Category: 58743-75-2

Recommanded Product: 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, SMILES is N#CC1=CC=C(C2=CC=C(CC)C=C2)C=C1, belongs to phthalazine compound. In a article, author is Turhan, K., introduce new discover of the category.

In this study, substituted 2H-indazolo[2,1-b]phthalazine-1,6,11-triones, that may possess biological activity, have been synthesized via one-pot three-component cyclocondensation reaction of aromatic aldehydes, cyclic 1,3-dione and phthalhydrazide in ethanol catalyzed by Y(OTf)(3) with good to excellent yields. The structures of all synthesized compounds, 3,4-dihydro-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4a), 13-(4-cyanophenyl)-3,4-dihydro-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4b), 3,4-dihydro-3,3-dimethyl-13-(4-cyanophenyl)-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4c), 3,4-dihydro-3,3-dimethyl-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4d), and 3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4e) have been elucidated from IR, NMR and mass spectral data.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, SMILES is N#CC1=CC=C(C2=CC=C(CC)C=C2)C=C1, belongs to phthalazine compound. In a article, author is Yu, Hai-Ling, introduce new discover of the category.

Thrombosis is a major complication that could be fatal in acute or chronic cardio-cerebral-vascular diseases. Therefore, the development of novel agents for anticlotting and the prevention of thrombosis and cardiovascular diseases are clinically significant. This study aimed to evaluate the anticoagulant and antithrombotic effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine (Q808), a new phthalazine tetrazole derivative. Bleeding time, clotting time, and serum calcium ion (Ca2+) concentration were assessed in mice, whereas arteriovenous thrombus weight and plasma prothrombin time were evaluated in rats, and platelets Ca2+ influx was determined in rabbit. Daily oral administration of Q808 at 25, 50, or 100 mg/kg for 3 days significantly delayed bleeding time and clotting time in mice compared with controls. Q808 administration at 50 mg/kg significantly reduced experimental thrombus weight by 62.6% and delayed plasma prothrombin time by 58.7% in rats, whereas 50 and 100 mg/kg of Q808 daily significantly increased serum Ca2+ concentration in mice. Q808 at 0.2, 0.4, and 0.8 mg/mL significantly inhibited thrombin-induced Ca2+ influx in rabbit platelets. Our results suggest that Q808 at 25-200 mg/kg daily exerts anticoagulant and antithrombotic effects, and its mechanisms of action may involve both the intrinsic and extrinsic coagulation pathways that inhibit certain coagulation factors and platelet functions.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 58743-75-2, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, SMILES is N#CC1=CC=C(C2=CC=C(CC)C=C2)C=C1, belongs to phthalazine compound. In a article, author is Ghozlan, Said A. S., introduce new discover of the category.

Azaenamine incorporating pyrazole-4-carboxylate is prepared and allowed to react with alpha,beta-substituted nitriles. A new reactivity pattern was observed leading to the formation of substituted pyrazolo[4′,3′-5,61 pyrimido[2,1-a]phthalazine-9-carbonitriles, which can be considered as aromatic aza-steroid analogues. (C) 2015 Elsevier Ltd. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, molecular formula is C15H13N, belongs to phthalazine compound. In a document, author is Han, Lyrialle W., introduce the new discover, Application In Synthesis of 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile.

Hydralazine, an antihypertensive agent used during pregnancy, undergoes N-acetylation primarily via N-acetyltransferase 2 (NAT2) to form 3-methyl-1,2,4-triazolo[3,4-a]phthalazine (MTP). To characterize the steady-state pharmacokinetics (PK) of hydralazine during pregnancy and evaluate the effects of NAT2 genotype on hydralazine and MTP PK during pregnancy, 12 pregnant subjects received oral hydralazine (5-25 mg every 6 hours) in mid- (n = 5) and/or late pregnancy (n = 8). Serial blood samples were collected over 1 dosing interval, and steady-state noncompartmental PK parameters were estimated. Subjects were classified as either (rapid acetylators, n = 6) or slow acetylators (SAs, n = 6) based on NAT2 genotype. During pregnancy, when compared with the SA group, the RA group had faster weight-adjusted hydralazine apparent oral clearance (70.0 +/- 13.6 vs 20.1 +/- 6.9 L/h, P .05), lower dose-normalized area under the concentration-time curve (AUC; 1.5 +/- 0.8 vs 5.9 +/- 3.7 ng center dot h/mL, P .05), lower dose-normalized peak concentrations (0.77 +/- 0.51 vs 4.04 +/- 3.18 ng/mL, P .05), and larger weight-adjusted apparent oral volume of distribution (302 +/- 112 vs 116 +/- 45 L/kg, P .05). Furthermore, the MTP/hydralazine AUC ratio was similar to 10-fold higher in the RA group (78 +/- 30 vs 8 +/- 3, P .05) than in the SA group. No gestational age or dose-dependent effects were observed, possibly because of the small sample size. This study describes for the first time, the PK of oral hydralazine and its metabolite, MTP, during pregnancy, and confirmed that the PK of oral hydralazine is NAT2 genotype dependent during pregnancy.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, molecular formula is C15H13N, belongs to phthalazine compound. In a document, author is Romero, Angel H., introduce the new discover, Name: 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile.

A series of six 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines were prepared through a facile and efficient one-pot copper-catalyzed procedure from 4-chloro-1-phthalazinyl-arylhydrazones with relatively good yields (62-83%). The one-pot copper-catalytic procedure consists of two simultaneous reactions: (i) a direct intramolecular dehydrogentaive cyclization between ylidenic carbon and adjacent pyrazine nitrogen to form 1,2,4-triazolo ring and, (ii) a direct N-amination on carbon-chlorine bond. Then, an in vitro anticancer evaluation was performed for the synthesized compounds against five selected human cancer cells (A549, MCF-7, SKBr3, PC-3 and HeLa). The nitro-derivatives were significantly more active against cancer strains than against the rest of tested compounds. Specifically, compound 8d was identified as the most promising anticancer agent with significant biological responses and low relative toxicities on human dermis fibroblast. The cytotoxic effect of compound 8d was more significant on PC3, MCF-7 and SKBr3 cancer cells with low-micromolar IC50 value ranging from 0.11 to 0.59 mu M, superior to Adriamycin drug. Mechanistic experimental and theoretical studies demonstrated that compounds 8d act as a K+ channel inhibitor in cancer models. Further molecular docking studies suggest that the EGFR Tyrosine Kinase enzyme may be a potential target for the most active 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 58743-75-2, in my other articles. Name: 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: https://www.ambeed.com/products/58743-75-2.html, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, SMILES is N#CC1=CC=C(C2=CC=C(CC)C=C2)C=C1, belongs to phthalazine compound. In a article, author is Dong, Chune, introduce new discover of the category.

A one-step synthetic protocol for phthalazine derivatives has been developed. In the presence of Et3N, a series of phthalazine derivatives were conveniently prepared in high yield by the reaction of ortho-alkynylphenyl ketones and hydrazine under mild reaction conditions. The structure was unambiguously confirmed by X-ray crystallographic analysis of product 2i.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 58743-75-2 help many people in the next few years. HPLC of Formula: https://www.ambeed.com/products/58743-75-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, molecular formula is C15H13N. In an article, author is Turhan, K.,once mentioned of 58743-75-2, Category: phthalazines.

In this study, substituted 2H-indazolo[2,1-b]phthalazine-1,6,11-triones, that may possess biological activity, have been synthesized via one-pot three-component cyclocondensation reaction of aromatic aldehydes, cyclic 1,3-dione and phthalhydrazide in ethanol catalyzed by Y(OTf)(3) with good to excellent yields. The structures of all synthesized compounds, 3,4-dihydro-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4a), 13-(4-cyanophenyl)-3,4-dihydro-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4b), 3,4-dihydro-3,3-dimethyl-13-(4-cyanophenyl)-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4c), 3,4-dihydro-3,3-dimethyl-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4d), and 3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4e) have been elucidated from IR, NMR and mass spectral data.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, molecular formula is C15H13N. In an article, author is Thirupaiah, Bade,once mentioned of 58743-75-2, Quality Control of 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile.

A one-pot procedure has been developed for the synthesis of substituted 2,3-dihydro-2-(6-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7H-[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazin-3-yl)phthalazine-1,4-diones by reaction of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one, 4-amino-5-hydrazino-4H-[1,2,4]triazole-3-thiol, and phthalic anhydrides in acetic acid medium. Similarly, a one-pot, three-component synthetic procedure has been developed for substituted 3-[3-(N-1-benzylidene-hydrazino)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-4-hydroxy-6-methyl-pyran-2-ones from 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one, 4-amino-5-hydrazino-4H-[1,2,4]triazole-3-thiol, and various aromatic aldehydes in absolute ethanol and a few drops of glacial acetic acid. [Supplementary materials are available for this article. Go to the publisher’s online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, formurla is C15H13N. In a document, author is Dong, Chune, introducing its new discovery. COA of Formula: https://www.ambeed.com/products/58743-75-2.html.

A one-step synthetic protocol for phthalazine derivatives has been developed. In the presence of Et3N, a series of phthalazine derivatives were conveniently prepared in high yield by the reaction of ortho-alkynylphenyl ketones and hydrazine under mild reaction conditions. The structure was unambiguously confirmed by X-ray crystallographic analysis of product 2i.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 58743-75-2 help many people in the next few years. COA of Formula: https://www.ambeed.com/products/58743-75-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Chakraborty, Mou, once mentioned the application of 58743-75-2, Name is 4′-Ethyl-[1,1′-biphenyl]-4-carbonitrile, molecular formula is C15H13N, molecular weight is 207.2704, MDL number is MFCD00799420, category is phthalazine. Now introduce a scientific discovery about this category, Product Details of 58743-75-2.

A controlled tandem synthetic route to azines from various alcohols and hydrazine hydrate by the use of a Ni(II) complex of 2,6-bis(phenylazo)pyridine as a catalyst is reported. In marked contrast to the previous report, the reaction is operative using an earth-abundant metal catalyst, milder reaction conditions, and aerobic conditions, which though are desirable but unprecedented in the literature. The catalytic reaction has a vast substrate scope including a single-step synthesis of phthalazine from 1,2-benzenedimethanol and hydrazine hydrate via intramolecular coupling. Mechanistic investigation suggests that the coordinated ligand redox controls the reaction by the use of a reversible azo (N=N)/hydrazo (NH-NH) redox couple where the metal center is used primarily as a template.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem