Category: 62-23-7

An article SkinEthic (TM) HCE Eye Irritation Test: Similar performance demonstrated after long distance shipment and extended storage conditions WOS:000454467300022 published article about HAZARD IDENTIFICATION; CHEMICALS; EIT in [Leblanc, Virginie; Grandidier, Marie-Helene; Cotovio, Jose; Alepee, Nathalie] LOreal Res & Innovat, 1 Ave Eugene Schueller, F-93600 Aulnay Sous Bois, France; [Yokota, Mariko] Cosmos Tech Ctr Co Ltd, NIKKOL Grp, Tokyo, Japan; [Yoshida, Daisuke; Kyoutani, Daiki] Nikoderm Res Inc, NIKKOL Grp, Osaka, Japan; [Adriaens, Els] Adriaens Consulting, Aalter, Belgium in 2019.0, Cited 16.0. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Assessment of ocular irritation risk is an international regulatory requirement in the safety evaluation of products. In response to this need, L’Oreal developed the SkinEthie Human Corneal Epithelium (HCE) Eye Irritation Test (Err) that has been included in OECD Test Guideline 492. SkinEthic (TM) HCE EIT is able to correctly and reliably identify chemicals not requiring classification versus labelling for eye irritation or serious eye damage according to UN GHS. In an effort to promote its global use, the performance of the method was evaluated after long-distance shipment and compared to European shipment conditions. Results obtained by Cosmos Technical Center (Japan) after extended tissues transit were compared to results obtained in L’Oreal (France). Thirty-nine out of 40 blinded chemicals, representing different functional chemical classes, were consistently classified in both laboratories. The SkinEthic (TM) HCE EIT test method was also evaluated for its performance after extended storage of the tissues. The performance was in agreement with the values reported in OECD TG 492, with an overall accuracy of 87.1% (based on 119 chemicals), sensitivity of 95.5% and specificity of 73.5%. The reliability and relevance of SkinEthic (TM) HCE Err test method after long-distance shipment and extended storage remain in agreement with regulatory validation criteria.

Application In Synthesis of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Leblanc, V; Yokota, M; Grandidier, MH; Yoshida, D; Adriaens, E; Cotovio, J; Kyoutani, D; Alepee, N or send Email.

Reference:
Phthalazine – Wikipedia,
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An article Palladium-Catalyzed Tandem Dehydrogenative [4+2] Annulation of Terminal Olefins with N-Sulfonyl Amides via C-H Activations WOS:000526894000073 published article about ALLYLIC ALKYLATIONS; BOND ACTIVATION; FUNCTIONALIZATION; ALLYLATION; ALKENES; ARYLATION; ACETATES; SP(3) in [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Adv Res Inst, Taizhou 318000, Peoples R China; [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Dept Chem, Taizhou 318000, Peoples R China; [Shen, Guodong] Liaocheng Univ, Sch Chem & Chem Engn, Sch Pharm, Liaocheng 252000, Shandong, Peoples R China; [Ding, Hanfeng] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China in 2020, Cited 82. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A palladium-catalyzed tandem dehydrogenative [4 + 2] annulation of terminal olefins with N-sulfonyl amides via C(sp(2))-H activation, allylic C(sp(3))-H activation, and homoallylic C(sp(3))-H elimination processes has been developed. Promoted by the DMSO ligand, various benzamides, heterocyclic arylamides, alkenyl carboxamides, and commercial olefins are found to be efficient substrates to construct important heterocyclic compounds bearing a vinyl substituent with high E stereoselectivity. Using air as the terminal oxidant also provides a great advantage regarding environmental friendliness.

Name: 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM or send Email.

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Phthalazine – Wikipedia,
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An article A nano-reactor based on PtNi@metal-organic framework composites loaded with polyoxometalates for hydrogenation-esterification tandem reactions WOS:000459580000021 published article about SELECTIVE HYDROGENATION; CATALYST; BENZOCAINE; NANOPARTICLES; PERFORMANCE; CHEMISTRY; DRIVEN; FLOW in [Kuang, Qin] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China; Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China in 2019.0, Cited 47.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Category: phthalazines

Tandem catalysis (i.e., a process in which a desirable product is synthesized by a one-step process consisting of sequential reactions) has attracted intensive attention owing to its sustainable green and atom-economical characteristics. In this process, the utilization of a high-efficiency multifunctional catalyst is key. However, different functional sites integrated within the catalyst are required to be rationally designed and precisely engineered to guarantee the synergy between the catalytic reactions. Herein, a novel kind of hydrogenation-esterification tandem catalyst with metal/acid (alloy/polyoxometalates) active sites integrated within the metal-organic frameworks (MOFs) was prepared by a facile self-sacrificial template route. In this tandem catalyst, the MOF cavities served as tandem reactors, the PtNi alloy sites encapsulated within the MOF material acted as hydrogenation sites, and the solid phosphotungstic acid embedded in the MOF cavities provided esterification sites. This well-designed tandem catalyst showed outstanding activity and selectivity towards the one-step synthesis of amino-ester-type anesthetics (e.g., benzocaine) owing to the synergistic catalysis of the metal and acid sites. Clearly, this novel tandem catalyst simplifies the traditional industry process and provides a new method to rationally construct new tandem catalysts.

Category: phthalazines. Welcome to talk about 62-23-7, If you have any questions, you can contact Chen, LN; Zhang, XB; Zhou, JH; Xie, ZX; Kuang, Q; Zheng, LS or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Structure-activity relationship studies of atpenin A5 analogs with chemical modification of the side chain moiety WOS:000464484800007 published article about INHIBITORS; HARZIANOPYRIDONE; NBRI23477; MECHANISM; POTENT in [Ohtawa, Masaki; Yano, Keisuke; Miyao, Atsuyoshi; Hiura, Tohru; Sugiyama, Kouhei; Arima, Shiho; Nagamitsu, Tohru] Kitasato Univ, Sch Pharm, Dept Synthet Nat Prod Chem, Minato Ku, 5-9-1 Shirokane, Tokyo 1088641, Japan; [Ohtawa, Masaki; Yano, Keisuke; Miyao, Atsuyoshi; Hiura, Tohru; Sugiyama, Kouhei; Arima, Shiho; Nagamitsu, Tohru] Kitasato Univ, Sch Pharm, Med Res Labs, Minato Ku, 5-9-1 Shirokane, Tokyo 1088641, Japan; [Kita, Kiyoshi] Nagasaki Univ, Sch Trop Med & Global Hlth, Nagasaki 1088641, Japan; [Omura, Satoshi] Kitasato Univ, Kitasato Inst Life Sci, Tokyo 1088641, Japan in 2019.0, Cited 18.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Category: phthalazines

We designed and synthesized new atpenin A5 analogs for SAR study. Most of the analogs lacked one or several functional groups in the side chain of atpenin A5, and the stereoisomers proved to be weak nematode complex 11 inhibitors. However, we determined that 4-epi-atpenin A5 was a potent nematode complex II inhibitor comparable to atpenin A5. Therefore, 4-epi-atpenin A5 is expected to become a new lead compound in nematicide development. (C) 2019 Elsevier Ltd. All rights reserved.

Category: phthalazines. Welcome to talk about 62-23-7, If you have any questions, you can contact Ohtawa, M; Yano, K; Miyao, A; Hiura, T; Sugiyama, K; Arima, S; Kita, K; Omura, S; Nagamitsu, T or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 ADV SYNTH CATAL published article about FORMING REDUCTIVE ELIMINATION; DIRECT ORTHO-ARYLATION; METAL-METAL BONDS; SUPPORTED PRECATALYSTS; OXIDATIVE ADDITION; PD-IV; PALLADIUM; COMPLEXES; HALIDES; ACTIVATION in [Li, Li; Song, Feifei; Wu, Yun-Dong; Zhang, Xinhao; Chen, Jiean; Huang, Yong] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Key Lab Chem Genom, Shenzhen 518055, Guangdong, Peoples R China; [Zhong, Xiumei; Zhang, Xinhao; Chen, Jiean] Shenzhen Bay Lab, Shenzhen 518055, Guangdong, Peoples R China; [Huang, Yong] Hong Kong Univ Sci Technol, Dept Chem, Kowloon, Clear Water Bay, Hong Kong, Peoples R China in 2020.0, Cited 90.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

Palladium-catalyzed cross-coupling reactions between carboxylic acids and aryl halides have several possible competitive pathways. Decarboxylative C-C bond coupling and C-H arylation are well established in the literature. However, direct C-O bond coupling between carboxylic acids and aryl halides has received little success. In this report, we describe a protocol for exclusive C-O bond formation, enabled by a bidentate N,N-ligand such as 1,10-phenanthroline. The reaction is general for a broad range of carboxylic acids and iodoarenes. Experimental evidence and computational results suggest a high energy barrier for the alternative pathway of decarboxylative carbon-carbon bond coupling.

Computed Properties of C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
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Recently I am researching about CATALYZED CARBONYLATIVE SYNTHESIS; FACILE SYNTHESIS; CYANAMIDES; INHIBITORS; POTENT; TRIPHENYLPHOSPHINE; ISOTHIOCYANATES; QUINAZOLINONES; TRANSFORMATION; LEUCETTINES, Saw an article supported by the Chiang Mai University; Thailand Research Fund through the Royal Golden Jubilee Ph.D. ProgramThailand Research Fund (TRF) [PHD/0023/2559]; Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education, Thailand. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Phakhodee, W; Yamano, D; Pattarawarapan, M. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Name: 4-Nitrobenzoic acid

A convenient ultrasound-assisted one-pot synthesis of N -acylcyanamides starting from readily available carboxylic acids and sodium cyanamide has been developed. Upon activation in the presence of trichloroisocyanuric acid (TCCA) and triphenylphosphine, a range of carboxylic acids was converted into N -acylcyanamides in good to excellent yields within 10 minutes at room temperature without base. Remarkably, N -acyl-substituted imidazolones were readily accessible through guanylation-cyclization of the in situ generated N -acylcyanamides.

Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.. Name: 4-Nitrobenzoic acid

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Heterogeneous Suzuki-Miyaura coupling of heteroaryl ester via chemoselective C(acyl)-O bond activation WOS:000471912700036 published article about CATALYZED C-O; ARYL ESTERS; NICKEL; AZOLES; SILYLATION; AMINATION; CLEAVAGE; KETONES; AMIDE in [Ma, Hongpeng; Bai, Chaolumen; Bao, Yong-Sheng] Inner Mongolia Normal Univ, Coll Chem & Environm Sci, Inner Mongolia Key Lab Green Catalysis, Hohhot 010022, Peoples R China in 2019, Cited 47. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A site-selective supported palladium nanoparticle catalyzed Suzuki-Miyaura cross-coupling reaction with heteroaryl esters and arylboronic acids as coupling partners was developed. This methodology provides a heterogeneous catalytic route for aryl ketone formation via C(acyl)-O bond activation of esters by successful suppression of the undesired decarbonylation phenomenon. The catalyst can be reused and shows high activity after eight cycles. The XPS analysis of the catalyst before and after the reaction suggested that the reaction might be performed via a Pd-0/Pd-II catalytic cycle that began with Pd-0.

Computed Properties of C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Ma, HP; Bai, CLM; Bao, YS or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity published in 2020. Formula: C7H5NO4, Reprint Addresses Jiang, C (corresponding author), China Pharmaceut Univ, Jiang Su Key Lab Drug Design & Optimizat, Tongjiaxiang 24, Nanjing 210009, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

LDH1A1, one of 19 NAD(P)(+)-dependent aldehyde dehydrogenases, participates in multiple metabolic pathways and has been indicated to play an important role in obesity and diabetes. In this study, a series of 1,3-di-methylpyrimidine-2,4-diones were designed, synthesized and evaluated as novel selective aldehyde dehy-drogenase 1A1 inhibitors. Among them, compounds 46, 50, 53, 56 and 57 exhibited excellent inhibitory activity against ALDH1A1 with IC50 values in the low nanomolar range and high selectivity over ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1. Furthermore, in vitro study demonstrated that compound 57 effectively improved glucose consumption in HepG2 cells compared to compound 1 (CM026).

Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
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Product Details of 62-23-7. Ren, DD; Xu, LB; Wang, L; Li, SS in [Ren, Didi; Xu, Lubin; Wang, Liang; Li, Shuai-Shuai] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China published Catalytic Formal Benzylic C-H Bond Functionalization of 2,5-Dialkylfuran Derivatives with Ferrocenyl Alcohols as Alkylation Reagents in 2019.0, Cited 40.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The inert benzylic C-H bond of pi-electron-rich heteroaromatic 2,5-dialkylfuran derivatives was conveniently functionalized with ferrocenyl alcohols as alkylation reagents under catalytic acidic conditions at room temperature, which features chemo- and regiospecificity, mild and metallic catalyst free conditions, and environmental benignity.

Product Details of 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Asymmetric Diels-Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors WOS:000503782700038 published article about CYCLOADDITION REACTIONS; ENANTIOSELECTIVE CYCLOADDITION; CATALYSTS; BACKBONE; DESIGN in [Ghosh, Arun K.; Grillo, Alessandro; Kovela, Satish; Brindisi, Margherita] Purdue Univ, Dept Chem, 560 Oval Dr, W Lafayette, IN 47907 USA; [Ghosh, Arun K.] Purdue Univ, Dept Med Chem & Mol Pharmacol, 560 Oval Dr, W Lafayette, IN 47907 USA; [Brindisi, Margherita] Univ Naples Federico II, Dept Excellence Pharm, Naples, Italy in 2019.0, Cited 29.0. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We describe here our investigation of the asymmetric Diels-Alder reaction of chiral 3-(acyloxy)acryloyl oxazolidinones as dienophiles in various Lewis-acid promoted reactions with cyclopentadiene. The resulting highly functionalized cycloadducts are useful intermediates for the synthesis, particularly for the optically active synthesis of 6-5-5 tricyclic hexahydro-4H-3,5-methanofuro[2,3-b]pyranol (3) with five contiguous chiral centers. This stereochemically defined crown-like heterocyclic derivative is an important high affinity ligand for a variety of highly potent HIV-1 protease inhibitors. Among the various dienophiles and Lewis acid-mediated reactions surveyed, 3-(4-methoxybenzoyl)acryloyl oxazolidinone as the dienophile and diethylaluminum chloride as the Lewis-acid provided the desired endo product with excellent diastereoselectivity. The cycloaddition was carried out in multi-gram scale and the cycloadduct was efficiently converted to alcohol 3 with high enantiomeric purity. The optically active ligand was then transformed into potent HIV-1 protease inhibitor 2.

Computed Properties of C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Ghosh, AK; Grillo, A; Kovela, S; Brindisi, M or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem