Category: 611-73-4

Recommanded Product: 611-73-4, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)=O, belongs to phthalazine compound. In a article, author is El-Helby, Abdel-Ghany A., introduce new discover of the category.

Herein we report the design and synthesis of a new series of phthalazine derivatives as Topo II inhibitors and DNA intercalators. The synthesized compounds were in vitro evaluated for their cytotoxic activities against HepG-2, MCF-7 and HCT-116 cell lines. Additionally, Topo II inhibitory activity and DNA intercalating affinity were investigated for the most active compounds as a potential mechanism for the anticancer activity. Compounds 15h, 23c, 32a, 32b, and 33 exhibited the highest activities against Topo II with IC50, ranging from 5.44 to 8.90 mu M, while compounds 27 and 32a were found to be the most potent DNA binders at IC50, values of 36.02 and 48.30 mu M, respectively. Moreover, compound 32a induced apoptosis in HepG-2 cells and arrested the cell cycle at the G2/M phase. Besides, compound 32a showed Topo II poisoning effect at concentrations of 2.5 and 5 mu M, and Topo II catalytic inhibitory effect at a concentration of 10 mu M. In addition, compound 32b showed in vivo a significant tumor growth inhibition effect. Furthermore, molecular docking studies were carried out against DNA-Topo II complex and DNA to investigate the binding patterns of the designed compounds.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 611-73-4 is helpful to your research. Recommanded Product: 611-73-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 2-Oxo-2-phenylacetic acid, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)=O, belongs to phthalazine compound. In a article, author is Reilly, Sean W., introduce new discover of the category.

Development of poly(ADP-ribose) polymerase inhibitors (PARPi’s) continues to be an attractive area of research due to synthetic lethality in DNA repair deficient cancers; however, PARPi’s also have potential as therapeutics to prevent harmful inflammation. We investigated the pharmacological impact of incorporating spirodiamine motifs into the phthalazine architecture of FDA approved PARPi olaparib. Synthesized analogues were screened for PARP-1 affinity, enzyme specificity, catalytic inhibition, DNA damage, and cytotoxicity. This work led to the identification of 10e (12.6 +/- 1.1 nM), which did not induce DNA damage at similar drug concentrations as olaparib. Interestingly, several worst in class compounds with low PARP-1 affinity, including 15b (4397 +/- 1.1 nM), induced DNA damage at micromolar concentrations, which can explain the cytotoxicity observed in vitro. This work provides further evidence that high affinity PARPi’s can be developed without DNA damaging properties offering potential new drugs for treating inflammatory related diseases.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment., Application of 611-73-4, 611-73-4, Name is 2-Oxo-2-phenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)=O, belongs to phthalazine compound. In a document, author is Aly, M. R. E., introduce the new discover.

This paper describes the synthesis of a series of quinolines graphted with hydrazones, pyrazoles, pyridazine, phthalazine, triazepinone, semicarbazide, and thiomorpholide moieties and four metal complexes. These derivatives were screened against Fusarium oxysporum and the red palm weevil (RPW) Rhynchophorus ferrugineus Oliver (coleopteran: Curculionidae) as palm pathogens. Only chlorinated quinolines were active against these organisms with hydrazones being good fungicides, while those modified with pyrazoles and pyrazines showed moderate insecticidal activity. A unique trihydroxylated hydrazone was active against both organisms, while another hydrazone, the most potent fungicide in this series, exhibited insecticidal activity only upon complexation with Zn2+ ions.

Application of 611-73-4, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 611-73-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is C8H6O3, belongs to phthalazine compound. In a document, author is Mironov, Maxim A., introduce the new discover, Electric Literature of 611-73-4.

Multicomponent reactions between phthalazine, alkyl isocyanides, and 1,1-dicyanoalkenes in acetonitrile-water mixture produced high yields of substituted pyrrolo[2,1-a]phthalazines, which were converted upon treatment with 10% hydrochloric acid to pyrrolo[2,1-a]-phthalazines unsubstituted at position 1. As a result, a range of new pyrrolo[2,1-a]phthalazine derivatives have been synthesized by this one-pot approach.

Electric Literature of 611-73-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 611-73-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 611-73-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)=O, belongs to phthalazine compound. In a article, author is Gao, Cheng-Zhi, introduce new discover of the category.

A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound 5l exhibited the most potent inhibitory effects on PARP-1 enzyme (16.10 +/- 1.25 nM) and MDA-MB-436 cancer cell (11.62 +/- 2.15 mu M), which was close to that of Olaparib. As a PARP-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (MTDLs) for the treatment of Alzheimer’s disease (AD), the inhibitory activities of the synthesized compounds against the enzymes AChE (from electric eel) and BChE (from equine serum) were also tested. Compound 5l displayed moderate BChE inhibitory activity (9.16 +/- 0.91 mu M) which was stronger than neostigmine (12.01 +/- 0.45 mu M) and exhibited selectivity for BChE over AChE to some degree. Molecular docking studies indicated that 5l could bind simultaneously to the catalytic active of PARP-1, but it could not interact well with huBChE. For pursuit of PARP-1 and BChE dual-targeted inhibitors against AD, small and flexible non-polar groups introduced to the compound seemed to be conducive to improving its inhibitory potency on huBChE, while keeping phthalazine-1-one moiety unchanged which was mainly responsible for PARP-1 inhibitory activity. Our research gave a clue to search for new agents based on AChE and PARP-1 dual-inhibited activities to treat Alzheimer’s disease.

Synthetic Route of 611-73-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 611-73-4 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, formurla is C8H6O3. In a document, author is Xue, Jie, introducing its new discovery. Recommanded Product: 2-Oxo-2-phenylacetic acid.

Despite the great potential for applications spanning, from military night-vision displays and information-secured devices to civilian medical diagnostics and phototherapy, the development of highly efficient, stable, and low-cost near-infrared (NIR) emitting lumophores is still a formidable challenge. Herein, we report two novel NIR-emitting homoleptic facial Ir(III) complexes based on extended pi-conjugated benzo[g]phthalazine ligands, namely, tris[1,4-di(thiophen-2-yl)benzo(g]phthalazine] (Ir(dtbpa)(3), 1) and tris[1-(2,4-bis(trifluoromethyl)pheny1)-4-(thiophen-2-y1)-benzo[g]phthalazine] iridium(III) (Ir(Ftbpa)(3), 2). Actually, these two ligarids not only enable simple one-pot synthesis of homoleptic Ir(III) complexes without any catalyst under mild conditions, but also contribute to intense NIR-emission with high photoluminescence quantum yield up to 5.2% at 824 nm for 1 and 17.3% at 765 nm for 2 respectively. Single-crystal structure of 1 demonstrates desired facial form with short Ir-N and Ir-C bonds because of strong coordination and small steric hindrance of those highly conjugated C<^>N=N ligands. Importantly, the incorporation Of CF3 groups in 2 further leads to high thermal stability and a good ability to sublime, thus resulting in ultrapurity for highly efficient NIR-organic light-emitting diodes (NIR-OLEDs) with a high maximum external quantum efficiency of 4.5% at 760 run and small efficiency roll-off remaining of 3.5% at 100 mA. cm(-2), values which rank with those of the most efficient NIR-OLEDs with small roll-off and peak emission over 750 nm. Notably, the content percentages of the noble metal in these two complexes, (similar to 10% Ir) are markedly lower by about two-thirds than that of typical green-emitting tris(2-phenylpyridine)iridium (similar to 30% Ir). The findings may provide a new strategy to develop robust NIR emitters and achieve high efficiency, small roll-off, and low cost simultaneously in NIR-OLEDs for practical applications.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 611-73-4 help many people in the next few years. Recommanded Product: 2-Oxo-2-phenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is C8H6O3. In an article, author is Jahanshahi, Parivash,once mentioned of 611-73-4, Recommanded Product: 611-73-4.

A novel one-pot four-component, highly efficient and environmentally benign approach for the synthesis of a wide range of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives in the presence of acetic acid functionalized imidazolium salt (1-carboxymethyl-2,3-dimethylimidazolium iodide {[cmdmim]I}) as a newly synthesized BrOnsted acid catalyst is described. The reaction occurs via tandem Knoevenagel-cyclocondensation of phthalic anhydride, hydrazine hydrate, aromatic aldehydes and 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile (or 3-(1H-indol-3-yl)-3-oxopropanenitrile) in the presence of acetic acid functionalized imidazolium salt {[cmdmim]I} in ethanol under reflux conditions. This adequate procedure possesses some advantages like atom economy, cost-effectiveness, operational simplicity, short reaction times, straightforward work-up procedure, high yields, and reusability of the catalyst in 5 consecutive runs without any appreciable decrease in activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 611-73-4, 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is C8H6O3, belongs to phthalazine compound. In a document, author is Coelho, Catarina, introduce the new discover.

Aldehyde oxidase (AOX) is a xanthine oxidase (XO)-related enzyme with emerging importance due to its role in the metabolism of drugs and xenobiotics. We report the first crystal structures of human AOX1, substrate free (2.6-angstrom resolution) and in complex with the substrate phthalazine and the inhibitor thioridazine (2.7-angstrom resolution). Analysis of the protein active site combined with steady-state kinetic studies highlight the unique features, including binding and substrate orientation at the active site, that characterize human AOX1 as an important drug-metabolizing enzyme. Structural analysis of the complex with the noncompetitive inhibitor thioridazine revealed a new, unexpected and fully occupied inhibitor-binding site that is structurally conserved among mammalian AOXs and XO. The new structural insights into the catalytic and inhibition mechanisms of human AOX that we now report will be of great value for the rational analysis of clinical drug interactions involving inhibition of AOX1 and for the prediction and design of AOX-stable putative drugs.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 611-73-4. Product Details of 611-73-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.611-73-4, Name is 2-Oxo-2-phenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)=O, belongs to phthalazine compound. In a document, author is Bakherad, Mohammad, introduce the new discover, Recommanded Product: 611-73-4.

The reaction of 1-chloro-4-propargylaminophthalazine with various aryl halides catalyzed by Pd-Cu in the presence of potassium carbonate, as the base, in water leads to the one-pot formation of new derivatives of 3-aryl-substituted-6-chloroimidazo-[2,1-a]phthalazines in moderate-to-good yields. Their structures are confirmed by IR and NMR spectra as well as elemental analyses. All the compounds prepared are screened invitro for their anti-bacterial activities. The preliminary results indicate that some target compounds exhibit promising anti-bacterial potency.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 611-73-4 is helpful to your research. Recommanded Product: 611-73-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , COA of Formula: C8H6O3, 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is C8H6O3, belongs to phthalazine compound. In a document, author is Shaterian, Hamid Reza, introduce the new discover.

Mild basic ionic liquids catalyzed new four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

A new four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using three weak basic ionic liquids such as 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate, pyrrolidinium formate, and pyrrolidinium acetate as efficient catalysts for condensation reaction of hydrazine monohydrate, phthalic anhydride, malononitrile or ethyl cyanoacetate, and aromatic aldehydes under ambient and solvent-free conditions in excellent yields is described. (C) 2012 Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 611-73-4. COA of Formula: C8H6O3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem