Category: 62-23-7

Formula: C7H5NO4. Recently I am researching about FORMIC-ACID; COUPLING REACTIONS; PD NANOPARTICLES; FINE CHEMICALS; HYDROGENATION; HYDROGENOLYSIS; DEBENZYLATION; SELECTIVITY; FUNCTIONALIZATION; DEHYDROGENATION, Saw an article supported by the Russian Science Foundation (RSF)Russian Science Foundation (RSF) [19-13-00460]; Russian Science FoundationRussian Science Foundation (RSF) [19-13-00460] Funding Source: Russian Science Foundation. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Yakukhnov, SA; Ananikov, VP. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A highly-efficient catalytic system for hydrodebenzylation reaction is described. The cleavage of O-benzyl and N-benzyl protecting groups was performed using an uncommonly low palladium loading (0.02-0.3 mol%; TON up to 5000) in a relatively short reaction time. The approach was used for a variety of substrates including pharmaceutically important precursors, and gram-scale deprotection reaction was shown. Transfer conditions together with easy-to-make Pd/C catalyst are the key features of this debenzylation scheme.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Yakukhnov, SA; Ananikov, VP or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Regioselective microwave synthesis and derivatization of 1,5-diaryl-3-amino-1,2,4-triazoles and a study of their cholinesterase inhibition properties WOS:000474266800051 published article about SOLID-PHASE SYNTHESIS; ASSISTED SYNTHESIS; ACETYLCHOLINESTERASE; DISCOVERY; 1,2,4-TRIAZOLES; DERIVATIVES; ABSORPTION; POTENT in [Santos, Sabrina Neves; de Souza, Gabriela Alves; Pereira, Thiago Moreira; Franco, Daiana Portella; Lacerda, Renata Barbosa; Kummerle, Arthur Eugen] Univ Fed Rural Rio Janeiro, Chem Inst, Mol Divers & Med Chem Lab, Lab Diversidade Mol & Quim Med LaDMol QM, BR-23989700 Seropedica, RJ, Brazil; [Santos, Sabrina Neves; de Souza, Gabriela Alves; Pereira, Thiago Moreira; Franco, Daiana Portella; Del Cistia, Catarina de Nigris; Sant’Anna, Carlos Mauricio R.; Lacerda, Renata Barbosa; Kummerle, Arthur Eugen] Univ Fed Rural Rio Janeiro, Programa Posgrad Quim PPGQ, BR-23989700 Seropedica, RJ, Brazil in 2019.0, Cited 39.0. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Herein we describe the development of an efficient one-pot regioselective synthesis protocol to obtain N-protected or N-deprotected 1,5-diaryl-3-amino-1,2,4-triazoles from N-acyl-N-Boc-carbamidothioates. This improved protocol using microwave irradiation and low reaction times (up to 1 h) furnished desired compounds in yields ranging from 50 to 84%. This chemistry is useful for a variety of aromatic groups with electronically diverse substituents. The design and correct derivation of the amino group led to compounds able to inhibit cholinesterases with good IC50 of up to 1 mu M. Also, the mode of action (mixed-type) and SAR analysis for this series of compounds was described by means of kinetic and molecular modelling evaluations, showing potential for this class of compounds as new scaffolds for this biological activity.

SDS of cas: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Santos, SN; De Souza, GA; Pereira, TM; Franco, DP; Del Cistia, CD; Sant’Anna, CMR; Lacerda, RB; Kummerle, AE or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. Recently I am researching about HIGHLY SELECTIVE DETECTION; METAL-ORGANIC FRAMEWORKS; POLYMER NANOPARTICLES; FLUORESCENT; CHEMOSENSORS; EXPLOSIVES; EMISSION; SENSORS, Saw an article supported by the CSIRCouncil of Scientific & Industrial Research (CSIR) – India. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Makkad, SK. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A solution as well as solid state based sensor has been developed for selective detection of picric acid (PA) in water. Oligo (p-phenylenevinylene) (OPV) incorporated polystyrene nanobeads (PS-OPV-NH2) having an average size of 180 nm have been synthesized through miniemulsion polymerization. Amine (-NH2) functionalization was performed on the nanobead surface to enhance the efficiency of the sensor among a library of other nitro-organics and library of cations and anions.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Makkad, SK or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Highly Selective Synthesis of Hydrazoarenes from Nitroarenes via Polystyrene-Supported Au-Nanoparticle-Catalyzed Reduction: Application to Azoarenes, Aminoarenes, and 4,4 ‘-Diaminobiaryls WOS:000525754500058 published article about GOLD NANOPARTICLES; NITRO-COMPOUNDS; METAL NANOPARTICLES; HYDROGENATION; NITROBENZENE; OXIDATION; EFFICIENT; ALCOHOLS; ANILINE; PATHWAY in [Hong, Jee Eun; Jung, Yeonghun; Park, Youmie; Park, Yohan] Inje Univ, Coll Pharm, Gimhae 50834, Gyeongnam, South Korea; [Hong, Jee Eun; Jung, Yeonghun; Park, Youmie; Park, Yohan] Inje Univ, Inje Inst Pharmaceut Sci & Res, Gimhae 50834, Gyeongnam, South Korea in 2020, Cited 48. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A selective synthesis of hydrazoarene from nitroarene and its application are reported. Using polystyrene (PS) resins as solid supports for Au nanoparticles (AuNPs), polystyrene-supported Au nanoparticles (AuNPs@PS) were synthesized and characterized. In the presence of AuNPs@PS (1.0 mol %) as a catalyst, nitroarenes afforded corresponding hydrazoarenes (up to 99%) with high selectivity (up to 100%) under mild reaction conditions (NaBH4, 50% aq. EtOH, and room temperature). Depending on the reaction conditions (the amount of NaBH4, the substituent of nitroarenes, and the sequential addition of HCl), nitroarenes were converted to corresponding azoarenes (up to 95%), aminoarenes (up to 99%), and 4,4′-diaminobiaryls (up to 99%). Our easily recyclable catalytic system using a solid-phase reaction vessel provides an attractive synthetic method in an eco-friendly and sustainable manner.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Hong, JE; Jung, Y; Park, Y; Park, Y or concate me.. Category: phthalazines

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 62-23-7. I found the field of Chemistry very interesting. Saw the article Structure Determination of a Chloroenyne from Laurencia majuscula Using Computational Methods and Total Synthesis published in 2019.0, Reprint Addresses Burton, JW; Paton, RS (corresponding author), Univ Oxford, Dept Chem, Chem Res Lab, Mansfield Rd, Oxford OX1 3TA, England.; Kim, D (corresponding author), Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea.; Paton, RS (corresponding author), Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Despite numerous advances in spectroscopic methods through the latter part of the 20th century, the unequivocal structure determination of natural products can remain challenging, and inevitably, incorrect structures appear in the literature. Computational methods that allow the accurate prediction of NMR chemical shifts have emerged as a powerful addition to the toolbox of methods available for the structure determination of small organic molecules. Herein, we report the structure determination of a small, stereochemically rich natural product from Laurencia majuscula using the powerful combination of computational methods and total synthesis, along with the structure confirmation of notoryne, using the same approach. Additionally, we synthesized three further diastereomers of the L. majuscula enyne and have demonstrated that computations are able to distinguish each of the four synthetic diastereomers from the 32 possible diastereomers of the natural product. Key to the success of this work is to analyze the computational data to provide the greatest distinction between each diastereomer, by identifying chemical shifts that are most sensitive to changes in relative stereochemistry. The success of the computational methods in the structure determination of stereochemically rich, flexible organic molecules will allow all involved in structure determination to use these methods with confidence.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Shepherd, ED; Dyson, BS; Hak, WE; Nguyen, QNN; Lee, M; Kim, MJ; Sohn, TI; Kim, D; Burton, JW; Paton, RS or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Ayoup, MS; Fouad, MA; Abdel-Hamid, H; Ramadan, E; Abu-Serie, MM; Noby, A; Teleb, M in [Ayoup, Mohammed Salah; Fouad, Manar Ahmed; Abdel-Hamid, Hamida; Ramadan, El Sayed] Alexandria Univ, Fac Sci, Chem Dept, Alexandria 21321, Egypt; [Abu-Serie, Marwa M.] City Sci Res & Technol Applicat SRTA City, Genet Engn & Biotechnol Res Inst, Med Biotechnol Dept, Alexandria, Egypt; [Noby, Ahmed] Pharos Univ Alexandria, Fac Pharm, Dept Microbiol & Immunol, Alexandria 21311, Egypt; [Teleb, Mohamed] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt published Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis in 2020.0, Cited 84.0. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Matrix metalloproteinases (MMPs) are major modulators of the tumor microenvironment. They participate in extracellular matrix turnover, tumor growth, angiogenesis and metastasis. Accordingly, MMPs inhibition seems to be ideal solution to control cancer. Many MMPs inhibitors have been introduced ranging from hydroxamate-based peptidomimetics to the next generation non-hydroxamate inhibitors. Among MMPs, MMP-9 is attractive druggable anticancer target. Studies showed that inhibiting AKT, the central signaling node of MMP-9 upregulation, provides additional MMP-9 blockade. Furthermore, caspase-dependent AKT cleavage leads to cell death. Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential. The target adducts were designed to mimic the thematic structural features of non-hydroxamate MMP inhibitors. p-Nitrophenyl isonitrile 1 was utilized as structure entry to Ugi products with some structural similarities to amide-based caspase 3/7 activators. Besides, various acids, amines and aldehydes were employed as Ugi educts to enrich the SAR data. All adducts were screened for cytotoxicity against normal fibroblasts and three cancer cell lines; MCF-7, NFS-60 and HepG-2 utilizing MTT assay. 8,11 and 28 were more active and safer than doxorubicin with single-digit nM IC50 and promising selectivity. Mechanistically, they exhibited dual MMP-9/AKT inhibition at single-digit nM IC50 with excellent selectivity over MMP-1,-2 and -13, and induced >51% caspase 3/7 activation. Consequently, they induced >49% apoptosis as detected by flow cytometric analysis, and inhibited cell migration (metastasis) up to 97% in cancer cells. Docking simulations were nearly consistent with enzymatic evaluation, also declared possible binding modes and essential structure features of active compounds. In silico physicochemical properties, ligand efficiency and drug-likeness metrics were reasonable for all adducts. Interestingly, 8 and 28 can be considered as drug-like candidates. (C) 2019 Elsevier Masson SAS. All rights reserved.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ayoup, MS; Fouad, MA; Abdel-Hamid, H; Ramadan, E; Abu-Serie, MM; Noby, A; Teleb, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 BEILSTEIN J ORG CHEM published article about LIGANDS; HYDROGENATION; STEREOSELECTIVITY; PHOSPHINES; OXIDATION; ALCOHOLS; ACID in [Kmieciak, Anna; Krzeminski, Marek P.] Nicolaus Copernicus Univ Torun, Fac Chem, 7 Gagarin St, PL-87100 Torun, Poland in 2019.0, Cited 30.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7

New chiral regioisomeric gamma-hydroxyphosphine ligands were synthesized from alpha-pinene. The key transformation was the thermal [2,3]-sigmatropic rearrangement of allyldiphenylphosphinites, obtained from (1R,2R,4S,5R)-3-methyleneneoisoverbanol and (1R,2R,3R,5R)-4-methyleneneoisopinocampheol, to allylphosphine oxides. Hydroxy groups were introduced stereoselectively through a hydroboration-oxidation reaction proceeding from the less hindered site providing a trans relationship between the hydroxy and the phosphine substituents.

Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Kmieciak, A; Krzeminski, MP or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. Gollapalli, M; Taha, M; Javid, MT; Almandil, NB; Rahim, F; Wadood, A; Mosaddik, A; Ibrahim, M; Alqahtani, MA; Bamarouf, YA in [Gollapalli, Mohammed; Alqahtani, Mohammed A.; Bamarouf, Yasser A.] Imam Abdulrahman Bin Faisal Univ, CCSIT, POB 1982, Dammam 31441, Saudi Arabia; [Taha, Muhammad; Almandil, Noor Barak; Mosaddik, Ashik; Ibrahim, Mohamed] Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Javid, Muhammad Tariq; Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan published Synthesis of benzothiazole derivatives as a potent alpha-glucosidase inhibitor in 2019.0, Cited 44.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Diabetes is one of the pre-dominant metabolic disorders all over the world. It is the prime reason of mortality and morbidity due to hyperglycemia which is link with numerus obstacles. Delaying absorption and digestion of carbohydrate has great therapeutic impact for governing postprandial hyperglycemia. Consequently, alpha glucosidase is one of the potential therapeutic approaches that reduce absorption of glucose and delay carbohydrate digestion hence maintaining blood glucose level. In this regard we have synthesized benzothiazole based oxadiazole in search of potent anti-diabetic agent as a-glucosidase Inhibitors. Benzothiazole based oxadiazole derivatives 1-23 have been synthesized, characterized by (INMR)-I-1, (CNMR)-C-13, and MS and evaluated for alpha-glucosidase Inhibition. All analogs exhibited a varying degree of alpha-glucosidase inhibitory activity with IC50 values ranging in between 0.5 +/- 0.01-30.90 +/- 0.70 mu M when compared with the standard acarbose (IC50 = 866.30 +/- 3.20 mu M). Structure activity relationship has been established for all compounds. Molecular docking studies were performed to predict the binding interaction of the compounds with the active site of enzyme.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Gollapalli, M; Taha, M; Javid, MT; Almandil, NB; Rahim, F; Wadood, A; Mosaddik, A; Ibrahim, M; Alqahtani, MA; Bamarouf, YA or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Copper-Catalyzed Four-Component Reaction for the Synthesis of N-Difluoroethyl Imides published in 2019. HPLC of Formula: C7H5NO4, Reprint Addresses Hu, XG (corresponding author), Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China.; Hu, XG (corresponding author), Jiangxi Normal Univ, Key Lab Small Funct Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A general and efficient method for the synthesis N-difluoroethyl imides has been developed. This copper-catalyzed four-component reaction proceeds via in-situ generated difluorodiazomethane, which does not require prior formation and transferring. The reaction is scalable, tolerant toward a range of functional groups, and also suitable for the late-stage functionalization of drugs and drug-like molecules.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Gao, Y; Peng, SQ; Liu, DY; Rui, PX; Hu, XG or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Photoinduced Carbon Tetrabromide Initiated Aerobic Oxidation of Substituted Toluenes to Carboxylic Acids WOS:000509900900012 published article about C-H BONDS; BENZOIC-ACID; MOLECULAR-OXYGEN; N-HYDROXYPHTHALIMIDE; SELECTIVE OXIDATION; METAL-FREE; PHOTOOXIDATION; DERIVATIVES; COBALT; OXIDE in [Zheng, Kun; Yan, Xiaoyu; Zhang, Guofu; Yan, Xinhuan; Li, Xiaoqing; Xu, Xiangsheng] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China in 2020.0, Cited 31.0. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A mild and metal-free procedure is reported for the aerobic oxidation of substituted toluenes to carboxylic acids by using CBr (4) as initiator under irradiation from a 400 nm blue light-emitting diode.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Zheng, K; Yan, XY; Zhang, GF; Yan, XH; Li, XQ; Xu, XS or concate me.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem