Category: 62-23-7

Formula: C7H5NO4. Xiong, J; Wei, X; Wan, YC; Ding, MW in [Xiong, Jun; Wei, Xiao; Wan, Yu-Chen; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan, Hubei, Peoples R China; [Xiong, Jun] Hubei Univ Sci & Technol, Coll Pharm, Xianning 437100, Hubei, Peoples R China published One-pot and regioselective synthesis of polysubstituted 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by sequential Ugi/Staudinger/aza-Wittig reaction in 2019.0, Cited 59.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

An efficient one-pot and regioselective synthesis of 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by Ugi/Staudinger/aza-Wittig sequence has been developed. The Ugi reactions of 2-azidobenzylamines, aldehydes, acids (or alpha-keto acids) and isocyanides produced the azide intermediates, which were then treated with tributylphosphine or triphenylphosphine to give poly-substituted 3,4-dihydroquinazolines or 4,5-dihydro-3H-1,4-benzodiazepin-3-ones in moderate to good yields by tandem Standinger/aza-Wittig reactions. (C) 2019 Elsevier Ltd. All rights reserved.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Xiong, J; Wei, X; Wan, YC; Ding, MW or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7. Nakamura, D; Sasano, Y; Iwabuchi, Y in [Nakamura, Daichi; Sasano, Yusuke; Iwabuchi, Yoshiharu] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan published Ln(OTf)(3)-catalysed highly regioselective alcoholysis of 2,3-epoxy alcohols in 2019.0, Cited 47.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Regioselectivity of Ln(OTf)(3)-catalysed alcoholysis of 2,3- and 3,4-epoxy alcohols was closely investigated to expand the scope of the transformations. The synthetic use was demonstrated by application to the construction of 4-propoxy-5-hydroxy-2,3-pentanedione (C4-propoxy-HPD), which is a potent synthetic mediator in AI-2 quorum sensing.

Welcome to talk about 62-23-7, If you have any questions, you can contact Nakamura, D; Sasano, Y; Iwabuchi, Y or send Email.. Product Details of 62-23-7

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Phthalazine – Wikipedia,
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An article Chemical Synthesis and Immunological Evaluation of a Pentasaccharide Bearing Multiple Rare Sugars as a Potential Anti-pertussis Vaccine WOS:000518166600001 published article about BORDETELLA-PERTUSSIS; CARBOHYDRATE; GLYCOSYLATION; ANTIBODIES; INDUCTION; EVOLUTION; INFECTION; BETA; CELL in [Wang, Peng; Huo, Chang-xin; Lang, Shuyao; Nick, Setare Tahmasebi; Huang, Xuefei] Michigan State Univ, Dept Chem, 578 South Shaw Lane, E Lansing, MI 48824 USA; [Caution, Kyle; Dubey, Purnima; Deora, Rajendar] Ohio State Univ, Dept Microbial Infect & Immun, 460 W 12th Ave, Columbus, OH 43210 USA; [Deora, Rajendar] Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA; [Huang, Xuefei] Michigan State Univ, Dept Biomed Engn, E Lansing, MI 48824 USA; [Huang, Xuefei] Michigan State Univ, Inst Quantitat Hlth Sci & Engn, E Lansing, MI 48824 USA in 2020, Cited 40. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

With the infection rate of Bordetella pertussis at a 60-year high, there is an urgent need for new anti-pertussis vaccines. The lipopolysaccharide (LPS) of B. pertussis is an attractive antigen for vaccine development. With the presence of multiple rare sugars and unusual glycosyl linkages, the B. pertussis LPS is a highly challenging synthetic target. In this work, aided by molecular dynamics simulation and modeling, a pertussis-LPS-like pentasaccharide was chemically synthesized for the first time. The pentasaccharide was conjugated with a powerful carrier, bacteriophage Q beta, as a vaccine candidate. Immunization of mice with the conjugate induced robust anti-glycan IgG responses with IgG titers reaching several million enzyme-linked immunosorbent assay (ELISA) units. The antibodies generated were long lasting and boostable and could recognize multiple clinical strains of B. pertussis, highlighting the potential of Q beta-glycan as a new anti-pertussis vaccine.

Recommanded Product: 4-Nitrobenzoic acid. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article 1,3,4-Thiadiazole-Containing Azo Dyes: Synthesis, Spectroscopic Properties and Molecular Structure WOS:000550229900001 published article about DERIVATIVES; 2-AMINO-1,3,4-THIADIAZOLE; THIOSEMICARBAZONES; REDUCTION in [Kudelko, Agnieszka; Olesiejuk, Monika; Luczynski, Marcin] Silesian Tech Univ, Dept Chem Organ Technol & Petrochem, Krzywoustego 4, PL-44100 Gliwice, Poland; [Swiatkowski, Marcin; Sieranski, Tomasz; Kruszynski, Rafal] Lodz Univ Technol, Inst Gen & Ecol Chem, Dept Xray Crystallog & Crystal Chem, Zeromskiego 116, PL-90924 Lodz, Poland in 2020, Cited 44. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

Three series of azo dyes derived from 2-amino-5-aryl-1,3,4-thiadiazoles and aniline,N,N-dimethylaniline and phenol were synthesized in high yields by a conventional diazotization-coupling sequence. The chemical structures of the prepared compounds were confirmed by(1)H-NMR,C-13-NMR, IR, UV-Vis spectroscopy, mass spectrometry and elemental analysis. In addition, the X-ray single crystal structure of a representative azo dye was presented. For explicit determination of the influence of a substituent on radiation absorption in UV-Vis range, time-dependent density functional theory calculations were performed.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Kudelko, A; Olesiejuk, M; Luczynski, M; Swiatkowski, M; Sieranski, T; Kruszynski, R or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, LY; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT in AMER CHEMICAL SOC published article about HISTONE DEACETYLASE INHIBITOR; ACCURATE DOCKING; IN-VITRO; GLIDE; RICOLINOSTAT; MODEL; CELL in [Shouksmith, Andrew E.; Gawel, Justyna M.; Nawar, Nabanita; Sina, Diana; Raouf, Yasir S.; Bukhari, Shazreh; He, Liying; Johns, Alexandra E.; Manaswiyoungkul, Pimyupa; Olaoye, Olasunkanmi O.; Cabral, Aaron D.; Sedighi, Abootaleb; de Araujo, Elvin D.; Gunning, Patrick T.] Univ Toronto Mississauga, Dept Chem & Phys Sci, 3359 Mississauga Rd, Mississauga, ON L5L 1C6, Canada in 2020.0, Cited 25.0. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The HDAC inhibitor 4-tert-butyl-N-(4-(hydroxycarbamoyl)phenyl)benzamide (AES-350, 51) was identified as a promising preclinical candidate for the treatment of acute myeloid leukemia (AML), an aggressive malignancy with a meagre 24% 5-year survival rate. Through screening of low-molecular-weight analogues derived from the previously discovered novel HDAC inhibitor, AES-135, compound 51 demonstrated greater HDAC isoform selectivity, higher cytotoxicity in MV4-11 cells, an improved therapeutic window, and more efficient absorption through cellular and lipid membranes. Compound 51 also demonstrated improved oral bioavailability compared to SAHA in mouse models. A broad spectrum of experiments, including FACS, ELISA, and Western blotting, were performed to support our hypothesis that 51 dose-dependently triggers apoptosis in AML cells through HDAC inhibition.

SDS of cas: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, LY; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT or send Email.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of ureido thioglycosides as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors WOS:000546631400006 published article about ACETYL-D-HEXOSAMINIDASE; CHITIN SYNTHASES; NAG-THIAZOLINE; NAPHTHALIMIDE; DERIVATIVES in [Shen, Shengqiang; Dong, Lili; Lu, Huizhe; Dong, Yanhong; Zhang, Jianjun] China Agr Univ, Coll Sci, Dept Pesticide Chem, Beijing, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, Shenzhen Agr Genome Res Inst, Beijing, Peoples R China in 2020.0, Cited 24.0. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The insect beta-N-acetylhexosaminidase OfHex1 from Ostrinia furnacalis (one of the most destructive agricultural pests) has been considered as a promising pesticide target. In this study, a series of novel and readily available ureido thioglycosides were designed and synthesized based on the catalytic mechanism and the co-crystal structures of OfHex1 with substrates. After evaluation via enzyme inhibition experiments, thioglycosides 11c and 15k were found to have inhibitory activities against OfHex1 with the K-i values of 25.6 mu M and 53.8 mu M, respectively. In addition, all these ureido thioglycosides exhibited high selectivity toward OfHex1 over hOGA and HsHexB (K-i > 100 mu M). Furthermore, to investigate the inhibitory mechanism, the possible binding modes of 11c and 15k with OfHex1 were deduced based on molecular docking analysis. This work may provide useful structural starting points for further rational design of potent inhibitors of OfHex1.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis WOS:000541741100027 published article about SELECTIVE-INHIBITION; GONDII; IDENTIFICATION; TRANSMISSION; ENCEPHALITIS; MECHANISM; DIAGNOSIS; INVASION; THERAPY; STRAINS in [Janetka, James W.] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA; [Barks, Jennifer; Dhason, Mary Savari; Wang, Qiuling; Sibley, L. David] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA; [Hopper, Allen T.; Yang, Ziping] Vyera Pharmaceut, New York, NY 10016 USA in 2020, Cited 56. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

Calcium dependent protein kinase 1 (CDPK1) is an essential Ser/Thr kinase that controls invasion and egress by the protozoan parasite Toxoplasma gondii. The Gly gatekeeper of CDPK1 makes it exquisitely sensitive to inhibition by small molecule 1H-pyrazolo[3,4-d]pyrimidine-4-amine (PP) compounds that are bulky ATP mimetics. Here we rationally designed, synthesized, and tested a series of novel PP analogs that were evaluated for inhibition of CDPK1 enzyme activity in vitro and parasite growth in cell culture. Optimal substitution on the PP scaffold included 2-pyridyl ethers directed into the hydrophobic pocket and small carbocyclic rings accessing the ribose-binding pocket. Further optimization of the series led to identification of the lead compound 3a that displayed excellent potency, selectivity, safety profile, and efficacy in vivo. The results of these studies provide a foundation for further work to optimize CDPK1 inhibitors for the treatment of acute and chronic toxoplasmosis.

Computed Properties of C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CHOLINESTERASE-INHIBITORS; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE INHIBITORS; CARBONIC-ANHYDRASE; DEMENTIA, Saw an article supported by the WissenschaftsCampus Halle WCH [W13004216]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Loesche, A; Wiemann, J; Rohmer, M; Brandt, W; Csuk, R. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Product Details of 62-23-7

The skeleton of the diterpene dehydroabietylamine was modified, and a set of 12-hydroxy-dehydroabietylamine derivatives was obtained. The compounds were screened in colorimetric Ellman’s assays to determine their ability to act as inhibitors for the enzymes acetylcholinesterase (AChE, from electric eel) and butyrylcholinesterase (BChE, from equine serum). Additional investigations concerning the enzyme kinetics were performed and showed 12-hydroxy-N-(4-nitro-benzoyl)dehydroabietylamine (13) and 12-hydroxy-N-(isonicotinoyl)dehydroabietylamine (17) as selective BChE inhibitors holding good inhibition constants K-i = 0.72 +/- 0.06 mu M and K-i = 0.86 +/- 0.19 mu M, respectively.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about MOLECULAR MOIETIES; STEPWISE REDUCTION; CHEMICAL SPACE; KALKITOXIN; (+)-KALKITOXIN; ACTIVATION; COMPLEX; DAST; BOND, Saw an article supported by the Wayne State University. Computed Properties of C7H5NO4. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Dhanju, S; Upadhyaya, K; Rice, CA; Pegan, SD; Media, J; Valeriote, FA; Crich, D. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

We describe the synthesis of 10-aza-9-oxakalkitoxin, an N,N,O-trisubstituted hydroxylamine-based analog, or hydroxalog, of the cytotoxic marine natural product kalkitoxin in which the -NMe-O- moiety replaces a -CHMe-CH2- unit in the backbone of the natural product. 10-Aza-9-oxakalkitoxin displays potent and selective cytotoxicity (IC50 2.4 ng mL(-1)) comparable to that of kalkitoxin itself (IC50 3.2 ng mL(-1)) against the human hepato-carcinoma cell line HepG2 over both the human leukemia cell line CEM and the normal hematopoietic CFU-GM. Like kalkitoxin, and contrary to the common expectation for hydroxylamines, 10-aza-9-oxakalkitoxin is not mutagenic.

Computed Properties of C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Hinzmann, A; Stricker, M; Busch, J; Glinski, S; Oike, K; Groger, H in [Hinzmann, Alessa; Stricker, Michael; Busch, Jasmin; Glinski, Sylvia; Oike, Keiko; Groeger, Harald] Bielefeld Univ, Fac Chem, Ind Organ Chem & Biotechnol, Univ Str 25, D-33615 Bielefeld, Germany published Selective TEMPO-Oxidation of Alcohols to Aldehydes in Alternative Organic Solvents in 2020.0, Cited 39.0. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The TEMPO-catalyzed oxidation of alcohols to aldehydes has emerged to one of the most widely applied methodologies for such transformations. Advantages are the utilization of sodium hypochlorite, a component of household bleach, as an oxidation agent and the use of water as a co-solvent. However, a major drawback of this method is the often occurring strict limitation to use dichloromethane as an organic solvent in a biphasic reaction medium with water. Previous studies show that dichloromethane cannot easily be substituted because a decrease of selectivity or inhibition of the reaction is observed by using alternative organic solvents. Thus, up to now, only a few examples are known in which after a tedious optimization of the reaction dichloromethane could be replaced. In order to overcome the current limitations, we were interested in finding a TEMPO-oxidation method in alternative organic solvents, which is applicable for various alcohol oxidations. As a result, we found a method for N-oxyl radical-catalyzed oxidation using sodium hypochlorite as an oxidation agent in nitriles as an organic solvent component instead of dichloromethane. Besides the oxidation of aromatic primary alcohols also aliphatic primary alcohols, secondary alcohols as well as dialcohols were successfully converted when using this method, showing high selectivity towards the carbonyl compound and low amounts of the acid side-product.

Computed Properties of C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Hinzmann, A; Stricker, M; Busch, J; Glinski, S; Oike, K; Groger, H or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem