Category: 587-04-2

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 587-04-2, 587-04-2, Name is 3-Chlorobenzaldehyde, molecular formula is C7H5ClO, belongs to phthalazine compound. In a document, author is Yu, Li-Jun, introduce the new discover.

In a previous research, we found a compound named 6-(3-(trifluoromethyl)-benzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine (BM-1) much more effective in the maximal electroshock (MES) model for mouse and much safer in the neurotoxicity (NT) screening, which indicated that it may be used as antiepileptic drug. But, those evaluations were too rough. So in this study, we did more work to assess the anticonvulsant activity and the toxicity about BM-1. The peak times of protection of BM-1 after intraperitoneal injection (ip) and oral administration (po) were determined using the MES test, and the anticonvulsant activity of it was compared with the reference drug, carbamazepine, at these peak times. The rotarod test was applied to measure its neurotoxicity. When compared with the reference drug in the maximal electroshock (MES) test at the time to peak effect, it showed that BM-1 was much more effective and safer than reference drug Carbamazepine with ED50 of 11.2 mg/kg, TD50 of 72.2 mg/kg and PI of 6.5 after administration of ip, while when administered orally, that values of ED50, TD50 and PI of BM-1-1, BM-1-2 and BM-1-3 were much better than Carbamazepine and BM-1 after po. The compound BM-1 has more effective anticonvulsant activity and lower neurotoxicity administered by both ip and po. So BM-1 could may be used instead of the prescribed antiepileptic drugs (AEDs) in the future.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 587-04-2. SDS of cas: 587-04-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Computed Properties of https://www.ambeed.com/products/587-04-2.html, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 587-04-2, Name is 3-Chlorobenzaldehyde, molecular formula is C7H5ClO, belongs to phthalazine compound. In a document, author is Behalo, Mohamed S..

A new series of phthalazine derivatives was synthesized from the reaction of 1-chloro-4-(4-phenoxyphenyl)phthalazine as a reactive starting material with different carbon, nitrogen, oxygen, and sulfur nucleophiles. The structural formulae of all products were confirmed and characterized by elemental analyses and spectral data (IR, H-1 NMR, C-13 NMR, and mass spectra). Some of the synthesized derivatives were screened for their antitumor activity against four human tumor cell lines using MTT assay. In comparison with doxorubicin as standard drug, compounds 1, 20, and 25 showed the most potent cytotoxic effect. In addition, investigation of antioxidant activity revealed that hydrazinylphthalazine 20 has the highest activity.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 587-04-2. Computed Properties of https://www.ambeed.com/products/587-04-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 587-04-2, Name is 3-Chlorobenzaldehyde, SMILES is O=CC1=CC=CC(Cl)=C1, belongs to phthalazine compound. In a document, author is Song, Shi-Hua, introduce the new discover, COA of Formula: https://www.ambeed.com/products/587-04-2.html.

The synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives by NiCl2-catalyzed novel one-pot four-component condensation reaction of phthalimide, hydrazine, malononitrile (or ethyl cyanoacetate), and aromatic aldehydes was reported. This work provides a simple, efficient, and eco-friendly method for the construction of pyrazolo[1,2-b]phalazine-5,10-dione derivatives. (C) 2012 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 587-04-2 is helpful to your research. COA of Formula: https://www.ambeed.com/products/587-04-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 587-04-2, Name is 3-Chlorobenzaldehyde, SMILES is O=CC1=CC=CC(Cl)=C1, belongs to phthalazine compound. In a document, author is Nagella, Praveen, introduce the new discover, Computed Properties of https://www.ambeed.com/products/587-04-2.html.

The leaves of Apium graveolens were extracted and the essential oil composition, immunotoxicity effects, and antioxidant activity were studied. The analyses were conducted by gas chromatography and mass spectroscopy (GC-MS), which revealed the essential oils of A. graveolens leaves. Twenty-eight components, representing 73.72% of the total oil were identified from the leaves. The major components are 4-chloro-4,4-dimethyl-3-(1-imidazolyl)-valerophenone (19.90%), 1-dodecanol (16.55%), 9-octadecen-12-ynoic acid, methyl ester (4.93%), ethyl 4,4-D2-N-hexyl ether (4.11%), 3-(hydroxymethyl)-1-phenyl-1-heptadecyn-3-ol (3.28%), 1,4-methano-1H-indene, octahydro-4-methyl-8-methylene-7-(1-methylethyl)-, [1S-(1 alpha,3 alpha alpha,4 alpha,7 alpha,7 alpha alpha)]- (2.99%), 3,4-dihydro-2H-1,5-(3 ”-t-butyl) benzodioxepine (2.56%), Z-10-tetradecen-1-ol acetate (2.53%), 9H-pyrrolo[3′,4′:3,4] pyrrolo[2,1-alpha]phthalazine-9, 11(10H)-dione, 10-ethyl-8-phenyl (2.07%). The leaf oil had significant toxic effects against the larvae of A. aegypti with an LC50 value of 59.32 ppm and an LC90 value of 127.69 ppm. The essential oil from the A. graveolens leaves was investigated for scavenging of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical activity and the results demonstrate that the essential oil from the A. graveolens has potential as a natural antioxidant and thus inhibit unwanted oxidation process. The above data indicate that the major compounds may play an important role in the toxicity of essential oils and also as natural antioxidant.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 587-04-2 is helpful to your research. Computed Properties of https://www.ambeed.com/products/587-04-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.587-04-2, Name is 3-Chlorobenzaldehyde, SMILES is O=CC1=CC=CC(Cl)=C1, belongs to phthalazine compound. In a document, author is Ziarani, Ghodsi Mohammadi, introduce the new discover, Product Details of 587-04-2.

SULFONIC ACID FUNCTIONALIZED NANOPOROUS SILICA (SBA-PR-SO3H) AS AN EFFICIENT CATALYST FOR THE ONE-POT SYNTHESIS OF 2H-INDAZOLO[1,2-B] PHTHALAZINE-TRIONES

Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) with a pore size of 6 nm is an efficient catalyst in the green three-component condensation of phthalhydrazide, dimedone and aldehydes to give 2H-indazolo[1,2-b] phthalazine-triones under solvent-free conditions in excellent yields and short reaction times.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 587-04-2. Product Details of 587-04-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 587-04-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 587-04-2, Name is 3-Chlorobenzaldehyde, SMILES is O=CC1=CC=CC(Cl)=C1, belongs to phthalazine compound. In a article, author is Abouzid, Khaled A. M., introduce new discover of the category.

4-Substitutedphthalazines and phthalazinones: synthesis, characterization and beta-adrenergic blocking activity

Novel 4-(4-bromophenyl)phthalazine and phthalazinone derivatives connected through 2-propanol spacer to N-substituted piperazine residue were synthesized. All the new compounds were screened for their effect on beta-adrenergic blocking activity on the norepinephrine-induced precontracted aortic ring module. Most test compounds displayed appreciable beta-adrenolytic activity compared to propranolol as a reference standard. The results have shown that compounds 3a, 3d, 3e and 7c displayed appreciable inhibition of norepinephrine-induced aortic ring contraction. A novel 4-(4-bromophenyl)phthalazine and phthalazinone derivatives connected through 2-propanol spacer to N-substituted piperazine residue were synthesized. All new compounds were screened for their effect on beta-adrenergic blocking activity on the norepinephrine-induced precontracted aortic ring module.

Synthetic Route of 587-04-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 587-04-2 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 587-04-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 587-04-2, Name is 3-Chlorobenzaldehyde, SMILES is O=CC1=CC=CC(Cl)=C1, belongs to phthalazine compound. In a article, author is Kashanna, Jajula, introduce new discover of the category.

2,3-Dihydrofurans as Potential Cytotoxic and Antibacterial Agents: Tandem Knoevenagel-Michael Cyclization for the Synthesis of 2,3-Dihydrofurans by Using alpha-Tosyloxy Ketone Precursors

Novel 2,3-dihydrofuran derivatives were synthesized through a tandem Knoevenagel-Michael cyclization in good yield by reacting alpha-tosyloxy ketone, 5,5-dimethyl-1,3-cyclohexanedione, and various aldehydes in the presence of phthalazine in acetonitrile. These compounds were subjected to in vitro antibacterial screening against eight micro-organisms by using diffusion method and also in vitro cytotoxicity screening against four human cancerous cell lines by applying MTT assay. Some of the compounds showed impressive activities.

Application of 587-04-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 587-04-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 3-Chlorobenzaldehyde587-04-2, Name is 3-Chlorobenzaldehyde, SMILES is O=CC1=CC=CC(Cl)=C1, belongs to phthalazine compound. In a article, author is Zhu, Jie, introduce new discover of the category.

Enantioselective Dihydroxylation of Alkenes Catalyzed by 1,4-Bis(9-O-dihydroquinidinyl)phthalazine-Modified Binaphthyl-Osmium Nanoparticles

A series of unprecedented binaphthyl-osmium nanoparticles (OsNPs) with chiral modifiers were applied in the heterogeneous asymmetric dihydroxylation of alkenes. A remarkable size effect of the OsNPs, depending on the density of the covalent organic shells, on the reactivity and enantioselectivity of the dihydroxylation reaction was revealed. Successful recycling of the OsNPs was also demonstrated and high reaction efficiency and enantioselectivity were maintained.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 587-04-2. Recommanded Product: 3-Chlorobenzaldehyde.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 587-04-2, Name is 3-Chlorobenzaldehyde, molecular formula is C7H5ClO, belongs to phthalazine compound. In a document, author is Yu, Hai-Ling, introduce the new discover, Category: phthalazines.

Anti-inflammatory and antinociceptive effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine in mice

Background: QUAN-0808 (6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine), a new phthalazine tetrazole derivative, was evaluated for the anti-inflammatory and analgesic effects. Methods: Xylene-induced ear edema, carrageenan (Carr)-induced paw edema, and acetic acid-induced capillary permeability hyperactivity in mice were used to assess the anti-inflammatory effect; acetic acid-induced writhing and hot plate responses for the analgesic activity. Results: In the present study, QUAN-0808 (100, 200, 400 mg/kg) and indomethacin (Indo) significantly decreased xylene-induced ear edema by 33.3, 37.5, 46.6, and 45.1%, respectively, decreased Carr-induced paw edema at 1, 2, 4 h after Carr injection, and decreased the prostaglandin E-2 (PGE(2)) and nitric oxide (NO) levels on the edema paw at 4 h after Carr injection; QUAN-0808 (100, 200,400 mg/kg), and aspirin (Asp, 200 mg/kg) significantly decreased Evans blue exudation in acetic acid-induced capillary permeability hyperactivity model by 26.7, 28.7, 32.3 and 29.1%, respectively, and decreased the numbers of acetic acid-induced writhing response in 15 min by 40.4, 53.6, 66.4, and 64.5%, respectively. Morphine (10 mg/kg) significantly increased the latency of the hot plate response by 136.5, 117.4, 67.5, and 22.7%, respectively, at 30, 60, 90, 120 min after intraperitoneal injection of morphine; however, QUAN-0808 (100, 200 and 400 mg/kg) did not produce significantly antinociceptive effects in the hot plate test, suggesting that its antinociceptive action occurs via peripheral rather than a central-acting mechanism. Conclusions: These results show that QUAN-0808 produced potential anti-inflammatory and peripheral antinociceptive effects, and indicated that the antinociceptive effects of QUAN-0808 were related to its anti-inflammatory activity in a dose-dependent manner. Therefore, as inflammation is a peripheral process, it is suggested that QUAN-0808 exerted peripheral effects. The peripheral effect mechanisms of QUAN-0808 may be related to a decrease in the production of PGR(2), NO, bradykinin and other inflammatory mediators.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 587-04-2. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, HPLC of Formula: C7H5ClO, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 587-04-2, Name is 3-Chlorobenzaldehyde, molecular formula is C7H5ClO, belongs to phthalazine compound. In a document, author is Wang, Liang.

Bronsted acidic deep eutectic solvent catalysed the one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones

An efficient and facile protocol for the one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones in the presence of a Bronsted acidic deep eutectic solvent has been developed. The Bronsted acidic deep eutectic solvent was readily prepared via heating the mixture of choline chloride and p-toluenesulfonic acid. In addition, the deep eutectic solvent is non-toxic, cost-effective and recyclable.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 587-04-2, in my other articles. HPLC of Formula: C7H5ClO.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem