Category: 62-23-7

I found the field of Chemistry very interesting. Saw the article Chiral terpene auxiliaries V: Synthesis of new chiral gamma-hydroxyphosphine oxides derived from alpha-pinene published in 2019.0. Application In Synthesis of 4-Nitrobenzoic acid, Reprint Addresses Krzeminski, MP (corresponding author), Nicolaus Copernicus Univ Torun, Fac Chem, 7 Gagarin St, PL-87100 Torun, Poland.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

New chiral regioisomeric gamma-hydroxyphosphine ligands were synthesized from alpha-pinene. The key transformation was the thermal [2,3]-sigmatropic rearrangement of allyldiphenylphosphinites, obtained from (1R,2R,4S,5R)-3-methyleneneoisoverbanol and (1R,2R,3R,5R)-4-methyleneneoisopinocampheol, to allylphosphine oxides. Hydroxy groups were introduced stereoselectively through a hydroboration-oxidation reaction proceeding from the less hindered site providing a trans relationship between the hydroxy and the phosphine substituents.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Kmieciak, A; Krzeminski, MP or concate me.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Enantioselective Palladium(II)-Catalyzed Oxidative Aminofluorination of Unactivated Alkenes with Et4NF.3 HF as a Fluoride Source WOS:000504784200001 published article about STRUCTURAL DIVERSITY; FLUORINATION; 3-FLUOROPIPERIDINES; NUCLEOPALLADATION; INHIBITORS; HERG in [Hou, Chuanqi; Chen, Pinhong; Liu, Guosheng] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Chinese Acad Sci, 345 Lingling Lu, Shanghai 200032, Peoples R China; [Hou, Chuanqi; Chen, Pinhong; Liu, Guosheng] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Chinese Acad Sci, Shanghai Hongkong Joint Lab Chem Synth,Ctr Excell, 345 Lingling Lu, Shanghai 200032, Peoples R China; [Liu, Guosheng] East China Normal Univ, Chang Kung Chuang Inst, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China in 2020.0, Cited 33.0. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The first asymmetric Pd-II-catalyzed aminofluorination of unactivated alkenes using chiral quinoline-oxazolines (Quox) as ligands has been developed. This reaction provides easy access to a wide array of enantiomerically enriched beta-fluoropiperidines in good yields and with excellent enantioselectivity. Notably, Et4NF.3 HF as a readily accessible nucleophilic fluoride source was found to play an essential role in the enantioselective control, and CsOCF3 also acts a key additive to improve the excellent ee value of products.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Hou, CQ; Chen, PH; Liu, GS or concate me.. Recommanded Product: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Rh(i)-Catalyzed [3+2] annulation reactions of cyclopropenones with amides published in 2019.0. Formula: C7H5NO4, Reprint Addresses Chatani, N (corresponding author), Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Rh(I)-Catalyzed [3+ 2] annulation reactions of cyclopropenones with amides are reported. The reaction provides a direct approach for producing highly substituted alpha, beta-unsaturated gamma-lactam derivatives. The presence of an N(sp(2)) atom in the N-alkyl group of the amide, such as the 2-pyridinylmethyl or 8-aminoquinonyl group, is essential for the success of the reaction.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Haito, A; Chatani, N or concate me.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. In 2019 ORG BIOMOL CHEM published article about CATALYZED REDUCTION; SOLVENT-FREE; HYDROGENATION; ALCOHOLS; EFFICIENT; ALKENES; BORANE in [Wang, Weifan; Luo, Man; Zhu, Da; Xu, Li; Ma, Mengtao] Nanjing Forestry Univ, Coll Sci, Dept Chem & Mat Sci, Nanjing 210037, Jiangsu, Peoples R China; [Yao, Weiwei] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Jiangsu, Peoples R China in 2019, Cited 47. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A catalyst-free and solvent-free method for the hydroboration of a variety of carboxylic acids with pinacolborane was developed. The hydroboration of various aromatic and aliphatic carboxylic acids as well as dicarboxylic acids with HBpin could be completed within 6 h at room temperature or within 1 h at 60 degrees C to give the products in quantitative yields under neat conditions without the need for any solvent or metal catalyst. The possible reaction mechanism was investigated in detail based on the corresponding DFT calculations and the stoichiometric reaction of acetic acid with different equivalents of HBpin (at room temperature and 0 degrees C) and it revealed the stepwise nature of the protocol.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, WF; Luo, M; Zhu, D; Yao, WW; Xu, L; Ma, MT or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Truncated Itraconazole Analogues Exhibiting Potent Anti-Hedgehog Activity and Improved Drug-like Properties WOS:000486360800008 published article about SMOOTHENED MUTATIONS; ACQUIRED-RESISTANCE; PATHWAY INHIBITOR; ANTIFUNGAL; VISMODEGIB in [Wen, Jiachen; Chennamadhavuni, Divya; Morel, Shana R.; Hadden, M. Kyle] Univ Connecticut, Dept Pharmaceut Sci, 69 North Eagleville Rd,Unit 3092, Storrs, CT 06029 USA in 2019, Cited 25. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We conducted a structure-activity relationship study to explore simplified analogues of the itraconazole (ITZ) scaffold for their ability to inhibit the hedgehog (Hh) signaling pathway. These analogues were based on exploring the effects of chemical modifications to the linker and triazolone/side chain region of ITZ. Analogue 11 was identified as the most potent compound in our first generation, with an IC50 value of 81 nM in a murine Hh-dependent basal cell carcinoma. Metabolic identification studies led us to identify truncated piperazine (26) as the major metabolite in human liver microsomes (HLMs) and an improved Hh pathway inhibitor (IC50 = 22 nM). This work verifies that continued truncation of the ITZ scaffold is a practical method to maintain potent anti-Hh activity while also reducing the molecular weight for the ITZ scaffold and achieving improved pharmacokinetic properties.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wen, JC; Chennamadhavuni, D; Morel, SR; Hadden, MK or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 CHEMCATCHEM published article about IRIDIUM-CATALYZED HYDROGENATION; HIGHLY ENANTIOSELECTIVE HYDROGENATION; THIOETHER-PHOSPHITE; SUBSTRATE SCOPE; RH; COMPLEXES; ENAMIDES; AMINO; PHOSPHOROAMIDITE; PHOSPHORAMIDITES in [Margalef, Jessica; Borras, Carlota; Alegre, Sabina; Pamies, Oscar; Dieguez, Montserrat] Univ Rovira & Virgili, Dept Quim Fis & Inorgan, C Marcelli Domingo 1, E-43007 Tarragona, Spain; [Alberico, Elisabetta] CNR, Ist Chim Biomol, Tr La Crucca 3, I-07100 Sassari, Italy in 2019.0, Cited 119.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

A large family of phosphite-thioether/selenoether ligands has been easily prepared from accessible L-(+)-tartaric acid and D-(+)-mannitol and applied in the M-catalyzed (M=Ir, Rh) asymmetric hydrogenation of a broad number of substrates (46 in total). Its highly modular architecture has been crucial to maximize the catalytic performance. Improving most of the reported approaches, this ligand family presents a broad substrate scope. By selecting the ligand parameters high enantioselectivities (ee’s up to 99 %) have therefore been achieved in a broad range of both, functionalized and unfunctionalized substrates. Interestingly, both enantiomers of the hydrogenation products can be usually achieved by changing the ligand parameters.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Margalef, J; Borras, C; Alegre, S; Alberico, E; Pamies, O; Dieguez, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Hou, CQ; Chen, PH; Liu, GS in [Hou, Chuanqi; Chen, Pinhong; Liu, Guosheng] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Chinese Acad Sci, 345 Lingling Lu, Shanghai 200032, Peoples R China; [Hou, Chuanqi; Chen, Pinhong; Liu, Guosheng] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Chinese Acad Sci, Shanghai Hongkong Joint Lab Chem Synth,Ctr Excell, 345 Lingling Lu, Shanghai 200032, Peoples R China; [Liu, Guosheng] East China Normal Univ, Chang Kung Chuang Inst, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China published Enantioselective Palladium(II)-Catalyzed Oxidative Aminofluorination of Unactivated Alkenes with Et4NF.3 HF as a Fluoride Source in 2020.0, Cited 33.0. COA of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The first asymmetric Pd-II-catalyzed aminofluorination of unactivated alkenes using chiral quinoline-oxazolines (Quox) as ligands has been developed. This reaction provides easy access to a wide array of enantiomerically enriched beta-fluoropiperidines in good yields and with excellent enantioselectivity. Notably, Et4NF.3 HF as a readily accessible nucleophilic fluoride source was found to play an essential role in the enantioselective control, and CsOCF3 also acts a key additive to improve the excellent ee value of products.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hou, CQ; Chen, PH; Liu, GS or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis WOS:000541741100027 published article about SELECTIVE-INHIBITION; GONDII; IDENTIFICATION; TRANSMISSION; ENCEPHALITIS; MECHANISM; DIAGNOSIS; INVASION; THERAPY; STRAINS in [Janetka, James W.] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA; [Barks, Jennifer; Dhason, Mary Savari; Wang, Qiuling; Sibley, L. David] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA; [Hopper, Allen T.; Yang, Ziping] Vyera Pharmaceut, New York, NY 10016 USA in 2020, Cited 56. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Calcium dependent protein kinase 1 (CDPK1) is an essential Ser/Thr kinase that controls invasion and egress by the protozoan parasite Toxoplasma gondii. The Gly gatekeeper of CDPK1 makes it exquisitely sensitive to inhibition by small molecule 1H-pyrazolo[3,4-d]pyrimidine-4-amine (PP) compounds that are bulky ATP mimetics. Here we rationally designed, synthesized, and tested a series of novel PP analogs that were evaluated for inhibition of CDPK1 enzyme activity in vitro and parasite growth in cell culture. Optimal substitution on the PP scaffold included 2-pyridyl ethers directed into the hydrophobic pocket and small carbocyclic rings accessing the ribose-binding pocket. Further optimization of the series led to identification of the lead compound 3a that displayed excellent potency, selectivity, safety profile, and efficacy in vivo. The results of these studies provide a foundation for further work to optimize CDPK1 inhibitors for the treatment of acute and chronic toxoplasmosis.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Janetka, JW; Hopper, AT; Yang, ZP; Barks, J; Dhason, MS; Wang, QL; Sibley, LD or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines. In 2019.0 TETRAHEDRON LETT published article about GOLD NANOPARTICLES; CATALYZED REDUCTION; HYDROGEN DONOR; EFFICIENT; NITROARENES; OXIDE; NICKEL; NANOCOMPOSITE; MILD; ZINC in [Dasgupta, Hridoydip Ranjan; Mukherjee, Suvodip; Ghosh, Pranab] Univ North Bengal, Dept Chem, Siliguri, W Bengal, India in 2019.0, Cited 49.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Chemo selective reduction of a wide range of aromatic nitro compound has been performed by using inexpensive Zn powder and CuSO4 system in water medium at room temperature. This system has high tolerance to other highly reducible groups present in nitro substance along with high conversation and selectivity. This chemo-selective reduction also provides a facile root for the synthesis of other industrially important fine chemicals or biologically important compounds where other highly reducible groups are present in close proximity to the targeted nitro groups. (C) 2019 Published by Elsevier Ltd.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Dasgupta, HR; Mukherjee, S; Ghosh, P or concate me.. Category: phthalazines

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Green hydroboration of carboxylic acids and mechanism investigation WOS:000465615200015 published article about CATALYZED REDUCTION; SOLVENT-FREE; HYDROGENATION; ALCOHOLS; EFFICIENT; ALKENES; BORANE in [Wang, Weifan; Luo, Man; Zhu, Da; Xu, Li; Ma, Mengtao] Nanjing Forestry Univ, Coll Sci, Dept Chem & Mat Sci, Nanjing 210037, Jiangsu, Peoples R China; [Yao, Weiwei] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Jiangsu, Peoples R China in 2019, Cited 47. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A catalyst-free and solvent-free method for the hydroboration of a variety of carboxylic acids with pinacolborane was developed. The hydroboration of various aromatic and aliphatic carboxylic acids as well as dicarboxylic acids with HBpin could be completed within 6 h at room temperature or within 1 h at 60 degrees C to give the products in quantitative yields under neat conditions without the need for any solvent or metal catalyst. The possible reaction mechanism was investigated in detail based on the corresponding DFT calculations and the stoichiometric reaction of acetic acid with different equivalents of HBpin (at room temperature and 0 degrees C) and it revealed the stepwise nature of the protocol.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, WF; Luo, M; Zhu, D; Yao, WW; Xu, L; Ma, MT or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem