Category: 62-23-7

Shen, SQ; Dong, LL; Lu, HZ; Dong, YH; Yang, Q; Zhang, JJ in [Shen, Shengqiang; Dong, Lili; Lu, Huizhe; Dong, Yanhong; Zhang, Jianjun] China Agr Univ, Coll Sci, Dept Pesticide Chem, Beijing, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, Shenzhen Agr Genome Res Inst, Beijing, Peoples R China published Synthesis of ureido thioglycosides as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors in 2020.0, Cited 24.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The insect beta-N-acetylhexosaminidase OfHex1 from Ostrinia furnacalis (one of the most destructive agricultural pests) has been considered as a promising pesticide target. In this study, a series of novel and readily available ureido thioglycosides were designed and synthesized based on the catalytic mechanism and the co-crystal structures of OfHex1 with substrates. After evaluation via enzyme inhibition experiments, thioglycosides 11c and 15k were found to have inhibitory activities against OfHex1 with the K-i values of 25.6 mu M and 53.8 mu M, respectively. In addition, all these ureido thioglycosides exhibited high selectivity toward OfHex1 over hOGA and HsHexB (K-i > 100 mu M). Furthermore, to investigate the inhibitory mechanism, the possible binding modes of 11c and 15k with OfHex1 were deduced based on molecular docking analysis. This work may provide useful structural starting points for further rational design of potent inhibitors of OfHex1.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Shen, SQ; Dong, LL; Lu, HZ; Dong, YH; Yang, Q; Zhang, JJ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Two-in-One Strategy for the Pd(II)-Catalyzed Tandem C-H Arylation/Decarboxylative Annulation Involved with Cyclic Diaryliodonium Salts WOS:000487577200010 published article about TRACELESS DIRECTING GROUPS; CARBOXYLIC-ACIDS; ENANTIOSELECTIVE SYNTHESIS; COUPLING REACTIONS; ORTHO-ARYLATION; BENZOIC-ACIDS; IODINE; ACTIVATION; BIARYLS; ALKYNES in [Hu, Tao; Xu, Kai; Ye, Zenghui; Zhu, Kai; Zhang, Fengzhi] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China; [Wu, Yanqi] Zhejiang Univ Technol, Inst Informat Resource, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 63.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We report here a two-in-one strategy for the Pd(II)-catalyzed tandem C-H arylation/decarboxylative annulation between readily available cyclic diaryliodonium salts and benzoic acids. The carboxylic acid functionality can be used as both a directing group for the ortho-C-H arylation and the reactive group for the tandem decarboxylative annulation. By a step-economical double cross-coupling annulation procedure, the privileged triphenylene frameworks were efficiently constructed, which have potential applications in material chemistry.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Hu, T; Xu, K; Ye, ZH; Zhu, K; Wu, YQ; Zhang, FZ or concate me.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. Recently I am researching about HYDROPHILIC INTERACTION CHROMATOGRAPHY; SILICA; ANION; SEPARATION; POLAR, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21277110]. Published in ELSEVIER in AMSTERDAM ,Authors: Wang, X; Peng, JD; Peng, HJ; Chen, J; Xian, H; Ni, RX; Li, SY; Long, DY; Zhang, ZY. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The present work describes the preparation of two ionic liquid and carboxyl acid silane reagents via photo-initiated thiol-ene click chemistry that have been bonded to silica to afford two mixed-mode stationary phases (Sil-C4Im-C9Co and Sil-C9Im-C4Co). The two stationary phases provided satisfactory retention repeatability and efficiencies. The influence of acetonitrile content, salt concentration and pH of the mobile phase was investigated to clarify the retention properties of the prepared stationary phases. The results showed that the prepared Sil-C4Im-C9Co and Sil-C9Im-C4Co undergo multiple interactions with solutes under different chromatographic conditions. The retention mechanisms were further studied by the linear energy solvation relationship and Van’t Hoff plots. Finally, the stationary phases were employed to separate hydrophobic solutes (alkylbenzenes and polycyclic aromatic hydrocarbons) under reversed phase liquid chromatography (RPLC) mode, hydrophilic solutes (carboxylic acids, nucleosides and bases) under hydrophilic interaction liquid chromatography (HILIC) mode and inorganic anions under ion-exchange chromatography (IEC) mode, providing excellent performance and varying selectivity when compared with a commercial column. The bonding method in this work is feasible and the prepared stationary phases are promising when employed in RPLC/HILIC/IEC mixed-mode chromatography applications. (C) 2019 Elsevier B.V. All rights reserved.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, X; Peng, JD; Peng, HJ; Chen, J; Xian, H; Ni, RX; Li, SY; Long, DY; Zhang, ZY or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ASIAN J ORG CHEM published article about CATALYTIC ENANTIOSELECTIVE CONSTRUCTION; UNPRECEDENTED STEREOCHEMICAL CONTROL; PRACTICAL ASYMMETRIC-SYNTHESIS; ALLYLIC ALKYLATION; NATURAL-PRODUCTS; ORGANOALUMINUM REAGENTS; CLAISEN REARRANGEMENT; STEREOGENIC CENTERS; SILYL ETHERS; THREO ALDOLS in [Hirama, Naomichi; Sakamoto, Ryu; Maruoka, Keiji] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan; [Maruoka, Keiji] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou, Guangdong, Peoples R China in 2019.0, Cited 71.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

This article describes a Lewis-acid-promoted semi-pinacol rearrangement of chiral epoxy alcohols to provide chiral beta-hydroxy aldehydes with a quaternary center at the alpha-position that are otherwise difficult to access in modern organic synthesis. The aldehydes thus obtained are highly useful synthetic intermediates, which is demonstrated by the synthesis of a serotonin antagonist.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hirama, N; Sakamoto, R; Maruoka, K or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 4-Nitrobenzoic acid. Recently I am researching about MYCOBACTERIUM-TUBERCULOSIS; CLINICAL CANDIDATE; DERIVATIVES; DISCOVERY; PYRIDINE; Q203, Saw an article supported by the Department of Science and Technology, Government of IndiaDepartment of Science & Technology (India) [GAP0584]; Council of Scientific and Industrial Research (CSIR)Council of Scientific & Industrial Research (CSIR) – India; UGC, Government of IndiaUniversity Grants Commission, India. Published in FUTURE SCI LTD in LONDON ,Authors: Makane, VB; Krishna, VS; Krishna, EV; Shukla, M; Mahizhaveni, B; Misra, S; Chopra, S; Sriram, D; Dusthackeer, VNA; Rode, HB. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Aim: In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis. Here, we are disclosing the 5-substitued 2-mercapto-1,3,4-oxadiazoles as potent antitubercular agents. Methodology: A small library of 2-mercapto-1,3,4-oxadiazoles was synthesized using various acids. The compounds were evaluated for antituberculosis activity against M. tuberculosis H37Rv. Results: Compound 8j was identified as antitubercular lead with MIC of 0.6g/ml against M. tuberculosis H37Rv. This compound was nontoxic to CHO-K1 cells and showed selectivity index of 39. Of note, 8j showed antitubercular activity against pre-extensively drug-resistant clinical isolate of Mycobacterium with MIC of 2g/ml. Conclusion: This study provides potent antitubercular agent which can be further optimized to discover novel antibiotics. [GRAPHICS] .

Application In Synthesis of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Makane, VB; Krishna, VS; Krishna, EV; Shukla, M; Mahizhaveni, B; Misra, S; Chopra, S; Sriram, D; Dusthackeer, VNA; Rode, HB or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about N-C CLEAVAGE; CARBOXYLIC-ACIDS; CATALYZED AMINOCARBONYLATION; AMINO-ACIDS; OXIDATIVE AMIDATION; FREE TRANSAMIDATION; SECONDARY AMIDES; ARYL IODIDES; METAL-FREE; ALDEHYDES, Saw an article supported by the Indiana Clinical and Translational Sciences Institute – National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award [UL1TR002529]; Indiana University-Purdue University Indianapolis (IUPUI); National Institute of Dental & Craniofacial Research grant [1R21DE029156-01]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Irving, CD; Floreancig, JT; Laulhe, S. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. HPLC of Formula: C7H5NO4

We describe a methodology for the amidation of carboxylic acids by generating phosphonium salts in situ from N-chlorophthalimide and triphenylphosphine. Aliphatic, benzylic, and aromatic carboxylic acids can be transformed into their amide counter parts using primary and secondary amines. This functional group interconversion is achieved at room temperature in good to excellent yields. Mechanistic work shows the in situ formation of chloro- and imido-phosphonium salts that react as activating agents for carboxylic acids and generate an acyloxyphosphonium species.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Irving, CD; Floreancig, JT; Laulhe, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Metal-Free Synthesis of Indolopyrans and 2,3-Dihydrofurans Based on Tandem Oxidative Cycloaddition WOS:000551552600048 published article about PICTET-SPENGLER REACTIONS; SP(3) C-H; INDOLE SYNTHESIS; IODINE(III) REAGENTS; AMINATION; EFFICIENT; FUNCTIONALIZATION; BONDS; TETRAHYDROISOQUINOLINES; ALKYLATION in [Choi, Subin; Oh, Hyeonji; Sim, Jeongwoo; Yu, Eunsoo; Park, Cheol-Min] UNIST Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea; [Shin, Seunghoon] Hanyang Univ, Dept Chem, Seoul 04763, South Korea in 2020.0, Cited 73.0. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The synthesis of versatile scaffold indolopyrans based on C-C radical-radical cross-coupling under metal-free conditions is described. The reaction involving single electron transfer between coupling partners followed by cage collapse allows highly selective cross-coupling while employing only equimolar amounts of coupling partners. Moreover, the mechanistic manifold was expanded for the functionalization of enamines to give the stereoselective synthesis of 2,3-dihydrofurans. This iodine-mediated oxidative coupling features mild conditions and fast reaction kinetics.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Choi, S; Oh, H; Sim, J; Yu, E; Shin, S; Park, CM or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Wang, MH; Zhang, GN; Wang, YJ; Wang, JX; Zhu, M; Cen, S; Wang, YC in [Wang, Minghua; Zhang, Guoning; Wang, Yujia; Wang, Juxian; Zhu, Mei; Cen, Shan; Wang, Yucheng] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China published Design, synthesis and anti-influenza A virus activity of novel 2,4-disubstituted quinazoline derivatives in 2020, Cited 28. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Four 2,4-disubstituted quinazoline series containing various amide moieties were designed and synthesized as new anti-influenza A virus agents using the strategies of bio-isosterism and scaffold hopping. Many of them exhibit potent in vitro anti-influenza A virus activity and low cytotoxicity (CC50: > 100 mu M). Particularly, compounds 10a5 and 17a show better activity (IC50: 3.70-4.19 mu M) and higher selective index (SI: > 27.03, > 23.87, respectively) against influenza A/WSN/33 virus (H1N1), opening a new direction for quinazoline derivatives in anti-influenza A virus field.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, MH; Zhang, GN; Wang, YJ; Wang, JX; Zhu, M; Cen, S; Wang, YC or concate me.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Direct Hydrofluorination of Methallyl Alkenes Using a Methanesulfonic Acid/Triethylamine Trihydrofluoride Combination WOS:000502163300099 published article about FLUORINE in [Bertrand, Xavier; Paquin, Jean-Francois] Univ Laval, Dept Chim, PROTEO, CCVC, 1045 Ave Med, Quebec City, PQ G1V 0A6, Canada in 2019.0, Cited 27.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

The use of a methanesulfonic acid/triethylamine trihydrofluoride combination for the direct hydrofluorination of methallyl-containing substrates is reported. Under those metal-free conditions that use readily available, cheap, and easy to handle reagents, a range of methallyl alkenes could be converted to their corresponding tertiary fluoride in up to 78% yield. Finally, a promising result for the adaptation of this chemistry to continuous flow conditions is reported.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Bertrand, X; Paquin, JF or concate me.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. In 2020.0 DYES PIGMENTS published article about CIS-TRANS ISOMERIZATION; REVERSIBLE PHOTOREGULATION; DNA; NANOSTRUCTURES; MOTION; PHOTOISOMERIZATION; PHOTOSWITCH; DERIVATIVES; EFFICIENT; MECHANISM in [Dudek, Marta; Pokladek, Ziemowit; Deiana, Marco; Matczyszyn, Katarzyna] Wroclaw Univ Sci & Technol, Adv Mat Engn & Modelling Grp, Wyb Wyspianskiego 27, PL-50370 Wroclaw, Poland in 2020.0, Cited 74.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Although there is much interest in the use of azobenzenes (ABs) as molecular switches for biological and material science applications, there is still need for systematic rationalization of their photophysical properties determined at both experimental and theoretical level. We present here the (re-) evaluation of the properties of some AB derivatives in the context of their geometrical substitution (para or meta) and nature of substituent effects (i.e. electron-donating groups, EDGs or electron-withdrawing groups, EWGs). Results of comprehensive experimental studies of their photophysical properties, thermal stabilities and functioning in reducing environments are rationalized by DFT calculations. As the associated n-pi* bands of the trans (E) and cis (Z) isomers of the studied ABs overlap, it is difficult to obtain high cis-to-trans conversion, however we have proved that by manipulation of the substituents position, the content of the cis isomer at the photostationary state (PSS) could be enhanced up to 30%. Moreover, we show that the presence of -NHCO- group at para positions contributes to reducing the effective bond order of the azo group resulting in the reduction of the height of the energy barrier for conversion and reduces the half-life of the cis isomer. Finally, electron deficient ABs are found to be more stable under reducing environments.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Dudek, M; Pokladek, Z; Deiana, M; Matczyszyn, K or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem