Category: 608141-42-0

Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. , Electric Literature of 608141-42-0, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, molecular formula is C12H19NO4S, belongs to phthalazine compound. In a document, author is Bakherad, Mohammad.

A new series of phthalazine-based 1,2,3-triazole derivatives are synthesized by the reaction of 2-methyl-3-(prop-2-yn-1-yl)-2,3dihydro- phthalazine-1,4-dione or 2,3-bis(prop-2-yn-1-yl)-2,3-dihydrophthalaz- ine-1,4-dione with aromatic azides via coppercatalyzed azide-alkyne cycloaddition reactions in the presence of metformine as a ligand. These reaction procedures have the advantages of high-to-excellent yields, short reaction times, mild experimental conditions, and operational simplicity. All the synthesized compounds are screened in vitro for their antibacterial activities against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis. Furthermore, the results of anti-bacterial activity of the synthesized compounds was investigated using molecular docking calculations.

Electric Literature of 608141-42-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 608141-42-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, molecular formula is , belongs to phthalazine compound. In a document, author is Yoosefian, M., HPLC of Formula: https://www.ambeed.com/products/608141-42-0.html.

Properties of dimethyl 3-(alkylamino)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine-1,2-dicarboxylate and its derivatives were studied by means of ab initio method. NO2 derivative of title compound was synthesized and the nature of its intramolecular hydrogen bond (HB) was investigated. Furthermore, the topological properties of the electron density distributions for N-H…O intramolecular bridges were analyzed in terms of the Bader theory of atoms in molecules (AIM). The electron density (?) and Laplacian (?2?) properties, estimated by AIM calculations, indicated that O…H bond possesses low ? and positive ?2? values which are in agreement with electrostatic character of the HBs, whereas N-H bonds have covalent character (?2?<0). Moreover, steric effect of the t-Bu group on structure and topological parameters of pyrazolo[1,2-b]phthalazine conformers was studied. Finally, the powerful method of Espinosa was used to obtain the H-bond energy. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 608141-42-0, in my other articles. HPLC of Formula: https://www.ambeed.com/products/608141-42-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, SMILES is O=S(C[C@@H](N)C1=CC=C(OC)C(OCC)=C1)(C)=O, belongs to phthalazine compound. In a document, author is Im, Jeong Kyun, introduce the new discover, SDS of cas: 608141-42-0.

A rarely explored oxidative ring contraction of electron-rich 1,2-diazine is described. Upon treatment with an electrophilic chlorinating reagent (TCICA), 1,4-dimethoxyphthalazines undergo an N-chlorination-induced ring contraction that is accompanied by the loss of one nitrogen atom. The scope of this unusual reactivity was examined with a range of 1,4-dimethoxyphthalazine derivatives. In addition, a mechanism proceeding via a bicyclic species was proposed on the basis of an isolated reaction intermediate and DFT calculations. (C) 2020 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 608141-42-0 is helpful to your research. SDS of cas: 608141-42-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, HPLC of Formula: https://www.ambeed.com/products/608141-42-0.html608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, SMILES is O=S(C[C@@H](N)C1=CC=C(OC)C(OCC)=C1)(C)=O, belongs to phthalazine compound. In a article, author is Heirati, Seyedeh Zahra Dalil, introduce new discover of the category.

In this work, a series of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products were efficiently synthesized for the first time using O-Sulfonic acid poly(4-vinylpyrrolidonium) chloride ([PVP-SO3H]Cl) as an eco-friendly polymer-supported catalyst. At first, the catalyst preparation process was optimized based on the chlorosulfonic acid amount and the sulfonation time to obtain a catalyst with the maximum acidity content. The maximum acidity content for [PVP-SO3H]Cl was obtained to be 3.31 mmol g(-1). Then, the optimized [PVP-SO3H]Cl was used as a catalyst for the synthesis of a series of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products. It was observed that only 10 mg of the catalyst was enough to catalyze these reactions under mild conditions, and the corresponding products were obtained in high to excellent yields. Moreover, the catalyst could be repeatedly used for at least five times without a noticeable decrease in its catalytic activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 608141-42-0. HPLC of Formula: https://www.ambeed.com/products/608141-42-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine. In a document, author is Azarifar, Davood, introducing its new discovery. Name: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

Tetrakis(acetonitrile) copper(I) hexafluorophosphate, [Cu(CH3CN)(4)]PF6, was explored as an efficient catalyst to promote the three-component reaction of aryl aldehydes, dimedone and urazole or phthalhydrazide to afford the corresponding triazolo[1,2-a]indazole-1,3,8-trione and 2H-indazolo[2,1-b]phthalazine-trione derivatives respectively in high yields. The reactions were conducted at 80-100 degrees C under solvent-free conditions. The catalyst was easily prepared from available and inexpensive materials and was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles with almost consistent activity.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 608141-42-0 help many people in the next few years. Name: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, SMILES is O=S(C[C@@H](N)C1=CC=C(OC)C(OCC)=C1)(C)=O, in an article , author is Shamsi-Sani, Mahnaz, once mentioned of 608141-42-0, HPLC of Formula: https://www.ambeed.com/products/608141-42-0.html.

Butane-1-soltunic acid modified starch-coated gamma-Fe2O3 magnetic nanoparticles (gamma-Fe2O3 @starchn-butyl SO3H] was easily prepared through a ring opening reaction of 1,4-butane sultone with nanomagnetic gamma-Fe2O3 @starch. After structural studies, using FT-IR, SEM, XRD, TGA, TEM, EDX, VSM and also pH analysis the efficiency of this reagent in the preparation of tetrahydrobenzimidazo[2,1-b] quinazolin-1(2H)-ones and 2H-indazolo[2,1-b]phthalazine-triones was studied. Operational simpleness, high yields, short reaction times, wide applicability and simple recyclability of the catalyst employing an external magnet are the most important advantages of this methodology.

Interested yet? Read on for other articles about 608141-42-0, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/608141-42-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, SMILES is O=S(C[C@@H](N)C1=CC=C(OC)C(OCC)=C1)(C)=O, belongs to phthalazine compound. In a document, author is El-Helby, Abdel-Ghany A., introduce the new discover, Name: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

Novel series of phthalazine derivatives 6-11 were designed, synthesized, and evaluated for their anticancer activity against two human tumor cell lines, HCT-116 human colon adenocarcinoma and MCF-7 breast cancer cells, targeting the VEGFR-2 enzyme. Compounds 7a,b and 8b,c showed the highest anticancer activities against both HCT116 human colon adenocarcinoma cells with IC50 of 6.04 +/- 0.30, 13.22 +/- 0.22, 18 +/- 0.20, and 35 +/- 0.45M, respectively, and MCF-7 breast cancer cells with IC50 of 8.8 +/- 0.45, 17.9 +/- 0.50, 25.2 +/- 0.55, and 44.3 +/- 0.49M, respectively, in comparison to sorafenib as reference drug with IC50 of 5.47 +/- 0.3 and 7.26 +/- 0.3M, respectively. Eleven compounds in this series were further evaluated for their inhibitory activity against VEGFR-2, where compounds 7a, 7b, 8c, and 8b also showed the highest VEGFR-2 inhibition with IC50 of 0.11 +/- 0.01, 0.31 +/- 0.03, 0.72 +/- 0.08, and 0.91 +/- 0.08M, respectively, in comparison to sorafenib as reference ligand with IC50 of 0.1 +/- 0.02. Furthermore, molecular docking studies were performed for all synthesized compounds to predict their binding pattern and affinity towards the VEGFR-2 active site, in order to rationalize their anticancer activity in a qualitative way.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 608141-42-0 is helpful to your research. Name: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, molecular formula is C12H19NO4S, belongs to phthalazine compound, is a common compound. In a patnet, author is Safari, Niloufar, once mentioned the new application about 608141-42-0, Product Details of 608141-42-0.

In current study, a new DABCO based tetra cationic ionic liquid, formulated as [C-4(H-DABCO)(2)][HSO4](4) is easily prepared and characterized using FT-IR, H-1 NMR,C-13 NMR, TGA, and DTG analysis, and also pH-metric titration method. In continue, the efficiency of the prepared catalyst in the acceleration of the synthesis of 2H-indazolo[2,1-b]phthalazine-trione and [1,2,4]triazoloquinazolinone derivatives, is investigated. Simple experimental procedure, using available and low-cost starting materials for the preparation of the catalyst, reusability of the catalyst, isolation of products without using chromatographic methods, short reaction times, high isolated yields, and solvent-free conditions are the most important features of the present method. (C) 2019 Elsevier B.V. All rights reserved.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 608141-42-0. The above is the message from the blog manager. Product Details of 608141-42-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, molecular formula is C12H19NO4S. In an article, author is Jia, Xiao-chuan,once mentioned of 608141-42-0, Quality Control of (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

A Simple and Green Protocol for 2H-Indazolo[2,1-b]phthalazine-triones Using Grinding Method

A robust, facile, and solvent-free route for the three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones in the presence of a catalytic amount of p-toluene sulfonic acid utilizing grinding has been developed. Short reaction time, simple operation, and high yields are the advantages of this protocol.

Interested yet? Keep reading other articles of 608141-42-0, you can contact me at any time and look forward to more communication. Quality Control of (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, molecular formula is C12H19NO4S, belongs to phthalazine compound, is a common compound. In a patnet, author is Komkov, Alexander V., once mentioned the new application about 608141-42-0, Formula: https://www.ambeed.com/products/608141-42-0.html.

A Straightforward Approach toward Multifunctionalized Pyridazines via Imination/Electrocyclization

A facile synthesis of functionalized 3-carbamide pyridazines starting from readily available chlorovinyl aldehydes and oxamic acid thiohydrazides via cascade imination/electrocyclization is reported. In the presence of p-toluenesulfuric acid, various ketones have been efficiently incorporated into the pyridazine derivatives through a two-step sequence involving a VilsmeierHaack reaction and imination. The synthetic value of this method has been demonstrated by efficient synthesis of steroidal pyridazines.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 608141-42-0. The above is the message from the blog manager. Formula: https://www.ambeed.com/products/608141-42-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem