, Salwa, once mentioned of 523-27-3, Quality Control of 9,10-Dibromoanthracene.

Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (6b, 6e, 7b, 13a, 13c, 16a, 16d and 17a) exhibited excellent broad spectrum cytotoxic activity in NCI 5-log dose assays against the full 60 cell panel with GI(50) values ranging from 0.15 to 8.41 mu M. Moreover, the enzymatic assessment of the synthesised compounds against VEGFR-2 tyrosine kinase showed the significant inhibitory activities of the biarylureas (12b, 12c and 13c) with IC(50)s of 4.4, 2.7 and 2.5 mu M, respectively, and with 79.83, 72.58 and 71.6% inhibition of HUVEC at 10 mu M, respectively. Additionally, compounds (7b, 13c and 16a) were found to induce cell cycle arrest at S phase boundary. Compound 7b triggered a concurrent increase in cleaved caspase-3 expression level, indicating the apoptotic-induced cell death.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 523-27-3, you can contact me at any time and look forward to more communication. Quality Control of 9,10-Dibromoanthracene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 523-27-3, Name is 9,10-Dibromoanthracene, molecular formula is C14H8Br2, belongs to phthalazines compound. In a document, author is Chen, Hui, introduce the new discover, Formula: C14H8Br2.

Efficient One-Pot Synthesis of Spiro[indoline-3,1 ‘-pyrazolo[1,2-b] phthalazine] Derivatives via Three-Component Reaction

An efficient one-pot synthesis of spiro[indoline-3,1’-pyrazolo[1,2-b]phthalazine] derivatives via three-component reaction of phthalhydrazide, isatin, and malononitrile (cyanoacetic ester) is described. This new protocol has the advantages of high efficiency, mild reaction conditions, one-pot procedure, and convenient operation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 523-27-3. Formula: C14H8Br2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 523-27-3, Name is 9,10-Dibromoanthracene, SMILES is BrC1=C2C=CC=CC2=C(Br)C3=CC=CC=C13, in an article , author is Ibrahim, Hany S., once mentioned of 523-27-3, Recommanded Product: 9,10-Dibromoanthracene.

Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds

RAB1 5 is a lead antibacterial agent in which trimethoprim is linked to phthalazine moiety. Similarly, our strategy in this research depends on the interconnection between some sulfa drugs and certain phthalazin-1(2H)-one scaffolds in an attempt to enhance their antibacterial activity. This approach was achieved through the combination of 4-substituted phthalazin-1(2H)-ones 9a, b or 14a, b with sulfanilamide 1a, sulfathiazole 1b or sulfadiazine 1c through amide linkers 6a, b to produce the target compounds 10a-d and 15a-e, respectively. The antibacterial activity of the newly synthesized compounds showed that all tested compounds have antibacterial activity higher than that of their reference sulfa drugs 1a-c. Compound 10c represented the highest antibacterial activity against Gram-positive bacteria Streptococcus pneumonia and Staphylococcus aureus with MIC = 0.39 mu mol/mL. Moreover, compound 10d displayed excellent antibacterial activity against Gram-negative bacteria Escherichia coli and Salmonella Lyphimurium with MIC = 0.39 and 0.78 mu mol/mL, respectively. (C) 2014 Elsevier Masson SAS. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 523-27-3, you can contact me at any time and look forward to more communication. Recommanded Product: 9,10-Dibromoanthracene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 523-27-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 523-27-3, Name is 9,10-Dibromoanthracene, SMILES is BrC1=C2C=CC=CC2=C(Br)C3=CC=CC=C13, belongs to phthalazines compound. In a article, author is Yuan, Chunhao, introduce new discover of the category.

Phosphine-catalyzed [3+2] cycloaddition of phthalazinium dicyanomethanides with allenoates: highly efficient synthesis of 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives

The phosphine-catalyzed [3 + 2] cycloaddition between phthalazinium dicyanomethanides and allenoates, has been achieved in dichloromethane at room temperature, providing a broad range of novel heterocyclic compounds, 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives, as single (Z)-isomers in excellent yields (88-99% yield). All reactions are operationally simple and proceed very fast under mild reaction conditions.

Synthetic Route of 523-27-3, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 523-27-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 523-27-3, Name is 9,10-Dibromoanthracene, formurla is C14H8Br2. In a document, author is Xin, Lijun, introducing its new discovery. Application In Synthesis of 9,10-Dibromoanthracene.

Efficient near-infrared-emitting cationic iridium complexes based on highly conjugated cyclometalated benzo[g]phthalazine derivatives

Two near-infrared-(NIR-) emitting cationic iridium(III) complexes, [Ir(dpbpa)(2)(Bphen)]+PF6- (1) and [Ir(dtbpa)(2)(Bphen)]+PF6- (2), were rationally designed and synthesized, where dpbpa, dtbpa, and Bphen represent 1,4-diphenylbenzo[g]-phthalazine, 1,4-di(thiophen-2-yl)benzo[g]phthalazine and 4,7-dipheny1,10-phenanthroline, respectively. By using highly conjugated cyclometalated benzo[g]phthalazine ligands, these two complexes exhibited a significantly large red shift in wavelength to the truly NIR region with maximum peaks at 715 nm for 1 and 775 nm for 2. Complex 1 exhibited unexpectedly improved quantum efficiency up to 6.1% in the solid films. Based on these solution-processable phosphors, NIR organic-light-emitting devices (OLEDs) have been fabricated and demonstrated negligible efficiency roll-off with nearly constant external quantum efficiency around 0.5% over a wide range of current density of 1-100 mA cm(-2). Density functional theory calculations were performed to discover that the newly cyclometalated benzo[g]phthalazine ligands have several areas of superiority over the previous benzo[g]quinoline ligands in views of stronger Ir-N bonds, smaller chelate congestion, higher electron-accepting ability, thus improving the overall phosphorescence of the corresponding iridium complexes in the NIR region.

If you are hungry for even more, make sure to check my other article about 523-27-3, Application In Synthesis of 9,10-Dibromoanthracene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

523-27-3, Name is 9,10-Dibromoanthracene, molecular formula is C14H8Br2, belongs to phthalazines compound, is a common compound. In a patnet, author is Wang, Shi-Ben, once mentioned the new application about 523-27-3, Application In Synthesis of 9,10-Dibromoanthracene.

Synthesis and Anticonvulsant Activity Evaluation of Some 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazines

A series of 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazine derivatives were synthesized using 2,3-dihydrophthalazine-1,4-dione as starting material. The structures of the compounds were characterized by elemental analysis, IR, H-1-NMR and MS data. Anticonvulsant activities of these compounds were evaluated by maximal electroshock (MES) test following intraperitoneal injection in mice. Among the synthesized compounds 3a-3t, compound 3e was the most active compound with an ED50 of 28.9 mg/kg, TD50 of 173.6 mg/kg and protective index (PI) of 6.0.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 523-27-3, Name is 9,10-Dibromoanthracene, molecular formula is C14H8Br2, belongs to phthalazines compound. In a document, author is Hamidinasab, Mahdia, introduce the new discover, Quality Control of 9,10-Dibromoanthracene.

Green one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones: a comparative study of heterogeneous solid acid catalysts with magnetic core

The catalytic activity of four heterogeneous solid acid catalysts with magnetic core and sulfonic acid groups is evaluated and compared using one-pot three component synthesis of phthalazine-trione derivatives under solvent-free condition. The NiFe2O4 particles were selected as magnetic core, due to their enhanced chemical and magnetic stability. Furthermore, the desired products were obtained in excellent yields at short reaction times and environmentally friendly condition using the novel and reusable sulfonic acid grafted onto TiO2-coated nickel ferrite nanoparticles. This protocol avoids the use of expensive catalysts, toxic solvents and harsh reaction conditions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 523-27-3. Quality Control of 9,10-Dibromoanthracene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 523-27-3, Name is 9,10-Dibromoanthracene, molecular formula is C14H8Br2, belongs to phthalazines compound. In a document, author is Chacko, Priya, introduce the new discover, Recommanded Product: 9,10-Dibromoanthracene.

Nano Structured Bi2O3 Catalyzed Synthesis of 3-Phenyl-[1,2,4]Triazolo[3,4-a]Phthalazines and Their Cross-coupling Reaction Under Aqueous Conditions

A novel and an expeditious approach for the synthesis of 3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine derivatives has been achieved from 1,4-dichlorophthlazine and benzohydrazides in the presence of nano Bi2O3 catalyst. 3-Phenyl-[1,2,4]triazolo[3,4-a]phthalazines undergo substitution reaction with various -OH group to produce 6-substituted-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazines in excellent yields under aqueous condition in the presence of Pd(OAc)(2), BINAP and nano Bi2O3 catalyst. The present protocol tolerates various functional groups and represents a reliable and time efficient method.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 523-27-3. Recommanded Product: 9,10-Dibromoanthracene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem