Category: 62-23-7

Application In Synthesis of 4-Nitrobenzoic acid. In 2020.0 J ORG CHEM published article about TRISULFUR RADICAL-ANION; CASCADE C-S; SUBSTITUTED PHENOTHIAZINES; BOND FUNCTIONALIZATION; SULFUR; AZAPHENOTHIAZINES; CONSTRUCTION; NANOCOBALT; THIOPHENE; CELLS in [Chen, Qinghua; Xie, Rong; Jia, Huanhuan; Sun, Jialu; Lu, Guangpeng; Jiang, Huanfeng; Zhang, Min] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Sch Chem & Chem Engn, Guangzhou 510641, Peoples R China in 2020.0, Cited 64.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Herein, a new iodide-mediated three-component annulation reaction of secondary anilines, cyclohexanones, and elemental sulfur is demonstrated, which allows access to various phenothiazines with the merits of formation of multiple chemical bonds in one single operation, high step and atom efficiency, readily available feedstocks and catalyst system, and good substrate and functional group compatibility. The developed chemistry capable of constructing novel phenothiazines with structural diversity offers a significant basis for further applications.

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Reference:
Phthalazine – Wikipedia,
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Recently I am researching about CARBOXYLIC-ACIDS; BETA-CYCLODEXTRIN; CLAY NANOTUBES; SILVER NANOPARTICLES; SELECTIVE OXIDATION; GOLD NANOPARTICLES; EFFICIENT CATALYST; GREEN SYNTHESIS; ALDEHYDES; IMMOBILIZATION, Saw an article supported by the Iran Polymer and Petrochemical Institute; Alzahra University; Iran National Science Foundation (INSF)Iran National Science Foundation (INSF) [97009384]. Quality Control of 4-Nitrobenzoic acid. Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Sadjadi, S; Malmir, M; Heravi, MM. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A magnetic catalyst is synthesized through growth of dendrimer of generation 3 (G3) on the surface of halloysite (Hal) nanotubes followed by decoration of dendrimer terminal groups with ionic liquid (IL) and incorporation of Fe species. The structure of the catalyst was confirmed by using several characterization techniques. Moreover, the catalytic activity of the catalyst for oxidation of benzaldehydes to the corresponding benzoic acids in the presence of hydrogen peroxide was investigated. Notably, to improve the yield of the reaction, beta-cyclodextrin (beta-CD) was employed as phase transfer agent. The contribution of dendrimer and IL to the catalysis was confirmed by comparing the catalytic activity of the catalyst with that of control the catalysts (the catalyst without IL, Fe species and dendrimer). Furthermore, the effect of dendrimer generation was elucidated by comparing the catalytic activities of the catalysts prepared by growth of dendrimers of G1, G2 and G3 on Hal. Studying the recyclability of the catalyst, it was found that the catalyst could be recovered and recycled for several reaction times with slight loss of leaching of Fe species.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Determination of Abraham model correlations for describing solute transfer into the methyl butyrate mono-solvent at 298 K WOS:000484085600001 published article about CRYSTALLINE NONELECTROLYTE SOLUTES; CARBOXYLIC-ACID SOLUTES; EXPERIMENTAL SOLUBILITY DATA; MATHEMATICAL CORRELATION; ORGANIC-SOLVENTS; THERMOCHEMICAL BEHAVIOR; SOLUTION THERMODYNAMICS; MOLECULAR-INTERACTIONS; BINARY SOLVENTS; GAS-PHASE in [Qian, Ellen; Wadawadigi, Anisha; Zha, Olivia; Liu, Kelly; Dai, Jingyi; Eddula, Shrika; Jiang, Carina; Zhang, Alex; Zhu, Siqi; Garcia, Estefania; Acree, William E.] Univ North Texas, Dept Chem, Denton, TX 76203 USA; [Abraham, Michael H.] UCL, Dept Chem, London, England in 2020, Cited 65. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Experimental mole fraction solubilities have been determined for 27 crystalline nonelectrolyte organic compounds and for one organometallic compound (ferrocene) dissolved in methyl butyrate at 298.15 K. The crystalline compounds cover a wide range of polarity and hydrogen-bonding character. Abraham model correlations were derived by combining the solubility data measured in the current study with published values retrieved from the chemical and engineering literature. The mathematical correlations determined in the current study were found to back-calculate the observed solubility data to within standard deviations of 0.10 log units (or less).

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article A novel approach towards chemoselective reduction of nitro to amine WOS:000484876900009 published article about GOLD NANOPARTICLES; CATALYZED REDUCTION; HYDROGEN DONOR; EFFICIENT; NITROARENES; OXIDE; NICKEL; NANOCOMPOSITE; MILD; ZINC in [Dasgupta, Hridoydip Ranjan; Mukherjee, Suvodip; Ghosh, Pranab] Univ North Bengal, Dept Chem, Siliguri, W Bengal, India in 2019.0, Cited 49.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

Chemo selective reduction of a wide range of aromatic nitro compound has been performed by using inexpensive Zn powder and CuSO4 system in water medium at room temperature. This system has high tolerance to other highly reducible groups present in nitro substance along with high conversation and selectivity. This chemo-selective reduction also provides a facile root for the synthesis of other industrially important fine chemicals or biologically important compounds where other highly reducible groups are present in close proximity to the targeted nitro groups. (C) 2019 Published by Elsevier Ltd.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Dasgupta, HR; Mukherjee, S; Ghosh, P or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Name: 4-Nitrobenzoic acid. I found the field of Chemistry very interesting. Saw the article Predictable site-selective radical fluorination of tertiary ethers published in 2020.0, Reprint Addresses Xie, J (corresponding author), Nanjing Univ, BioMed Innovat Ctr,Sch Chem, State Key Lab Coordinat Chem, Jiangsu Key Lab Adv Organ Materials,Chem, Nanjing, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

In this communication, we disclose the first example of metal-free and site-selective radical fluorination of readily available tertiary alkyl ethers, enabled by synergistic photocatalysis and organocatalysis. This catalytic combination allows for exclusive fluorination of tertiary C-O bonds under mild conditions even in the presence of competing reaction sites. The excellent functional group tolerance affords valuable access to sterically hindered alkyl fluorides through late-stage modification of complex molecules. The successful use of tertiary alkyl ethers in radical fluorination enhances the structural diversity of aliphatic fluorides that can be derived from naturally abundant alcohols.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, JY; Xu, WT; Xie, J or concate me.. Computed Properties of C7H5NO4

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Cheng, WF; Chen, LY; Xu, FF; Lin, WY; Ren, XR; Li, Y in ROYAL SOC CHEMISTRY published article about DIELS-ALDER REACTIONS; MANNICH-TYPE REACTION; ENANTIOSELECTIVE CONSTRUCTION; QUATERNARY; STEREOCENTERS; 2-OXINDOLES; SCAFFOLD; BEARING; DESIGN; JOINS in [Cheng, Wen-Fu; Chen, Ling-Yan; Xu, Fang-Fang; Lin, Wei-Yu; Ren, Xinfeng; Li, Ya] Shanghai Univ Engn Sci, Coll Chem & Chem Engn, 333 Longteng Rd, Shanghai 201620, Peoples R China in 2019.0, Cited 50.0. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Organocatalytic asymmetric Michael addition between 3-substituted oxindoles and enals catalyzed by chiral camphor sulfonyl hydrazines (CaSHs) has been developed. A wide range of 3-substituted oxindoles and enals were successfully used, giving the corresponding 3,3-disubstituted oxindoles containing vicinal stereogenic carbon centers in good yields with good to excellent enantioselectivities and moderate to good diastereoselectivities (up to 89% yield, 99% ee and 99 : 1 dr).

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines. I found the field of Chemistry very interesting. Saw the article Solvent- and metal-free hydroboration of alkynes under microwave irradiation published in 2020, Reprint Addresses Rocheblave, L (corresponding author), Univ Lyon, Univ Claude Bernard Lyon 1, ISPB Fac Pharm, EA 4446,B2MC, F-69373 Lyon 08, France.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Boronic esters are versatile building blocks extensively used in organic chemistry and essential to a variety of coupling reactions. In this work, the hydroboration reactions of alkynes were performed without metal catalysts using concomitant microwave irradiation that allowed a significantly reduced reaction time. Another interesting outcome of this study was that the reaction could be carried out under solvent-free conditions, highlighting the environmentally-friendly nature of our method. A wide scope of aryl- and alkylboronic acid pinacol esters were easily synthesized from the corresponding alkynes. (C) 2020 Elsevier Ltd. All rights reserved.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Gioia, B; Arnaud, A; Radix, S; Walchshofer, N; Doleans-Jordheim, A; Rocheblave, L or concate me.

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Phthalazine – Wikipedia,
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Recently I am researching about ALIPHATIC CARBOXYLIC-ACIDS; HYDROGEN-ATOM TRANSFER; DECARBOXYLATIVE FLUORINATION; DEOXYFLUORINATION; LIGHT; ALCOHOLS; ACTIVATION, Saw an article supported by the . Published in SCIENCE PRESS in BEIJING ,Authors: Ma, JY; Xu, WT; Xie, J. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. COA of Formula: C7H5NO4

In this communication, we disclose the first example of metal-free and site-selective radical fluorination of readily available tertiary alkyl ethers, enabled by synergistic photocatalysis and organocatalysis. This catalytic combination allows for exclusive fluorination of tertiary C-O bonds under mild conditions even in the presence of competing reaction sites. The excellent functional group tolerance affords valuable access to sterically hindered alkyl fluorides through late-stage modification of complex molecules. The successful use of tertiary alkyl ethers in radical fluorination enhances the structural diversity of aliphatic fluorides that can be derived from naturally abundant alcohols.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, JY; Xu, WT; Xie, J or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Liu, Y; Zhang, JY; Feng, SY; Zhao, TL; Li, ZZ; Wang, L; Wang, PH; Du, HZ; Yuan, ST; Sun, L in [Liu, Yang; Zhao, Tingli; Wang, Lai; Du, Hongzhi; Sun, Li] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, 24 Tongjiaxiang, Nanjing, Jiangsu, Peoples R China; [Zhang, Jingyin] Southeast Univ, Dept Gynaecol & Obstet, Affiliated Zhongda Hosp, Nanjing, Jiangsu, Peoples R China; [Feng, Shuyun; Li, Zhengzheng; Yuan, Shengtao] China Pharmaceut Univ, Jiangsu Ctr Pharmacodynam Res & Evaluat, 24,Tongjiaxiang, Nanjing, Jiangsu, Peoples R China; [Wang, Puhai] Nanjing Technol Univ, Jiangsu Prov Inst Materia Med, Nanjing, Jiangsu, Peoples R China published A Novel Camptothecin Derivative 3j Inhibits NSCLC Proliferation via Induction of Cell Cycle Arrest by Topo I-Mediated DNA Damage in 2019, Cited 40. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Objective: The aim of this study is to investigate the inhibitory effect of camptothecin derivative 3j on Non-Small Cell Lung Cancer (NSCLCs) cells and the potential anti-tumor mechanisms. Background: Camptothecin compounds are considered as the third largest natural drugs which are widely investigated in the world and they suffered restriction because of serious toxicity, such as hemorrhagic cystitis and bone marrow suppression. Methods: Using cell proliferation assay and S180 tumor mice model, a series of 20(S)-O-substituted benzoyl 7-ethylcamptothecin compounds were screened and evaluated the antitumor activities in vitro and in vivo. Camptothecin derivative 3j was selected for further study using flow cytometry in NSCLCs cells. Cell cycle related protein cyclin A2, CDK2, cyclin D and cyclin E were detected by Western Blot. Then, computer molecular docking was used to confirm the interaction between 3j and Topo L Also, DNA relaxation assay and alkaline cornet assay were used to investigate the mechanism of 3j on DNA damage. Results: Our results demonstrated that camptothecin derivative 3j showed a greater antitumor effect in eleven 20(S)-O-substituted benzoyl 7-ethylcamptothecin compounds in vitro and in vivo. The IC50 of 3j was 1.54 +/- 0.41 mu M lower than irinotecan with an IC50 of 13.86 +/- 0.80 mu M in NCI-H460 cell, which was reduced by 8 fold. In NCI-H1975 cell, the IC50 of 3j was 1.87 +/- 0.23 mu M lower than irinotecan (IC50 +/- SD, 5.35 +/- 0.38 mu M), dropped by 1.8 fold. Flow cytometry analysis revealed that 3j induced significant accumulation in a dose-dependent manner. After 24h of 3j (10 mu M)treatment, the percentage of NCI-H460 cell in S-phase significantly increased (to 93.54 +/- 4.4%) compared with control cells (31.67 +/- 3.4%). Similarly, the percentage of NCI-H1975 cell in S-phase significantly increased (to 83.99 +/- 2.4%) compared with control cells (34.45 +/- 3.9%) after treatment with 10 mu M of 3j. Moreover, increased levels of cyclin A2, CDK2, and decreased levels of cyclin D, cyclin E further confirmed that cell cycle arrest was induced by 3j. Furthermore, molecular docking studies suggested that 3j interacted with Topo I-DNA and DNA-relaxation assay simultaneously confirmed that 3j suppressed the activity of Topo I. Research on the mechanism showed that 3j exhibited anti-tumour activity via activating the DNA damage response pathway and suppressing the repair pathway in NSCLC cells. Conclusion: Novel camptothecin derivative 3j has been demonstrated as a promising antitumor agent and remains to be assessed in further studies.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Liu, Y; Zhang, JY; Feng, SY; Zhao, TL; Li, ZZ; Wang, L; Wang, PH; Du, HZ; Yuan, ST; Sun, L or concate me.. Quality Control of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 ORG CHEM FRONT published article about FLUORINE; ACTIVATION; ARENES; TRIFLUOROETHYLATION; PHARMACEUTICALS; HETEROARENES in [Liu, Xiaochong; Mao, Guijie; Qiao, Jingyi; Xu, Chunzhao; Liu, Hao; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi] Heilongjiang Univ, Sch Chem & Mat Sci, Harbin 150080, Heilongjiang, Peoples R China; [Liu, Xiaochong; Qiao, Jingyi; Xu, Chunzhao; Liu, Hao; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi] Coll Heilongjiang Prov, Key Lab Chem Engn Proc & Technol High Efficiency, Harbin 150080, Heilongjiang, Peoples R China in 2019, Cited 37. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

A Ni(TFA)(2)-catalyzed ortho-trifluoromethylation of 8-aminoquinoline derivatives was developed by acyl-directed C-H functionalization. A series of 7-trifluoromethylquinolinamine derivatives were originally obtained with moderate to excellent yields by using TMSCF3 as the trifluoromethylation reagent under mild conditions. In addition, the reaction mechanism is proposed and proved by the related experiment.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem