Category: 62-23-7

Recently I am researching about ALZHEIMERS-DISEASE; OXIDATIVE STRESS; CELECOXIB; DESIGN; APOPTOSIS; ACID; MICE, Saw an article supported by the Science and Technology Planning Program of Guangzhou [201704020146]; Science and Technology Planning Program of Guangdong Province [509164523031]. Application In Synthesis of 4-Nitrobenzoic acid. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Liao, LP; Jiang, CB; Chen, JW; Shi, JG; Li, XH; Wang, Y; Wen, J; Zhou, SJ; Liang, J; Lao, YQ; Zhang, JX. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A series of 1,2,4-triazole derivatives 1-14 was synthesized to investigate their neuroprotective effects and mechanisms of action. Compounds 5-11 noticeably protected PC12 cells from the cytotoxicity of H2O2 or sodium nitroprusside (SNP). Compound 11 was the most effective derivative. Compound 11 chelated Fe (II) iron, scavenged reactive oxygen species (ROS), and restored the mitochondrial membrane potential (MMP). Moreover, it enhanced the activity of the antioxidant defense system by increasing the serum level of superoxide dismutase (SOD) and promoting the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). Compound 11 caused certain improvements in behavior, the cerebral infarction area, and serum levels of biochemical indicators (TNF-alpha, IL-10, SOD and MDA) in a rat MCAO model. The lethal dose (LD50) of compound 11 in mice receiving intraperitoneal injections was greater than 400 mg/kg. Meanwhile, pharmacokinetic experiments revealed high bioavailability of this compound after both oral and intravenous administration (F = 60.76%, CL = 0.014 mg/kg/h) and a longer half-life (4.26 and 5.11 h after oral and intravenous administration, respectively). Based on these findings, compound 11 may be a promising neuroprotectant for the treatment of ischemic stroke. (C) 2020 Elsevier Masson SAS. All rights reserved.

Application In Synthesis of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Liao, LP; Jiang, CB; Chen, JW; Shi, JG; Li, XH; Wang, Y; Wen, J; Zhou, SJ; Liang, J; Lao, YQ; Zhang, JX or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells published in 2019.0. HPLC of Formula: C7H5NO4, Reprint Addresses Pilli, RA (corresponding author), Univ Estadual Campinas, UNICAMP, Inst Chem, Dept Organ Chem, BR-13083970 Campinas, SP, Brazil.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Two series of racemic goniothalamin analogues displaying nitrogen-containing groups were designed and synthesized. A total of 19 novel analogues were evaluated against a panel of four different cancer cell lines, along with the normal prostate cell line PNT2 to determine their selectivity. Among them, goniothalamin chloroacrylamide 13 e displayed the lowest IC50 values for both MCF-7 (0.5 mu m) and PC3 (0.3 mu m) cells, about 26-fold more potent than goniothalamin (1). Besides its higher potency, compound 13 e also displayed much higher selectivity than goniothalamin. In contrast, goniothalamin isobutyramide 13 c was the most potent analogue against Caco-2 cells (IC50=0.8 mu m), about 10-fold more potent and 17-fold more selective than 1. These results reveal the potential of compounds 13 c and 13 e for further in vivo studies, representing the first goniothalamin analogues with IC50 values in the low micromolar range and high selectivity against MCF-7, Caco-2, and PC3 cancer cell lines.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Meirelles, MA; Braga, CB; Ornelas, C; Pilli, RA or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Mishra, UK; Ramesh, NG in [Mishra, Umesh K.; Ramesh, Namakkal G.] Indian Inst Technol Delhi, Dept Chem, New Delhi 110016, India published A glycal based approach to the synthesis of (+)-bulgecinine, 3-hydroxy-2,5-dihydroxymethylpyrrolidine and 2-oxapyrrolizidin-3-one in 2020.0, Cited 48.0. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A glycal based synthesis of ( + )-bulgecinine, 3-hydroxy-2,5-dihydroxymethylpyrrolidine and 2-oxapyrrolizidin-3-ones proceeding through a common intermediate is reported. The key step in the work presented here is a two-step conversion of 4,6 di-O-benzyl-D-glucal to 2,3-dideoxy-2-tosylamido-D-glucose. This manuscript reports the first carbohydrate based approach to the synthesis of ( + )-bulgecinine and the whole sequence has been accomplished with complete stereochemical integrity without the formation of mixture of products in any of these steps.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Mishra, UK; Ramesh, NG or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of 4-Nitrobenzoic acid. Recently I am researching about H AMIDATION; BOND AMIDATION; FUNCTIONALIZATION; ACTIVATION; AMINATION; 1H-INDAZOLES; COBALT(III); AZIDES; HETEROCYCLES; AZOBENZENES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773575, 81703329]; Non-profit Central Research Institute of Chinese Academy of Medical Sciences [2019-RC-HL-008]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Yang, JS; Hu, X; Liu, ZJ; Li, XY; Dong, Y; Liu, G. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A Cp*Co-III-catalyzed arene C-H bond amidation/annulation of benzamides was developed to afford quinazolinone derivatives in one-pot with high yields and broad substrate scope. This method could be applied to the synthesis of quinazolinone drugs and late-stage modification of natural products.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Yang, JS; Hu, X; Liu, ZJ; Li, XY; Dong, Y; Liu, G or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Catalytic C-H aerobic and oxidant-induced oxidation of alkylbenzenes (including toluene derivatives) over VO2+ immobilized on core-shell Fe3O4@SiO2 at room temperature in water WOS:000544674800004 published article about AQUEOUS HYDROGEN-PEROXIDE; SELECTIVE OXIDATION; BOND FUNCTIONALIZATION; SILICA; DEHYDROGENATION; ACID; BENZALDEHYDE; ACTIVATION; OXIDES; METAL in [Mohammadpour, Pegah; Safaei, Elham] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 7194684795, Iran in 2020.0, Cited 78.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7

Direct C-H bond oxidation of organic materials, and producing the necessary oxygenated compounds under mild conditions, has attracted increasing interest. The selective oxidation of various alkylbenzenes was carried out by means of a new catalyst containing VO2+ species supported on silica-coated Fe3O4 nanoparticles usingt-butyl hydroperoxide as an oxidant at room temperature in H2O or solvent-free media. The chemical and structural characterization of the catalyst using several methods such as FTIR spectroscopy, XRD, FETEM, FESEM, SAED, EDX and XPS showed that VO2+ is covalently bonded to the silica surface. High selectivity and excellent conversion of various toluene derivatives, with less reactive aliphatic (sp(3)) C-H bonds, to related benzoic acids were quite noticeable. The aerobic oxygenation reaction of these alkylbenzenes was studied under the same conditions. All the results accompanied by sustainability of the inexpensive and simple magnetically separable heterogeneous catalyst proved the important criteria for commercial applications.

Product Details of 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Mohammadpour, P; Safaei, E or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Seubert, P; Freund, M; Rudolf, R; Lin, YL; Altevogt, L; Bilitewski, U; Baro, A; Laschat, S in GEORG THIEME VERLAG KG published article about PSEUDOMONAS-AERUGINOSA; SIDEROPHORES; BIOSYNTHESIS in [Seubert, Philipp; Freund, Marcel; Rudolf, Richard; Lin, Yulin; Altevogt, Luca; Baro, Angelika; Laschat, Sabine] Univ Stuttgart, Inst Organ Chem, Pfaffenwaldring 55, D-70569 Stuttgart, Germany; [Altevogt, Luca; Bilitewski, Ursula] Helmholtz Zentrum Infekt Forsch, AG Compound Profiling & Screening, Inhoffenstr 7, D-38124 Braunschweig, Germany in 2020.0, Cited 20.0. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The reaction of 2-chloro-6,7-dimethoxy-3-nitroquinoline with a series of amines and aminoalkanoates under basic microwave-mediated conditions and under Buchwald-Hartwig amination conditions is reported. The microwave irradiation favored the reaction with amines, resulting in yields of up to 80%, whereas amino acid functionalization gave yields comparable to those of Buchwald-Hartwig amination. tert-Butyl (2R)-4-[(6,7-dimethoxy-3-nitroquinolin-2-yl)amino]-2-hydroxybutanoate was successfully cyclized to the pyoverdin chromophore, a subunit of siderophores.

SDS of cas: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Seubert, P; Freund, M; Rudolf, R; Lin, YL; Altevogt, L; Bilitewski, U; Baro, A; Laschat, S or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about SELECTIVE AEROBIC OXIDATION; HYDROGEN-PEROXIDE; ELECTRON-TRANSFER; MOLECULAR-OXYGEN; BUILDING-BLOCKS; IRON CATALYSIS; SOFT OXIDANT; ALDEHYDES; CARBON; SILICOTUNGSTATE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21871183, 21971134, 21631007, 21471087, 21225103]; Doctoral Fund of Ministry of Education of ChinaMinistry of Education, China [20130002110042]; Tsinghua University Initiative Foundation Research Program [20131089204]; State Key Laboratory of Natural and Biomimetic Drugs [K20160202]; Shanghai Institute of Technology. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Wan, Y; Wu, ZK; Yu, H; Han, S; Wei, YG. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. COA of Formula: C7H5NO4

Direct catalytic oxidation of alcohols to carboxylic acids is very attractive, but economical catalysis systems have not yet been well established. Here, we show that a pure inorganic ligand-supported chromium compound, (NH4)(3)[CrMo6O18(OH)(6)] (simplified as CrMo6), could be used to effectively promote this type of reaction in the presence of CO2. In almost all cases, oxidation of various alcohols (aromatic and aliphatic) could be achieved under mild conditions, and the corresponding carboxylic acids can be achieved in high yield. The chromium catalyst 1 can be reused several times with little loss of activity. Mechanism study and control reactions demonstrate that the acidification proceeds via the key oxidative immediate of aldehydes.

COA of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Wan, Y; Wu, ZK; Yu, H; Han, S; Wei, YG or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ANGEW CHEM INT EDIT published article about H BOND FUNCTIONALIZATION; CROSS-COUPLING REACTIONS; ALKENES; PALLADIUM; MECHANISM; OLEFINS; STYRENES; GOLD; MARKOVNIKOV; DERIVATIVES in [Ahmed, Waqar; Zhang, Sheng; Yu, Xiaoqiang; Feng, Xiujuan; Yamamoto, Yoshinori; Bao, Ming] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Peoples R China; [Ahmed, Waqar; Zhang, Sheng; Yu, Xiaoqiang; Feng, Xiujuan; Yamamoto, Yoshinori; Bao, Ming] Dalian Univ Technol, Sch Petr & Chem Engn, Panjin 124221, Peoples R China; [Yamamoto, Yoshinori] Ritsumeikan Univ, Res Org Sci & Technol, Shiga 5258577, Japan in 2019.0, Cited 75.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

The cooperative catalysis of copper, silver, and Bronsted acid is presented as a new strategy for olefin functionalization. The catalytic direct carbohydroxylation of arylalkenes with allylic alcohols provided a straightforward and efficient approach for preparing 4,5-unsaturated alcohols. Synthetically useful functional groups, such as Cl, Br, carbonyl, and chloromethyl, remained intact during the functionalization reaction.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Ahmed, W; Zhang, S; Yu, XQ; Feng, XJ; Yamamoto, Y; Bao, M or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about INTRAMOLECULAR CHARGE-TRANSFER; PICRIC ACID; PHOTOPHYSICAL PROPERTIES; LUMINESCENT MATERIALS; SELECTIVE DETECTION; SENSITIVITY; DERIVATIVES; EFFICIENT; EMISSION; MOLECULE, Saw an article supported by the Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [18-29-23045 mk]; Ministry of Education and Science of the Russian FederationMinistry of Education and Science, Russian Federation. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Verbitskiy, EV; Rusinov, GL; Chupakhin, ON; Charushin, VN. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. HPLC of Formula: C7H5NO4

Highly sensitive and selective detection of nitro containing high energy organic compounds such as picric acid (PA), 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT) has become a challenging task due to concerns over national security, criminal investigations and environment protections. Among various known detection methods, fluorescence sensors have gained special attention in recent time. The family of fluorescent sensors based on push-pull systems that incorporate nitrogen heterocycles as an electron-withdrawing group have a growing interest due to their high sensitivity, selectivity and easy tuning. The fluorescent sensors discussed in this review are classified and organized according to used azahetemcyclic scaffold, their functionality and their ability to detect of nitmaromatics by fluorescence quenching.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Verbitskiy, EV; Rusinov, GL; Chupakhin, ON; Charushin, VN or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Iron(III)-catalyzed direct synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine WOS:000472440400001 published article about SULFUR-CONTAINING POLYPEPTIDES; PEPTIDES; ACIDS in [Van Hieu Tran; Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ, Mol Imaging & Therapeut Med Res Ctr, Dept Nucl Med, Med Sch & Hosp, Jeonju 54907, South Korea; [Van Hieu Tran; Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ Hosp, Natl Univ Biomed Res Inst, Res Inst Clin Med Chonbuk, Jeonju 54907, South Korea in 2019, Cited 26. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

A highly efficient method has been developed for the synthesis of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine. Various carboxylic acids readily reacted with 2-diphenylmethoxypyridine in the presence of FeCl3 as a catalyst to provide the desired DPM esters with high yields. The procedure is facile and enables effective synthesis of a variety of esters for the protection of carboxylic acids. [GRAPHICS] .

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Tran, VH; La, MT; Kim, HK or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem