Category: 622-95-7

622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, molecular formula is C7H6BrCl, Name: 1-(Bromomethyl)-4-chlorobenzene, belongs to phthalazine compound, is a common compound. In a patnet, author is Mohamadpour, Farzaneh, once mentioned the new application about 622-95-7.

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) as a highly efficient bicyclic amidine catalyst promoted one-pot multi-component synthesis of biologically active 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aryl aldehydes and malononitrile under solvent-free conditions through simple filter with no necessity of chromatographic purification steps. Use of safe, non-volatile, non-corrosive, highly efficient, readily available and easy to handle of catalyst, one-pot reaction, high yields and short reaction times, economical and convenient synthesis, solvent-free conditions and operational simplicity are among the other added advantages that make this approach an attractive alternative for the synthesis of these biologically active compounds.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 622-95-7 help many people in the next few years. Name: 1-(Bromomethyl)-4-chlorobenzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of 1-(Bromomethyl)-4-chlorobenzene, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, molecular formula is C7H6BrCl. In an article, author is Chen, Hui,once mentioned of 622-95-7.

An efficient one-pot synthesis of spiro[indoline-3,1′-pyrazolo[1,2-b]phthalazine] derivatives via three-component reaction of phthalhydrazide, isatin, and malononitrile (cyanoacetic ester) is described. This new protocol has the advantages of high efficiency, mild reaction conditions, one-pot procedure, and convenient operation.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, molecular formula is C7H6BrCl, belongs to phthalazine compound. In a document, author is Yuan, Chunhao, introduce the new discover, Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene.

The phosphine-catalyzed [3 + 2] cycloaddition between phthalazinium dicyanomethanides and allenoates, has been achieved in dichloromethane at room temperature, providing a broad range of novel heterocyclic compounds, 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives, as single (Z)-isomers in excellent yields (88-99% yield). All reactions are operationally simple and proceed very fast under mild reaction conditions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 622-95-7. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 622-95-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, SMILES is ClC1=CC=C(CBr)C=C1, belongs to phthalazine compound. In a article, author is Zhang Haiming, introduce new discover of the category.

Synthesis and Anticonvulsant Activity Evaluation of Phthalazine and Heterocyclic Derivatives

Four series of derivatives, 6-substituted-1,2,4-triazolo[3,4-a] phthalazine derivatives and 6-substituted tetrazolo[5,1-a] phthalazine derivatives have been synthesized. The structures of compounds are confirmed by H-1 NMR, C-13 NMR, IR and HRMS. The anticonvulsant effects of the compounds are evaluated with maximal electroshock test by intraperitoneally injected in mice. The experimental results show that N-(4-bromophenyl) tetrazolo[5,1-alpha]phthalazin-6-amine (7a) was the most potent compound, with a median effective dose of 5.89 mg circle kg(-1). Its anticonvulsant effect is better than the reference drug, carbamazepine.

Application of 622-95-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 622-95-7 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 622-95-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, SMILES is ClC1=CC=C(CBr)C=C1, belongs to phthalazine compound. In a article, author is Ibrahim, Hany S., introduce new discover of the category.

Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds

RAB1 5 is a lead antibacterial agent in which trimethoprim is linked to phthalazine moiety. Similarly, our strategy in this research depends on the interconnection between some sulfa drugs and certain phthalazin-1(2H)-one scaffolds in an attempt to enhance their antibacterial activity. This approach was achieved through the combination of 4-substituted phthalazin-1(2H)-ones 9a, b or 14a, b with sulfanilamide 1a, sulfathiazole 1b or sulfadiazine 1c through amide linkers 6a, b to produce the target compounds 10a-d and 15a-e, respectively. The antibacterial activity of the newly synthesized compounds showed that all tested compounds have antibacterial activity higher than that of their reference sulfa drugs 1a-c. Compound 10c represented the highest antibacterial activity against Gram-positive bacteria Streptococcus pneumonia and Staphylococcus aureus with MIC = 0.39 mu mol/mL. Moreover, compound 10d displayed excellent antibacterial activity against Gram-negative bacteria Escherichia coli and Salmonella Lyphimurium with MIC = 0.39 and 0.78 mu mol/mL, respectively. (C) 2014 Elsevier Masson SAS. All rights reserved.

Application of 622-95-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 622-95-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem