Category: 763114-26-7

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 763114-26-7, molcular formula is C16H11FN2O3, introducing its new discovery. 763114-26-7

A synthesis method of aurar handkerchief nepal (by machine translation)

The invention discloses a method for synthesizing aurar handkerchief nepal, the method uses phthalic hydrazide as the starting material, phosphorus oxychloride is generated by the reaction with 1 – chloro – 4 – carbonyl phthalazine, then with 2 – fluoro – 5 – bromomethyl benzoic acid ethyl ester produced by the reaction of 2 – fluoro – 5 – [(4 – oxo – 3, 4 – […] – 1 – yl) methyl] benzoic acid ethyl ester; then hydrolysis, by acylation, with 1 – (cyclopropyl-carbonyl) – piperazine condensation reaction produced aurar handkerchief nepal. Synthetic method of this invention for the first time in order to phthalic hydrazide as the starting material, easily available raw materials, environmental protection; and uses Neigishi coupling, using organic metal reaction, avoid the use of the higher cost of the son naphthol borane, to switch to the zinc powder, the production cost is reduced, the route to reach the total yield 70.2%. The invention synthetic method of reaction route is relatively short, mild reaction conditions, is suitable for industrial mass production. (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 763114-26-7, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N760 – PubChem

763114-26-7, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 763114-26-7, name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, introducing its new discovery.

PARP – 1 and Tankyrase1/2 multi-target inhibitor, its preparation and its use (by machine translation)

The invention relates to the field of pharmaceutical chemistry, in particular relates to a containing phthalazine – 1 (2 H) – one structure of PARP – 1 and tankyrase1/2 multi-target inhibitor (I), processes for their preparation, and pharmaceutical compositions containing these compounds and their use of anti-tumor. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.763114-26-7, you can also check out more blogs about763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N781 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 763114-26-7, name is 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, introducing its new discovery. 763114-26-7

A micro-channel modular reaction device for continuously preparing aurar handkerchief nepal intermediates (by machine translation)

The present invention discloses a micro-channel aurar handkerchief nepal modular reaction device for the continuous production of the intermediates, including 3 – hydroxy isobenzofuran – 1 (3 H) – ketone and dimethyl methylene chloride solution of dichloromethane solution in the micro-reactor in the 1st reaction, liquid obtained by (3 – oxo – 1, 3 – ISO-benzofuran – 1 – yl) dimethyl phosphate effluent; then with 2 – fluoro – 5 – formyl phenyl nitrile dichloromethane solution of triethylamine in methylene chloride solution and 2nd micro-reactor to react to generate 2 – fluoro – 5 – (3 – oxo – 3 H – isobenzofuran – 1 – yl methylene) reaction of the nitrile; finally the reaction liquid with the ethanol solution of sodium hydroxide is obtained by stirring with hydrazine hydrate of homogeneous mixed solution in the micro-reactor in the 3rd reaction, processing effluent to obtain the aurar handkerchief nepal intermediate 2 – fluoro – 5 – [(4 – oxo – 3, 4 – dihydrodi diazonaphthalene – 1 – yl) methyl] benzoic acid. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.763114-26-7, you can also check out more blogs about763114-26-7

Reference£º
Phthalazine – Wikipedia,
Phthalazine | C8H6N743 – PubChem

A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, cas is 763114-26-7,the phthalazine compound. An updated downstream synthesis route of 763114-26-7 as follows. 763114-26-7

A solution of 1-5 – [(3,4-dihydro-4-oxo-l-phthalazinyl) methyl] -2- fluorobenzoic acid (60.0 g, 0.20 mol)Suspended in 600 mL of acetonitrile,Anhydrous piperazine (43.0 g, 0.50 mol)Piperazine dihydrochloride (79.0 g, 0.50 mol)Concentrated sulfuric acid (2.78 ml, 0.04 mol)Heated to 78-80 C under reflux for 7 to 8 hours,Drop to room temperature,Concentrated under reduced pressure acetonitrile, water was added 1000ml, stirred for 30min; concentrated ammonia was added dropwise to a PH value of 7-8, stirred 2h, suction filtration,44.1 g of 1- [5 – [(3,4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] piperazine was obtained in a yield of 60.1%.1- [5 – [(3,4-dihydro-4-oxo-1-phthalazin-yl) methyl] -2-fluorobenzoyl] piperazine 1H NMR, (400 MHz) see Figure 1.

763114-26-7, A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 763114-26-7, you can also browse my other articles.

Reference£º
Patent; Shanghai Pharmaceutical Group Co., Ltd.; Deng Yu; (7 pag.)CN106554316; (2017); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

763114-26-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, cas is 763114-26-7,the phthalazine compound, it is a common compound, a new synthetic route is introduced below.

A solution of 1-5 – [(3,4-dihydro-4-oxo-l-phthalazinyl) methyl] -2- fluorobenzoic acid (60.0 g, 0.20 mol)Suspended in 600 mL of acetonitrile,Anhydrous piperazine (43.0 g, 0.50 mol)Piperazine dihydrochloride (79.0 g, 0.50 mol)Concentrated sulfuric acid (2.78 ml, 0.04 mol)Heated to 78-80 C under reflux for 7 to 8 hours,Drop to room temperature,Concentrated under reduced pressure acetonitrile, water was added 1000ml, stirred for 30min; concentrated ammonia was added dropwise to a PH value of 7-8, stirred 2h, suction filtration,44.1 g of 1- [5 – [(3,4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] piperazine was obtained in a yield of 60.1%.1- [5 – [(3,4-dihydro-4-oxo-1-phthalazin-yl) methyl] -2-fluorobenzoyl] piperazine 1H NMR, (400 MHz) see Figure 1.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 763114-26-7, 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Reference£º
Patent; Shanghai Pharmaceutical Group Co., Ltd.; Deng Yu; (7 pag.)CN106554316; (2017); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

As a common heterocyclic compound, it belong phthalazine compound,2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid,763114-26-7,Molecular formula: C16H11FN2O3,mainly used in chemical industry, its synthesis route is as follows.,763114-26-7

A solution of 1-5 – [(3,4-dihydro-4-oxo-l-phthalazinyl) methyl] -2- fluorobenzoic acid (60.0 g, 0.20 mol)Suspended in 600 mL of acetonitrile,Anhydrous piperazine (43.0 g, 0.50 mol)Piperazine dihydrochloride (79.0 g, 0.50 mol)Concentrated sulfuric acid (2.78 ml, 0.04 mol)Heated to 78-80 C under reflux for 7 to 8 hours,Drop to room temperature,Concentrated under reduced pressure acetonitrile, water was added 1000ml, stirred for 30min; concentrated ammonia was added dropwise to a PH value of 7-8, stirred 2h, suction filtration,44.1 g of 1- [5 – [(3,4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] piperazine was obtained in a yield of 60.1%.1- [5 – [(3,4-dihydro-4-oxo-1-phthalazin-yl) methyl] -2-fluorobenzoyl] piperazine 1H NMR, (400 MHz) see Figure 1.

With the synthetic route has been constantly updated, we look forward to future research findings about 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid,belong phthalazine compound

Reference£º
Patent; Shanghai Pharmaceutical Group Co., Ltd.; Deng Yu; (7 pag.)CN106554316; (2017); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem

763114-26-7, 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid is a phthalazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,763114-26-7

A solution of 1-5 – [(3,4-dihydro-4-oxo-l-phthalazinyl) methyl] -2- fluorobenzoic acid (60.0 g, 0.20 mol)Suspended in 600 mL of acetonitrile,Anhydrous piperazine (43.0 g, 0.50 mol)Piperazine dihydrochloride (79.0 g, 0.50 mol)Concentrated sulfuric acid (2.78 ml, 0.04 mol)Heated to 78-80 C under reflux for 7 to 8 hours,Drop to room temperature,Concentrated under reduced pressure acetonitrile, water was added 1000ml, stirred for 30min; concentrated ammonia was added dropwise to a PH value of 7-8, stirred 2h, suction filtration,44.1 g of 1- [5 – [(3,4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] piperazine was obtained in a yield of 60.1%.1- [5 – [(3,4-dihydro-4-oxo-1-phthalazin-yl) methyl] -2-fluorobenzoyl] piperazine 1H NMR, (400 MHz) see Figure 1.

As the paragraph descriping shows that 763114-26-7 is playing an increasingly important role.

Reference£º
Patent; Shanghai Pharmaceutical Group Co., Ltd.; Deng Yu; (7 pag.)CN106554316; (2017); A;,
Phthalazine – Wikipedia
Phthalazine | C8H6N2 – PubChem