Category: 763114-26-7

Related Products of 763114-26-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Patent£¬once mentioned of 763114-26-7

Different fumarine derivative and its preparation method and application (by machine translation)

The invention discloses a different fumarine the chemical structure of the derivative (the formula ), Through the NICD amino with aryl isocyanate, carboxylic acid, amide carbonyl chloride condensation reaction or NICD with aromatic amino through solid phosgene symmetrical amide prepared by the condensation reaction, the compound has certain in vivo and in vitro anti-cancer activity, can be used as a cancer prevention and treatment of drug application. type Formula In the chemical structure: . (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 763114-26-7. In my other articles, you can also check out more blogs about 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N750 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C16H11FN2O3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 763114-26-7, name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid. In an article£¬Which mentioned a new discovery about 763114-26-7

PHTHALAZINONE KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL USE THEREOF

A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof are described.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 763114-26-7, help many people in the next few years.Formula: C16H11FN2O3

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N766 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 763114-26-7

Compound based on ligand-CRBN induced degradation PARP-1 of ligand, as well as preparation method and application thereof (by machine translation)

The compound and the pharmaceutical composition of the CRBN compound disclosed PARP – 1 by the invention can be used for preventing, or treating a human PARP – 1 body, and E3 the compound and the cereblon pharmaceutical composition disclosed by the invention can. be used for preventing or treating a human body and having a great application prospect in, and the field of medicines / PARP – 1, PARP – 1, PARP – 1. (by machine translation)

If you are interested in 763114-26-7, you can contact me at any time and look forward to more communication. Recommanded Product: 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N778 – PubChem

Synthetic Route of 763114-26-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Patent£¬once mentioned of 763114-26-7

Simple preparation method 4 -substituted-methyl -1 – (2H) phthalazinone (by machine translation)

The invention relates to a simple preparation method. 4 -substituent methyl -1 – (2H) phthalazinone (I). The method utilizes diG substituted benzene (II) and a compound III compound in the presence of a solvent A and an alkali, and the compound, the compound of formula IV or the compound of formula IV and hydrazine hydrate are condensed to prepare 4 – (pyridin -4 – yl) methyl -1 – (2H) phthalazinone (IA) or 4 – (4 – fluoro -3 – carboxyphenyl) methyl -1 – (2H) phthalazinone (IB), respectively. The method can be used for preparing taditinib and ornisonil. The method is simple in technological process, high in reaction repeatability, easy to operate, good in product stability, and high in purity. (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 763114-26-7, and how the biochemistry of the body works.Synthetic Route of 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N759 – PubChem

Application of 763114-26-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid,introducing its new discovery.

HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a heterocyclic-imidazole derivative, a preparation method therefor, and a medical use thereof, and particularly to a new heterocyclic-imidazole derivative of general Formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof as a therapeutic agent, particularly as a poly(ADP-ribose)polymerase (PARP) inhibitor.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 763114-26-7, and how the biochemistry of the body works.Application of 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N738 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: phthalazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3

RADIOLABELLED COMPOUND

The present invention relates to radiolabelled olaparib and in particular [ 18 F]olaparib, a process for producing radiolabelled olaparib, and uses of radiolabelled olaparib in medical imaging.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, category: phthalazine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N742 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 763114-26-7

Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors

A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound 5l exhibited the most potent inhibitory effects on PARP-1 enzyme (16.10 ¡À 1.25 nM) and MDA-MB-436 cancer cell (11.62 ¡À 2.15 muM), which was close to that of Olaparib. As a PARP-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (MTDLs) for the treatment of Alzheimer?s disease (AD), the inhibitory activities of the synthesized compounds against the enzymes AChE (from electric eel) and BChE (from equine serum) were also tested. Compound 5l displayed moderate BChE inhibitory activity (9.16 ¡À 0.91 muM) which was stronger than neostigmine (12.01 ¡À 0.45 muM) and exhibited selectivity for BChE over AChE to some degree. Molecular docking studies indicated that 5l could bind simultaneously to the catalytic active of PARP-1, but it could not interact well with huBChE. For pursuit of PARP-1 and BChE dual-targeted inhibitors against AD, small and flexible non-polar groups introduced to the compound seemed to be conducive to improving its inhibitory potency on huBChE, while keeping phthalazine-1-one moiety unchanged which was mainly responsible for PARP-1 inhibitory activity. Our research gave a clue to search for new agents based on AChE and PARP-1 dual-inhibited activities to treat Alzheimer?s disease.

If you are interested in 763114-26-7, you can contact me at any time and look forward to more communication. Application In Synthesis of 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N789 – PubChem

Synthetic Route of 763114-26-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Patent£¬once mentioned of 763114-26-7

A method for preparing high-purity aurar handkerchief Nepal (by machine translation)

The invention discloses a method for preparing high-purity aurar handkerchief Nepal, is a 2-fluoro-5 – [(4-oxo -3,4-dihydrodi nitrogen phenodiazine-1-yl) methyl] benzoic acid as the starting material, is activated, aminolysis to obtain high-purity aurar handkerchief Nepal after crystallization, wherein the activation is to contain 2-fluoro-5 – [(4-oxo -3,4-dihydrodi nitrogen phenodiazine-1-yl) methyl] benzoic acid is added to a solution of carbonyl diimidazole activator, active amide intermediates made; without separation and purification of active amide intermediate, direct and 1-cyclopropanecarboxylic formyl piperazine aminolysis crystallization, aurar handkerchief Nepal prepared. The method of the invention the purity of the aurar handkerchief Nepal preparation of greater than 99.8%, the craft is simple, high yield, low cost, is more suitable for industrial production. (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 763114-26-7, and how the biochemistry of the body works.Synthetic Route of 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N776 – PubChem

Synthetic Route of 763114-26-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Article£¬once mentioned of 763114-26-7

Design, synthesis, and anticancer properties of isocorydine derivatives

Isocorydine (ICD), an aporphine alkaloid, is widely distributed in nature. Its ability to target side population (SP) cells found in human hepatocellular carcinoma (HCC) makes it and its derivative 8-amino-isocorydine (NICD) promising chemotherapeutic agents for the treatment of HCC. To improve the anticancer activity of isocorydine derivatives, twenty derivatives of NICD were designed and synthesized through chemical structure modifications of the aromatic amino group at C-8. The anti-proliferative activities of all synthesized compounds against human hepatocellular (HepG2), cervical (HeLa), and gastric (MGC-803) cancer cell lines were evaluated using an MTT assay. The results showed that all the synthetic compounds had some tumor cell growth inhibitory activity. The compound COM33 (24) was the most active with IC50 values under 10 muM (IC50 for HepG2 = 7.51 muM; IC50 for HeLa = 6.32 muM). FICD (12) and COM33 (24) were selected for further investigation of their in vitro and in vivo activities due to their relatively good antiproliferative properties. These two compounds significantly downregulated the expression of four key proteins (C-Myc, beta-Catenin, CylinD1, and Ki67) in HepG2 cells. The tumor inhibition rate of COM33 (24) in vivo was 73.8% after a dose 100 mg/kg via intraperitoneal injection and the combined inhibition rate of COM33 (24) (50 mg/kg) with sorafenib (50 mg/kg) was 66.5%. The results indicated that these isocorydine derivatives could potentially be used as targeted chemotherapy agents or could be further developed in combination with conventional chemotherapy drugs to target cancer stem cells (CSCs) and epithelial-to-mesenchymal transition (EMT), the main therapeutic targets in HCC.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 763114-26-7, and how the biochemistry of the body works.Synthetic Route of 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N798 – PubChem

Reference of 763114-26-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 763114-26-7, Name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, molecular formula is C16H11FN2O3. In a Patent£¬once mentioned of 763114-26-7

Containing the phthalazine -1 (2 H) – one structure of PARP inhibitor, its manufacturing method and medical use (by machine translation)

The invention relates to the field of pharmaceutical chemistry, and in particular relates to a class of 4 – (4 – fluoro – 3 – (1, 2, 3, 4 – tetrahydrobenz [4, 5] imidazo [1, 2 – a] pyrazine – 2 – carbonyl) benzyl) phthalazine – 1 (2 H) – ketone derivative (I), wherein R are defined in the specification, the invention also discloses a process for their preparation, and pharmaceutical compositions containing these compounds, the pharmacodynamics tests prove that, the compounds of this invention have PARP inhibitory activity, can be used as single therapeutic agents tumor, or in combination with other anti-tumor drugs, thereby improving the existing anti-tumor drug effectiveness and reduced dose and toxicity of role. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 763114-26-7. In my other articles, you can also check out more blogs about 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N782 – PubChem