Category: 62-23-7

Recently I am researching about STEREOSELECTIVE-SYNTHESIS; CYTOTOXIC MACROLIDES; REGIOSELECTIVE-SYNTHESIS; STRUCTURAL ELUCIDATION; N-VINYLAMIDES; ENAMIDES; AMIDES; ISOMERIZATION; AMINO; CYCLIZATION, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP15H05848, JP16K05719, JP18K19079, JP18H01977, JP19K05455]; Frontier Research Base for Global Young Researchers, Osaka University, of the MEXT program; Mitsui Chemicals Award in Synthetic Organic Chemistry; Shorai Foundation for Science and Technology. Recommanded Product: 4-Nitrobenzoic acid. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Suzuki, K; Nishimoto, Y; Yasuda, M. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The reaction of alpha-(carbonylamino)allylic stannanes and alkyl halides using Et3B as a radical initiator selectively afforded (E)-enamides. A radical mechanism enables the E selectivity, which is unusual in a reaction using alpha-aminoallylic metals. In addition, this reaction system achieved a wide degree of functional group tolerance and an efficient chiral transfer reaction.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Suzuki, K; Nishimoto, Y; Yasuda, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. In 2020.0 ENVIRON SCI TECHNOL published article about ANTIBIOTIC-RESISTANCE GENES; PEPTIDYL TRANSFERASE CENTER; EASTERN CHINA; DEGRADATION; WATER; CLONING; IDENTIFICATION; METABOLISM; REDUCTION; EXPOSURE in [Liang, Bin; Wang, Aijie] Harbin Inst Technol Shenzhen, Sch Civil & Environm Engn, Shenzhen 518055, Peoples R China; [Liang, Bin; Yun, Hui; Wang, Aijie] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Biotechnol, Beijing 100085, Peoples R China; [Ma, Xiaodan; Liang, Bin; Shi, Ke; Li, Zhiling; Yan, Peisheng; Wang, Aijie] Harbin Inst Technol, Sch Environm, State Key Lab Urban Water Resource & Environm, Harbin 150090, Peoples R China; [Yun, Hui] Lanzhou Univ, Sch Life Sci, Minist Educ, Key Lab Cell Activ & Stress Adaptat, Lanzhou 730000, Peoples R China; [Guo, Yuanqiang] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China; [Guo, Yuanqiang] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China; [Liu, Shuang-Jiang] Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100101, Peoples R China in 2020.0, Cited 69.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The chlorinated nitroaromatic antibiotic chloramphenicol (CAP) is a refractory contaminant that is widely present in various environments. However, few CAP-mineralizing bacteria have been documented, and a complete CAP catabolism pathway has yet to be identified. In this study, the bacterial strain Sphingobium sp. CAP-1 was isolated from an activated sludge sample and was shown to be capable of aerobically subsisting on CAP as the sole carbon, nitrogen, and energy source while simultaneously and efficiently degrading CAP. p-Nitrobenzoic acid (PNBA), p-nitrobenzaldehyde (PNBD), protocatechuate (PCA), and the novel side chain C-3 -hydroxy-oxygenated product of CAP (O-CAP) were identified during CAP degradation. Strain CAP-1 was able to convert O-CAP to intermediate product PNBA. The putative functional genes associated with PNBA catabolism into the tricarboxylic acid cycle via PCA and floc formation were also identified by genome sequencing and comparative proteome analysis. A complete pathway for CAP catabolism was proposed. The discovery of a novel CAP oxidation/detoxification process and a complete pathway for CAP catabolism enriches the fundamental understanding of the bacterial catabolism of antibiotics, providing new insights into the microbial-mediated fate, transformation, and resistance risk of CAP in the environment. The molecular basis of CAP catabolism and floc formation in strain CAP-1 also offers theoretical guidance for the enhanced bioremediation of CAP-containing environments.

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, XD; Liang, B; Qi, MY; Yun, H; Shi, K; Li, ZL; Guo, YQ; Yan, PS; Liu, SJ; Wang, AJ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Margalef, J; Borras, C; Alegre, S; Alberico, E; Pamies, O; Dieguez, M in WILEY-V C H VERLAG GMBH published article about IRIDIUM-CATALYZED HYDROGENATION; HIGHLY ENANTIOSELECTIVE HYDROGENATION; THIOETHER-PHOSPHITE; SUBSTRATE SCOPE; RH; COMPLEXES; ENAMIDES; AMINO; PHOSPHOROAMIDITE; PHOSPHORAMIDITES in [Margalef, Jessica; Borras, Carlota; Alegre, Sabina; Pamies, Oscar; Dieguez, Montserrat] Univ Rovira & Virgili, Dept Quim Fis & Inorgan, C Marcelli Domingo 1, E-43007 Tarragona, Spain; [Alberico, Elisabetta] CNR, Ist Chim Biomol, Tr La Crucca 3, I-07100 Sassari, Italy in 2019.0, Cited 119.0. COA of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A large family of phosphite-thioether/selenoether ligands has been easily prepared from accessible L-(+)-tartaric acid and D-(+)-mannitol and applied in the M-catalyzed (M=Ir, Rh) asymmetric hydrogenation of a broad number of substrates (46 in total). Its highly modular architecture has been crucial to maximize the catalytic performance. Improving most of the reported approaches, this ligand family presents a broad substrate scope. By selecting the ligand parameters high enantioselectivities (ee’s up to 99 %) have therefore been achieved in a broad range of both, functionalized and unfunctionalized substrates. Interestingly, both enantiomers of the hydrogenation products can be usually achieved by changing the ligand parameters.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Margalef, J; Borras, C; Alegre, S; Alberico, E; Pamies, O; Dieguez, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. Lin, HZ; Qiao, YT; Yang, HY; Li, Q; Chen, Y; Qu, W; Liu, WY; Feng, F; Sun, HP in [Lin, Hongzhi; Qiao, Yuting; Yang, Hongyu; Li, Qi; Sun, Haopeng] China Pharmaceut Univ, Dept Med Chem, Nanjing 211198, Jiangsu, Peoples R China; [Feng, Feng] Jiangsu Food & Pharmaceut Sci Coll, Huaian 223003, Peoples R China; [Chen, Yao] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Jiangsu, Peoples R China; [Qu, Wei] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 211198, Jiangsu, Peoples R China; [Liu, Wenyuan] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Jiangsu, Peoples R China published Design and evaluation of Nrf2 activators with 1,3,4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells in 2020.0, Cited 35.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Oxidative stress plays vital roles in virous neurodegenerative diseases including Alzheimer’s disease. Activation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), the key regulator of oxidative stress, may provide a new therapeutic strategy for these diseases. Herein we synthesized and evaluated a series of 1,3,4-oxa/thiadiazole core Nrf2 activators as neuroprotective agents. The representative compound 8 exhibited cytoprotective and Nrf2 activation effects in a neuron-like PC-12 cells. Additionally, compound 8 showed good membrane permeability, indicating this compound could penetrate blood-brain barrier (BBB) to reach central nervous system (CNS) as a neuro-protective agent. These results indicated that these Nrf2 activators with 1,3,4-oxa/thiadiazole core could serve as a new chemotype against oxidative stress in neurodegenerative diseases.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Lin, HZ; Qiao, YT; Yang, HY; Li, Q; Chen, Y; Qu, W; Liu, WY; Feng, F; Sun, HP or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Destro, G; Loreau, O; Marcon, E; Taran, F; Cantat, T; Audisio, D in AMER CHEMICAL SOC published article about RADIOLABELED COMPOUNDS; TERMINAL ALKYNES; H BONDS; CARBOXYLATION; DISCOVERY; ACID; DECARBOXYLATION; CHEMISTRY in [Destro, Gianluca; Loreau, Olivier; Marcon, Elodie; Taran, Frederic; Audisio, Davide] Univ Paris Saclay, CEA, DRF, SCBM,JOLIOT, F-91191 Gif Sur Yvette, France; [Cantat, Thibault] Univ Paris Saclay, CNRS, CEA, NIMBE, F-91191 Gif Sur Yvette, France in 2019.0, Cited 38.0. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A copper-catalyzed procedure enabling dynamic carbon isotope exchange is described. Utilizing the universal precursor [C-14]CO2, this protocol allows to insert, in one single step, the desired carbon tag into carboxylic acids with no need of structural modifications. Reducing synthetic costs and limiting the generation of radioactive waste, this procedure will facilitate the access to carboxylic acids containing drugs and accelerate early C-14-based ADME studies supporting drug development.

Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Destro, G; Loreau, O; Marcon, E; Taran, F; Cantat, T; Audisio, D or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of various acylating agents directly from carboxylic acids WOS:000526505500001 published article about METHOXY-N-METHYLAMIDES; MANNICH-TYPE REACTION; ASYMMETRIC ALDOL REACTION; ONE-POT SYNTHESIS; WEINREB AMIDES; CONVENIENT METHOD; EFFICIENT SYNTHESIS; CONVERSION; AMINOCARBONYLATION; ACYLOXYPHOSPHONIUM in [Pilathottathil, Fathima; Kumar, Doppalapudi Vineet; Kaliyamoorthy, Alagiri] Indian Inst Sci Educ & Res, Sch Chem, Thiruvananthapuram 695551, Kerala, India in 2020, Cited 57. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A straightforward synthesis of acylating reagents such as Weinreb and MAP amides from aromatic, aliphatic carboxylic acids, and amino acids using PPh3/NBS combination is described. A chemo-selective modification of the carboxylic acid group into Weinreb amide in the presence of more reactive aldehydes and ketones is presented. All reactions were performed at ambient temperature under air using undried commercial grade solvent. Furthermore, the present methodology could be performed at a gram scale under inert-free reaction conditions. In addition, 7-azaindoline amide auxiliary (used for catalytic asymmetric aldol- and Mannich-type reactions), which behaves like Weinreb amide is also synthesized under similar reaction conditions.

SDS of cas: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Pilathottathil, F; Kumar, DV; Kaliyamoorthy, A or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Haito, A; Chatani, N in ROYAL SOC CHEMISTRY published article about SUBSTITUTED 3-METHYLENEISOINDOLIN-1-ONES; CARBONYLATION; CYCLIZATION; OXIMES; ACID in [Haito, Akira; Chatani, Naoto] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan in 2019.0, Cited 28.0. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Rh(I)-Catalyzed [3+ 2] annulation reactions of cyclopropenones with amides are reported. The reaction provides a direct approach for producing highly substituted alpha, beta-unsaturated gamma-lactam derivatives. The presence of an N(sp(2)) atom in the N-alkyl group of the amide, such as the 2-pyridinylmethyl or 8-aminoquinonyl group, is essential for the success of the reaction.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Haito, A; Chatani, N or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Air-Tolerant Direct Thiol Esterification with Carboxylic Acids Using Hydrosilane via Simple Inorganic Base Catalysis WOS:000473116200013 published article about EFFICIENT SYNTHESIS; N-ALKYLATION; SOLVENT-FREE; REDUCTIVE FUNCTIONALIZATION; KETONE SYNTHESIS; BOND FORMATION; AMINES; ALDEHYDES; ESTERS; THIOESTERS in [Xuan, Maojie; Liu, Meina] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; [Xuan, Maojie; Lu, Chunlei; Lin, Bo-Lin] ShanghaiTech Univ, SPST, Shanghai 201210, Peoples R China; [Lu, Chunlei; Lin, Bo-Lin] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China in 2019, Cited 63. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7

Direct thioesterification of carboxylic acids with thiols using nontoxic activation agents is highly desirable. Herein, an efficient and practical protocol using safe and inexpensive industrial waste polymethylhydrosiloxane as the activation agent and K3PO4 with 18-crown-6 as a catalyst is described. Various functional groups on carboxylic acid and thiol substituents can be tolerated by the present system to afford thioesters in yields of 19-100%.

Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Xuan, MJ; Lu, CL; Liu, MN; Lin, BL or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Rh(i)-Catalyzed [3+2] annulation reactions of cyclopropenones with amides published in 2019.0. Formula: C7H5NO4, Reprint Addresses Chatani, N (corresponding author), Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Rh(I)-Catalyzed [3+ 2] annulation reactions of cyclopropenones with amides are reported. The reaction provides a direct approach for producing highly substituted alpha, beta-unsaturated gamma-lactam derivatives. The presence of an N(sp(2)) atom in the N-alkyl group of the amide, such as the 2-pyridinylmethyl or 8-aminoquinonyl group, is essential for the success of the reaction.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Haito, A; Chatani, N or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article 1,3-Dibromo-5,5-dimethylhydantoin as a Precatalyst for Activation of Carbonyl Functionality WOS:000482303000091 published article about ORGANIC-COMPOUNDS; ESTERIFICATION; ALCOHOLS; HALOGENATION; POLYMERS; WATER; ACIDS in [Cebular, Klara; Bozic, Bojan D.; Stavber, Stojan] Jozef Stefan Inst, Dept Phys & Organ Chem, Jamova 39, Ljubljana 1000, Slovenia; [Cebular, Klara; Stavber, Stojan] Jozef Stefan Int Postgrad Sch, Jamova 39, Ljubljana 1000, Slovenia; [Bozic, Bojan D.] Univ Belgrade, Inst Physiol & Biochem, Fac Biol, Studentski Trg 16, Belgrade 11000, Serbia in 2019, Cited 61. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

Activation of carbonyl moiety is one of the most rudimentary approaches in organic synthesis and is crucial for a plethora of industrial-scale condensation reactions. In esterification and aldol condensation, which represent two of the most important reactions, the susceptibility of the carbonyl group to nucleophile attack allows the construction of a variety of useful organic compounds. In this context, there is a constant need for development of and improvement in the methods for addition-elimination reactions via activation of carbonyl functionality. In this paper, an advanced methodology for the direct esterification of carboxylic acids and alcohols, and for aldol condensation of aldehydes using widely available, inexpensive, and metal-free 1,3-dibromo-5,5-dimethylhydantoin under neat reaction conditions is reported. The method is air- and moisture-tolerant, allowing simple synthetic and isolation procedures for both reactions presented in this paper. The reaction pathway for esterification is proposed and a scale-up of certain industrially important derivatives is performed.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Cebular, K; Bozic, BD; Stavber, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem