Category: 62-23-7

Product Details of 62-23-7. In 2019 EUR J MED CHEM published article about ACUTE MYELOID-LEUKEMIA; KINASE INHIBITOR; MUTATIONS; SORAFENIB; DISCOVERY; OUTCOMES; MUTANTS; POTENT in [Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Lu, Shuai] China Pharmaceut Univ, Sch Sci, Nanjing 211198, Jiangsu, Peoples R China; [Zhi, Yanle] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Henan, Peoples R China; [Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; [Chen, Yadong] China Pharmaceut Univ, Lab Mol Design & Drug Discovery, Nanjing 211198, Jiangsu, Peoples R China; [Lu, Tao] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China in 2019, Cited 32. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

FLT3 mutation is among the most common genetic mutations in acute myeloid leukemia (AML), which is also related with poor overall survival and refractory in AML patients. Recently, FLT3 inhibitors have been approved for AML therapy. Herein, a series of new compounds with pyrazole amine scaffold was discovered, which showed potent inhibitory activity against FLT3-ITD and significant selectivity against both FLT3-ITD and AML cells expressing FLT3-ITD. Compound 46, possessing the most promising cellular activity, blocked the autophosphorylation of FLT3 pathway in MV4-11 cell line. Furthermore, the apoptosis and downregulation of P-STAT5 were also observed in tumor cells extracted from the MV411 cell xenografts model upon compound 46 treatment. Compound 46 was also metabolically stable in vitro and suppressed tumor growth significantly in MV4-11 xenografts model in vivo. Compound 46 showed no toxicity to the viscera of mice and caused no decrease in body weight of mice. In conclusion, the results of this study could provide valuable insights into discovery of new FLT3 inhibitors, and compound 46 was worthy of further development as potential drug candidate to treat AML (C) 2019 Elsevier Masson SAS. All rights reserved.

Product Details of 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Heng, H; Wang, ZJ; Li, HM; Huang, YT; Lan, QY; Guo, XX; Zhang, L; Zhi, YL; Cai, JH; Qin, TR; Xiang, L; Wang, SX; Chen, YD; Lu, T; Lu, S or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about HETEROAROMATIC AMINES; AMES TEST; MUTAGENICITY; QSAR; RISK; HYDROCARBONS; EPIDEMIOLOGY; PERMEABILITY; METABOLISM; OXIDATION, Saw an article supported by the Key Projects of Scientific Research of the Education Department of Sichuan Province [17ZA0303]; Key Projects of Science & Technology Department of Sichuan Province [2017SZ0173]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Wan, WX; Chen, Y; Zhang, J; Shen, F; Luo, L; Deng, SH; Xiao, H; Zhou, W; Deng, OP; Yang, H; Xiao, YL; Huang, CR; Tian, D; He, JS; Wang, YJ. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. COA of Formula: C7H5NO4

Cancer is a leading cause of human mortality around the globe. In this study, mechanism-based SAR (Structure Activity Relationship) was employed to investigate the carcinogenicity of aromatic amines and nitroaromatics based on CPDB. Principal component analysis and cluster analysis were used to construct the SAR model. Principle component analysis generated three principal components from 12 mechanism-based descriptors. The extracted principal components were later used for cluster analysis, which divided the selected 55 chemicals into six clusters. The three principal components were proposed to describe the transport, reactivity and electrophilicity properties of the chemicals. Cluster analysis indicated that the relevant transport properties positively correlated with the carcinogenic potential and were contributing factors in determining the cardnogenicity of the studied chemicals. The mechanism-based SAR analysis suggested the electron donating groups, electron withdrawing groups and planarity are significant factors in determining the carcinogenic potency for studied aromatic compounds. The present study may provide insights into the relationship between the three proposed properties and the carcinogenesis of aromatic amines and nitroaromatics.

COA of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Wan, WX; Chen, Y; Zhang, J; Shen, F; Luo, L; Deng, SH; Xiao, H; Zhou, W; Deng, OP; Yang, H; Xiao, YL; Huang, CR; Tian, D; He, JS; Wang, YJ or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ORG CHEM FRONT published article about ASYMMETRIC-SYNTHESIS; QUATERNARY CARBON; ALPHA(2C)-ADRENOCEPTOR ANTAGONIST; STEREOSELECTIVE CONSTRUCTION; REDUCTION; DELTA(3)-2-HYDROXYBAKUCHIOL; ACIDS in [Ma, Qiaoning; Lei, Xinsheng; Lin, Guo-Qiang] Fudan Univ, Inst Biomed Sci, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Ma, Qiaoning; Lei, Xinsheng; Lin, Guo-Qiang] Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Yang, Xiaodi; Lin, Guo-Qiang] Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, Shanghai 201203, Peoples R China; [Lin, Guo-Qiang] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Key Lab Synthet Chem Nat Subst, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019.0, Cited 32.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

The preparation of ORM-10921, a selective (2C)-adrenoceptor antagonist with promising anti-psychotic properties, was successfully achieved using asymmetric -alkylation of ,-unsaturated imide and Bischler-Napieralski cyclization/asymmetric reduction as the key steps. When the tetracyclic iminium 11S was used in the reduction, the diastereo-selectivity was poor, from which four stereoisomers of ORM-10921 were obtained, respectively. However, the diastereoselectivity could be significantly improved (with dr up to >97:3) when the tricyclic imine substrate 19S was applied in this reduction, suggesting an additional chelation from the side-chain methoxy group in the transition state. According to this protocol, ORM-10921 was accomplished in a highly enantioselective manner. In addition, two analogs 26Aa and 26Ba were prepared using this novel method, and the absolute configurations were unambiguously assigned by single crystal X-ray crystallography.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Ma, QN; Yang, XD; Lei, XS; Lin, GQ or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis, biological evaluation and mechanism studies of C-23 modified 23-hydroxybetulinic acid derivatives as anticancer agents published in 2019. Computed Properties of C7H5NO4, Reprint Addresses Xu, JY (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China.; Xu, JY (corresponding author), China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China.; Liu, J (corresponding author), China Pharmaceut Univ, Dept Organ Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A series of C-23 modified 23-hydroxybetulinic acid (HBA) derivatives were synthesized and evaluated for their antiproliferative activity against a panel of cancer cell lines (A2780, A375, B16, MCF-7 and HepG2). The biological screening results showed that most of the derivatives exhibited more potent antiproliferative activity than HBA, and compound 6e exhibited the most potent activity with IC50 values of 2.14 mu M, 2.89 mu M, and 3.97 mu M against A2780, B16, and MCF-7 cells, respectively. Further anticancer mechanism studies revealed that compound 6e induced the generation of intracellular reactive oxygen species (ROS) and reduction of mitochondrial membrane potential (MMP) of B16 cells in a dose-dependent manner. Moreover, western blot analysis indicated that compound 6e downregulated the expression of anti-apoptotic protein Bcl-2 and upregulated the expression of proapoptotic protein Bax, activation of caspase 3 to induce cell apoptosis. Meanwhile, compound 6e significantly inhibited the phosphorylation of MEK, ERK, and Akt without affecting the expression of MEK, ERK, and Akt. Furthermore, the in vivo anti-tumor activity of 6e was validated (tumor inhibitory ratio of 68.4% at the dose of 30 mg/kg) in mice with B16 melanoma. (C) 2019 Elsevier Masson SAS. All rights reserved.

Computed Properties of C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Lu, LX; Zhang, HY; Liu, J; Liu, Y; Wang, YW; Xu, ST; Zhu, ZY; Xu, JY or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. In 2019.0 TETRAHEDRON LETT published article about PHOSPHONIUM IONIC LIQUIDS; AROMATIC-COMPOUNDS; SOLVOLYTIC BEHAVIOR; SELECTIVE NITRATION; ARYLBORONIC ACIDS; HIGHLY EFFICIENT; SULFONIC-ACID; METAL; CHEMISTRY; CATALYST in [Natarajan, Palani] Panjab Univ, Dept Chem, Chandigarh 160014, India; Panjab Univ, Ctr Adv Studies Chem, Chandigarh 160014, India in 2019.0, Cited 83.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

An eco-friendly and a simple ipso-nitration protocol for a series of aliphatic and (hetero)aromatic carboxylic acids using nitronium tetrafluoroborate, 1-hexyl-3,4,5-trimethyl-1H-imidazolium tetrafluoroborate and base is reported. While contrasted with recently known decarboxylative ipso-nitration strategies for the preparation of nitro compounds, this protocol does not require a toxic metal catalyst and harmful volatile organic solvents. Moreover, this method is perfect for a broad range of functional groups and affords exclusively the ipso-nitrated product in moderate to good yields. (C) 2019 Elsevier Ltd. All rights reserved.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Natarajan, P; Chaudhary, R; Venugopalan, P or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. In 2019.0 ORG LETT published article about TRACELESS DIRECTING GROUPS; CARBOXYLIC-ACIDS; ENANTIOSELECTIVE SYNTHESIS; COUPLING REACTIONS; ORTHO-ARYLATION; BENZOIC-ACIDS; IODINE; ACTIVATION; BIARYLS; ALKYNES in [Hu, Tao; Xu, Kai; Ye, Zenghui; Zhu, Kai; Zhang, Fengzhi] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China; [Wu, Yanqi] Zhejiang Univ Technol, Inst Informat Resource, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 63.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

We report here a two-in-one strategy for the Pd(II)-catalyzed tandem C-H arylation/decarboxylative annulation between readily available cyclic diaryliodonium salts and benzoic acids. The carboxylic acid functionality can be used as both a directing group for the ortho-C-H arylation and the reactive group for the tandem decarboxylative annulation. By a step-economical double cross-coupling annulation procedure, the privileged triphenylene frameworks were efficiently constructed, which have potential applications in material chemistry.

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hu, T; Xu, K; Ye, ZH; Zhu, K; Wu, YQ; Zhang, FZ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CONTINUOUS-FLOW SYNTHESIS; O-QUINODIMETHANES; ALDEHYDES; BENZYLATION; REDUCTION; CHEMISTRY; EFFICIENT; CATALYST, Saw an article supported by the Department of Science and Technology, New Delhi (Govt. of India) (DST)Department of Science & Technology (India); CSIRCouncil of Scientific & Industrial Research (CSIR) – India [MLP-32]; DSTDepartment of Science & Technology (India); Science and Engineering Research Board (SERB) [DST/INSPIRE/04/2016/000247, ECR/2017/000208]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Aand, D; Mahajan, B; Pabbaraja, S; Singh, AK. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Name: 4-Nitrobenzoic acid

Direct utilization of the abundant hydrogen in water for the transfer hydrogenation reaction (THR) is a very attractive and challenging research area. Herein, we report the first integrated photo-transfer hydrogenation reaction (PTHR) platform for the synthesis of benzhydrol derivatives (26 examples, 33-89% yields) with water as a green reducing agent. This transformation is time and labor-efficient, catalyst-free, and economical and utilizes readily available hydrocarbon(s) (o-methyl phenyl ketones) as starting materials.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Aand, D; Mahajan, B; Pabbaraja, S; Singh, AK or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design and evaluation of Nrf2 activators with 1,3,4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells published in 2020.0, Reprint Addresses Sun, HP (corresponding author), China Pharmaceut Univ, Dept Med Chem, Nanjing 211198, Jiangsu, Peoples R China.; Feng, F (corresponding author), Jiangsu Food & Pharmaceut Sci Coll, Huaian 223003, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Oxidative stress plays vital roles in virous neurodegenerative diseases including Alzheimer’s disease. Activation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), the key regulator of oxidative stress, may provide a new therapeutic strategy for these diseases. Herein we synthesized and evaluated a series of 1,3,4-oxa/thiadiazole core Nrf2 activators as neuroprotective agents. The representative compound 8 exhibited cytoprotective and Nrf2 activation effects in a neuron-like PC-12 cells. Additionally, compound 8 showed good membrane permeability, indicating this compound could penetrate blood-brain barrier (BBB) to reach central nervous system (CNS) as a neuro-protective agent. These results indicated that these Nrf2 activators with 1,3,4-oxa/thiadiazole core could serve as a new chemotype against oxidative stress in neurodegenerative diseases.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Lin, HZ; Qiao, YT; Yang, HY; Li, Q; Chen, Y; Qu, W; Liu, WY; Feng, F; Sun, HP or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 4-Nitrobenzoic acid. Recently I am researching about CARBON-DIOXIDE; CYCLOHEXENE OXIDE; ALTERNATING COPOLYMERIZATION; CO2/EPOXIDE COPOLYMERIZATION; ASYMMETRIC COPOLYMERIZATION; TRIBLOCK COPOLYMERS; CYCLOPENTENE OXIDE; DIZINC CATALYST; MG-ZN; CO2, Saw an article supported by the EPSRCUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/L017393/1, EP/K014668/1]; Climate KIC. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Trott, G; Garden, JA; Williams, CK. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The ring-opening copolymerization of carbon dioxide and epoxides is a useful means to make aliphatic polycarbonates and to add-value to CO2. Recently, the first heterodinuclear Zn(II)/Mg(II) catalyst showed greater activity than either homodinuclear analogue (J. Am. Chem. Soc. 2015, 137, 15078-15081). Building from this preliminary finding, here, eight new Zn(II)/Mg(II) heterodinuclear catalysts featuring carboxylate co-ligands are prepared and characterized. The best catalysts show very high activities for copolymerization using cyclohexene oxide (TOF 1/4 8880 h 1, 20 bar CO2, 120 C, 0.01 mol% catalyst loading) or cyclopentene oxide. All the catalysts are highly active in the low pressure regime and specifically at 1 bar pressure CO2. The polymerization kinetics are analysed using in situ spectroscopy and aliquot techniques: the rate law is overall second order with a first order dependence in both catalyst and epoxide concentrations and a zero order in carbon dioxide pressure. The pseudo first order rate coefficient values are compared for the catalyst series and differences are primarily attributed to effects on initiation rates. The data are consistent with a chain shuttling mechanistic hypothesis with heterodinuclear complexes showing particular rate enhancements by optimizing distinct roles in the catalytic cycles. The mechanistic hypothesis should underpin future heterodinuclear catalyst design for use both in other (co) polymerization and carbon dioxide utilization reactions.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Trott, G; Garden, JA; Williams, CK or concate me.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis and anti-influenza A virus activity of novel 2,4-disubstituted quinazoline derivatives published in 2020. Computed Properties of C7H5NO4, Reprint Addresses Cen, S; Wang, YC (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Four 2,4-disubstituted quinazoline series containing various amide moieties were designed and synthesized as new anti-influenza A virus agents using the strategies of bio-isosterism and scaffold hopping. Many of them exhibit potent in vitro anti-influenza A virus activity and low cytotoxicity (CC50: > 100 mu M). Particularly, compounds 10a5 and 17a show better activity (IC50: 3.70-4.19 mu M) and higher selective index (SI: > 27.03, > 23.87, respectively) against influenza A/WSN/33 virus (H1N1), opening a new direction for quinazoline derivatives in anti-influenza A virus field.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, MH; Zhang, GN; Wang, YJ; Wang, JX; Zhu, M; Cen, S; Wang, YC or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem