Category: 62-23-7

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Combining structure- and property-based optimization to identify selective FLT3-ITD inhibitors with good antitumor efficacy in AML cell inoculated mouse xenograft model published in 2019. Computed Properties of C7H5NO4, Reprint Addresses Lu, S (corresponding author), China Pharmaceut Univ, Sch Sci, Nanjing 211198, Jiangsu, Peoples R China.; Chen, YD (corresponding author), China Pharmaceut Univ, Lab Mol Design & Drug Discovery, Nanjing 211198, Jiangsu, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

FLT3 mutation is among the most common genetic mutations in acute myeloid leukemia (AML), which is also related with poor overall survival and refractory in AML patients. Recently, FLT3 inhibitors have been approved for AML therapy. Herein, a series of new compounds with pyrazole amine scaffold was discovered, which showed potent inhibitory activity against FLT3-ITD and significant selectivity against both FLT3-ITD and AML cells expressing FLT3-ITD. Compound 46, possessing the most promising cellular activity, blocked the autophosphorylation of FLT3 pathway in MV4-11 cell line. Furthermore, the apoptosis and downregulation of P-STAT5 were also observed in tumor cells extracted from the MV411 cell xenografts model upon compound 46 treatment. Compound 46 was also metabolically stable in vitro and suppressed tumor growth significantly in MV4-11 xenografts model in vivo. Compound 46 showed no toxicity to the viscera of mice and caused no decrease in body weight of mice. In conclusion, the results of this study could provide valuable insights into discovery of new FLT3 inhibitors, and compound 46 was worthy of further development as potential drug candidate to treat AML (C) 2019 Elsevier Masson SAS. All rights reserved.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Heng, H; Wang, ZJ; Li, HM; Huang, YT; Lan, QY; Guo, XX; Zhang, L; Zhi, YL; Cai, JH; Qin, TR; Xiang, L; Wang, SX; Chen, YD; Lu, T; Lu, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. Recently I am researching about CROSS-COUPLING REACTION; NUCLEOPHILIC AROMATIC-SUBSTITUTION; PALLADIUM-CATALYZED SILYLATION; C-F ACTIVATION; ARYL FLUORIDES; GRIGNARD-REAGENTS; ALPHA-ARYLATION; POLYFLUOROARENES; BORYLATION; CLEAVAGE, Saw an article supported by the ICIQ, MINECO [CTQ2015-65496-R]; European UnionEuropean Commission [702563]; MINECO. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Liu, XW; Zarate, C; Martin, R. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The ability to selectively forge C-heteroatom bonds by C-F scission is typically accomplished by metal catalysts, specialized ligands and/or harsh reaction conditions. Described herein is a base-mediated defluorosilylation of unactivated C(sp(2))-F and C(sp(3))-F bonds that obviates the need for metal catalysts. This protocol is characterized by its simplicity, mild reaction conditions, and wide scope, even within the context of late-stage functionalization, constituting a complementary approach to existing C-Si bond-forming protocols.

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Liu, XW; Zarate, C; Martin, R or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Che, ZP; Yang, JM; Zhang, S; Sun, D; Tian, YE; Liu, SM; Lin, XM; Jiang, J; Chen, GQ in TAYLOR & FRANCIS LTD published article about ASYMMETRIC-SYNTHESIS; RESISTANCE; INHIBITORS; ALKALOIDS in [Che, Zhi-Ping; Yang, Jin-Ming; Zhang, Song; Sun, Di; Tian, Yue-E; Liu, Sheng-Ming; Lin, Xiao-Min; Jiang, Jia; Chen, Gen-Qiang] Henan Univ Sci & Technol, Coll Forestry, Dept Plant Protect, Lab Pesticidal Design & Synth, Luoyang 471023, Peoples R China in 2021, Cited 25. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Endeavor to discover biorational natural products-based insecticides, two series (27) of novel 9R/S-acyloxy derivatives of cinchonidine and cinchonine were prepared and assessed for their insecticidal activity against Mythimna separata in vivo by the leaf-dipping method at 1 mg/mL. Among all the compounds, especially derivatives 6l and 6o exhibited the best insecticidal activity with final mortality rates of 75.0% and 71.4%, respectively. Overall, a free 9-hydroxyl group is not a prerequisite for insecticidal activity and C9-substitution is well tolerated; the configuration of C8/9 position is important for insecticidal activity, and 9S-configuration is optimal; 6′-OCH3 moiety is not necessary, removal of it is also acceptable.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Che, ZP; Yang, JM; Zhang, S; Sun, D; Tian, YE; Liu, SM; Lin, XM; Jiang, J; Chen, GQ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry; Materials Science; Mineralogy very interesting. Saw the article A novel magnetic heterogeneous catalyst based on decoration of halloysite with ionic liquid-containing dendrimer published in 2019. Safety of 4-Nitrobenzoic acid, Reprint Addresses Sadjadi, S (corresponding author), Iran Polymer & Petrochem Inst, Fac Petrochem, Gas Convers Dept, POB 14975-112, Tehran, Iran.; Heravi, MM (corresponding author), Alzahra Univ, Sch Sci, Dept Chem, POB 1993891176, Tehran, Iran.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A magnetic catalyst is synthesized through growth of dendrimer of generation 3 (G3) on the surface of halloysite (Hal) nanotubes followed by decoration of dendrimer terminal groups with ionic liquid (IL) and incorporation of Fe species. The structure of the catalyst was confirmed by using several characterization techniques. Moreover, the catalytic activity of the catalyst for oxidation of benzaldehydes to the corresponding benzoic acids in the presence of hydrogen peroxide was investigated. Notably, to improve the yield of the reaction, beta-cyclodextrin (beta-CD) was employed as phase transfer agent. The contribution of dendrimer and IL to the catalysis was confirmed by comparing the catalytic activity of the catalyst with that of control the catalysts (the catalyst without IL, Fe species and dendrimer). Furthermore, the effect of dendrimer generation was elucidated by comparing the catalytic activities of the catalysts prepared by growth of dendrimers of G1, G2 and G3 on Hal. Studying the recyclability of the catalyst, it was found that the catalyst could be recovered and recycled for several reaction times with slight loss of leaching of Fe species.

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Sadjadi, S; Malmir, M; Heravi, MM or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. Recently I am researching about CARBOXYLIC-ACID SALTS; CP-H BONDS; PRIMARY ALCOHOLS; UNACTIVATED C(SP(3))-H; AEROBIC OXIDATION; WATER; AMINES; ESTERIFICATION; ALKYLATION; CONVERSION, Saw an article supported by the DST of India [DST EMR/2015/000285]; UGC, IndiaUniversity Grants Commission, India; Indian Institute of Technology Delhi; DST-FISTDepartment of Science & Technology (India); IIT D. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Dolui, P; Hazra, S; Deb, M; Elias, AJ. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Picolinamide group assisted sp(3) C-H bond oxidation of methylene groups to the corresponding carbonyl compounds has been achieved by using simple bottle ferrocene as catalyst and Cu(OAc)(2) or tert-butyl peroxybenzoate (TBPB) as oxidant under mild conditions. This method is applicable for picolinamide bound organic as well as organometallic compounds with yields in the range of 46-82%. Control experiments and mechanistic studies indicate that a radical mechanism is responsible for these oxidative transformations in which ferrocene acts as a catalyst.

SDS of cas: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Dolui, P; Hazra, S; Deb, M; Elias, AJ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 62-23-7. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis published in 2020.0, Reprint Addresses Ayoup, MS (corresponding author), Alexandria Univ, Fac Sci, Chem Dept, Alexandria 21321, Egypt.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Matrix metalloproteinases (MMPs) are major modulators of the tumor microenvironment. They participate in extracellular matrix turnover, tumor growth, angiogenesis and metastasis. Accordingly, MMPs inhibition seems to be ideal solution to control cancer. Many MMPs inhibitors have been introduced ranging from hydroxamate-based peptidomimetics to the next generation non-hydroxamate inhibitors. Among MMPs, MMP-9 is attractive druggable anticancer target. Studies showed that inhibiting AKT, the central signaling node of MMP-9 upregulation, provides additional MMP-9 blockade. Furthermore, caspase-dependent AKT cleavage leads to cell death. Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential. The target adducts were designed to mimic the thematic structural features of non-hydroxamate MMP inhibitors. p-Nitrophenyl isonitrile 1 was utilized as structure entry to Ugi products with some structural similarities to amide-based caspase 3/7 activators. Besides, various acids, amines and aldehydes were employed as Ugi educts to enrich the SAR data. All adducts were screened for cytotoxicity against normal fibroblasts and three cancer cell lines; MCF-7, NFS-60 and HepG-2 utilizing MTT assay. 8,11 and 28 were more active and safer than doxorubicin with single-digit nM IC50 and promising selectivity. Mechanistically, they exhibited dual MMP-9/AKT inhibition at single-digit nM IC50 with excellent selectivity over MMP-1,-2 and -13, and induced >51% caspase 3/7 activation. Consequently, they induced >49% apoptosis as detected by flow cytometric analysis, and inhibited cell migration (metastasis) up to 97% in cancer cells. Docking simulations were nearly consistent with enzymatic evaluation, also declared possible binding modes and essential structure features of active compounds. In silico physicochemical properties, ligand efficiency and drug-likeness metrics were reasonable for all adducts. Interestingly, 8 and 28 can be considered as drug-like candidates. (C) 2019 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ayoup, MS; Fouad, MA; Abdel-Hamid, H; Ramadan, E; Abu-Serie, MM; Noby, A; Teleb, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4-Nitrobenzoic acid. In 2019 ORG LETT published article about DE-NOVO SYNTHESIS; MICROMONOSPORA SP TU-6368; ONE-POT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; HEXASACCHARIDE FRAGMENT; SECONDARY METABOLITES; GALTAMYCIN-B; LANDOMYCIN-A; GLYCOSIDES; RIBOFURANOSYLLUMICHROME in [Mizia, J. Colin; Bennett, Clay S.] Tufts Univ, Dept Chem, Medford, MA 02155 USA in 2019, Cited 64. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The first synthesis of the pentasaccharide fragment of the angucycline antibiotic saquayamycin Z is described. By using our sulfonyl chloride mediated reagent controlled dehydrative glycosylation, we are able to assemble the glycosidic linkages with high levels of anomeric selectivity. The total synthesis was completed in 25 total steps, and in 2.5% overall yield with a longest linear sequence of 15 steps.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Mizia, JC; Bennett, CS or concate me.. Recommanded Product: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. I found the field of Chemistry very interesting. Saw the article Synthesis of novel alpha-acyloxyamides using choline chloride-based deep eutectic solvent published in 2019, Reprint Addresses Yavari, I (corresponding author), Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

The Passerini three-component reaction between acenaphthylene-1,2-dione, alkyl isocyanides, and carboxylic acids, leading to the formation of alpha-acyloxyamides in common organic solvents (CH2Cl2, MeOH) and choline chloride-based deep eutectic solvent, is described. The reaction in the latter solvent proceeded faster compared to common organic solvents. The structure of a typical product was confirmed by X-ray crystallography. [GRAPHICS] .

About 4-Nitrobenzoic acid, If you have any questions, you can contact Yavari, I; Khajeh-Khezri, A; Ghorbanzadeh, M; Halvagar, MR or concate me.. Safety of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. Recently I am researching about LIPID MEDIATOR; IDENTIFICATION; ACCESS, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP15H05904]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Morita, M; Tanabe, S; Arai, T; Kobayashi, Y. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Two trans -enynyl alcohol intermediates corresponding to the C1-C8 and C13-C22 parts of resolvin D6 (RvD6) were prepared through the Hudrlik-Peterson reaction of the TMS-substituted trans -epoxy alcohols with TMS-acetylide and subsequent TMS-desilylation. These intermediates were coupled with a 1,4-dihalo-2-butyne derivative under copper catalysis, and the resulting acetylene was reduced with Zn(Cu/Ag) to afford the TBS ether of RvD6 methyl ester. Desilylation with TBAF yielded the gamma-lactone of RvD6, which was hydrolyzed to RvD6. The total yield of RvD6 was 1.9% in 19 steps from (3-trimethylsilyl)propargyl alcohol. The TBS ether of RvE2 methyl ester was also synthesized.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Morita, M; Tanabe, S; Arai, T; Kobayashi, Y or concate me.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Raut, S; Hadi, A; Pathan, MA in WILEY published article about PHARMACOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITY; DERIVATIVES; INDAZOLE; 1,3,4-OXADIAZOLE; ANTIBACTERIAL; BEARING in [Raut, Santosh; Hadi, Abdul; Pathan, Mohd Arif] Maulana Azad Coll Arts Sci & Commerce, Dept Chem, Aurangabad, Maharashtra, India in 2020, Cited 34. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

This study presents an efficient synthesis of 3-[6-(substituted-phenyl)-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-3-yl]-1H-indazole via dehydrative condensation with cyclization of 4-amino-5-(1H-indazol-3-yl)-4H-[1,2,4]triazole-3-thiol and fluorinated or nonfluorinated carboxylic acids in presence of phosphorous oxychloride. The multistep reaction pathway proceeds through different compounds. Present synthesis has the advantages of easily accessible starting materials, convenient synthesis, simple reaction condition, wider substrate scope, and higher yield (75% to 90% isolated).

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Raut, S; Hadi, A; Pathan, MA or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem