Category: 611-73-4

In an article, author is Qiu, Feng, once mentioned the application of 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is C8H6O3, molecular weight is 150.1314, MDL number is MFCD00002575, category is phthalazines. Now introduce a scientific discovery about this category, Category: phthalazines.

Asymmetric Boron-Cored Aggregation-Induced Emission Luminogen with Multiple Functions Synthesized through Stepwise Conversion from a Symmetric Ligand

Multifunction luminogens have emerged as promising candidates in high-performance sensor and imaging systems. Concise approaches to the synthesis of such molecules are urgently required both for fundamental research and technological applications. In this study, a new symmetric ligand of di(2-hydroxyphenyl)phthalazine with multiple binding sites around a phthalazine unit was readily synthesized, which could be converted efficiently into an asymmetric luminogen (OBNDHPP) through the formation of oxygen-boron-nitrogen bonding. This molecule has a twistable it-extended backbone with a tetracoordinated boron core bearing two bulky phenyl groups, giving it abundant optical properties including a large Stokes shift piezochromism and aggregationinduced emission enhancement. Importantly, the presence of a free phenolic hydroxyl group in the backbone of OBN-DHPP enables the incorporation of various functional moieties into the asymmetric luminogen. As an example, polyethylene glycol (PEG)-modified luminogen (OBN-DHPP-PEG(45)) was synthesized. In the aqueous medium, OBN-DHPP-PEG(45) could self-assemble into spherical nanoparticles with low cytotoxicity and excellent emission performance as well as high solubility. The results of flow cytometry and fluorescence microscopy reveal that these nanoparticles could be internalized successfully by HeLa cells, demonstrating their potential application in bioimaging.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.611-73-4, Name is 2-Oxo-2-phenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)=O, belongs to phthalazines compound. In a document, author is El-Helby, Abdel-Ghany A., introduce the new discover, Computed Properties of C8H6O3.

Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors

Herein we report the design and synthesis of a new series of phthalazine derivatives as Topo II inhibitors and DNA intercalators. The synthesized compounds were in vitro evaluated for their cytotoxic activities against HepG-2, MCF-7 and HCT-116 cell lines. Additionally, Topo II inhibitory activity and DNA intercalating affinity were investigated for the most active compounds as a potential mechanism for the anticancer activity. Compounds 15h, 23c, 32a, 32b, and 33 exhibited the highest activities against Topo II with IC50, ranging from 5.44 to 8.90 mu M, while compounds 27 and 32a were found to be the most potent DNA binders at IC50, values of 36.02 and 48.30 mu M, respectively. Moreover, compound 32a induced apoptosis in HepG-2 cells and arrested the cell cycle at the G2/M phase. Besides, compound 32a showed Topo II poisoning effect at concentrations of 2.5 and 5 mu M, and Topo II catalytic inhibitory effect at a concentration of 10 mu M. In addition, compound 32b showed in vivo a significant tumor growth inhibition effect. Furthermore, molecular docking studies were carried out against DNA-Topo II complex and DNA to investigate the binding patterns of the designed compounds.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 611-73-4 is helpful to your research. Computed Properties of C8H6O3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, molecular formula is C8H6O3. In an article, author is Moustafa, Ahmed H.,once mentioned of 611-73-4, COA of Formula: C8H6O3.

Synthesis, Antiviral, and Antimicrobial Activity of N- and S-Alkylated Phthalazine Derivatives

A series of N-alkylphthalazinone were synthesized by the reaction of phthalazin-1(2H)-one derivatives 1a-c with alkylating agents namely, propargyl, allyl bromide, epichlorohydrin, 1,3-dichloro-2-propanol, 4-bromobutylacetate, and 1-(bromomethoxy) ethyl acetate to give the corresponding N-alkylphthalazinone 2a-c, 3a-c, 5a-c, 6a-c, 7a-c, and 9a-c. Alkylation of phthalazin-1(2H)-thione to give a series from S-alkylphthalazine 12-14 and thioglycosides 15 and 17 was performed. Deprotection of compounds 7a-c, 9a-c, 15, and 17 resulted in the formation of the corresponding products 8a-c, 10a-c, 16, and 18. The structure of newly synthesized compounds was assigned by IR, H-1, C-13 NMR, and elemental analysis. Some of these compounds were screened for antiviral and antimicrobial activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 611-73-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 611-73-4, Name is 2-Oxo-2-phenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)=O, belongs to phthalazines compound. In a article, author is Aly, M. R. E., introduce new discover of the category.

Synthesis, Insecticidal, and Fungicidal Screening of Some New Quinoline Derivatives

This paper describes the synthesis of a series of quinolines graphted with hydrazones, pyrazoles, pyridazine, phthalazine, triazepinone, semicarbazide, and thiomorpholide moieties and four metal complexes. These derivatives were screened against Fusarium oxysporum and the red palm weevil (RPW) Rhynchophorus ferrugineus Oliver (coleopteran: Curculionidae) as palm pathogens. Only chlorinated quinolines were active against these organisms with hydrazones being good fungicides, while those modified with pyrazoles and pyrazines showed moderate insecticidal activity. A unique trihydroxylated hydrazone was active against both organisms, while another hydrazone, the most potent fungicide in this series, exhibited insecticidal activity only upon complexation with Zn2+ ions.

Electric Literature of 611-73-4, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 611-73-4.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem