Category: 767-00-0

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 767-00-0, Name is 4-Hydroxybenzonitrile, molecular formula is C7H5NO. In an article, author is Behalo, Mohamed S.,once mentioned of 767-00-0, Recommanded Product: 4-Hydroxybenzonitrile.

One-pot synthesis of 1,3,4-oxadiazole derivatives was achieved by treatment of 2-((4-(phenoxathiin-2-yl) phthalazin-1-yl)oxy) acetohydrazide with aromatic aldehydes in the presence of cerium(IV) ammonium nitrate in dichloromethane. This facile method was confirmed by the cyclization-oxidation reaction of the corresponding hydrazone by cerium(IV) ammonium nitrate to afford the same 1,3,4-oxadiazoles. Also, the reaction of 2-((4-(phenoxathiin-2-yl)phthalazin-1-yl) oxy) acetohydrazide with aromatic carboxylic acids in the presence of cerium(IV) ammonium nitrate in polyethylene glycol afforded 1,3,4-oxadiazole derivatives. The structural formulae of all products were confirmed and characterized by elemental analyses and spectral data. Most of the synthesized products were evaluated for their antibacterial and antifungal activities and showed potent to weak activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 767-00-0, Name is 4-Hydroxybenzonitrile, molecular formula is C7H5NO. In an article, author is Mohamadpour, Farzaneh,once mentioned of 767-00-0, Formula: https://www.ambeed.com/products/767-00-0.html.

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU): as a highly efficient bicyclic amidine catalyst promoted solvent-free and one-pot synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5,10-dione derivatives

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) as a highly efficient bicyclic amidine catalyst promoted one-pot multi-component synthesis of biologically active 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aryl aldehydes and malononitrile under solvent-free conditions through simple filter with no necessity of chromatographic purification steps. Use of safe, non-volatile, non-corrosive, highly efficient, readily available and easy to handle of catalyst, one-pot reaction, high yields and short reaction times, economical and convenient synthesis, solvent-free conditions and operational simplicity are among the other added advantages that make this approach an attractive alternative for the synthesis of these biologically active compounds.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 767-00-0, you can contact me at any time and look forward to more communication. Formula: https://www.ambeed.com/products/767-00-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is El-Shamy, Ibrahim E., once mentioned the application of 767-00-0, Name: 4-Hydroxybenzonitrile, Name is 4-Hydroxybenzonitrile, molecular formula is C7H5NO, molecular weight is 119.12, MDL number is MFCD00002312, category is phthalazine. Now introduce a scientific discovery about this category.

Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxo-phthalazin-2yl] acetic acid hydrazide derivatives

The phthalazine carbohydrazide 2 was prepared and incorporated into the corresponding 1,2,4-triazole and carbamate derivatives. Phthalazine carboxylic acid hydrazide 2 was treated with isatine and cyclohexanone to give the corresponding hydrazone derivatives 16,19 in good yields. Furthermore, cc-amino acid derivative conjugated with 1-oxophthalazine moiety 35 was synthesized by the reaction of the corresponding aizde 28, via the azide-coupling method, with glycine methyl ester. The peptide ester 35 was converted into their corresponding amide 36 by treating with methanolic ammonia. Moreover, 35 was boiled with hydrazine hydrate to afford the corresponding hydrazide 37. Finally, the dipeptide 38 was prepared by coupling of 35 with L-alanine methyl ester. Some of these compounds were screened in vitro for their antimicrobial activity. The energy gap between the highest occupied molecular orbital and lowest unoccupied molecular orbital has been calculated using the theoretical computations to reflect the chemical reactivity and kinetic stability of compounds. (C) 2014 Elsevier Ltd. All rights reserved.

If you are interested in 767-00-0, you can contact me at any time and look forward to more communication. Name: 4-Hydroxybenzonitrile.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Recommanded Product: 4-Hydroxybenzonitrile, begins with the direct observation of nature— in this case, of matter.767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazine compound. In a document, author is Ghorbani-Vaghei, Ramin, introduce the new discover.

One-pot synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives under solvent-free conditions

A series of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones were obtained from aldehydes, phthalhydrazide and malononitrile in good to excellent yields at 80-100 degrees C under solvent-free conditions by proceeding through a simple, mild and efficient procedure utilizing N, N, N’, N’-tetrabromobenzene-1,3-disulfonamide [TBBDA] and poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) [PBBS] as catalysts.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 767-00-0. Recommanded Product: 4-Hydroxybenzonitrile.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazine compound. In a document, author is Zhu, Mingfei, introduce the new discover, Formula: C7H5NO.

L-4, a Well-Tolerated and Orally Active Inhibitor of Hedgehog Pathway, Exhibited Potent Anti-tumor Effects Against Medulloblastoma in vitro and in vivo

Inhibition of aberrant Hedgehog (Hh) pathway had been proved to be a promising therapeutic intervention in cancers like basal cell carcinoma (BCC), medulloblastoma (MB), and so on. Two drugs (Vismodegib, Sonidegib) were approved to treat BCC and more inhibitors are in clinical investigation. However, the adverse effects and drug resistance restricted the use of Hh inhibitors. In the present study, 61 synthesized compounds containing central backbone of phthalazine or dimethylpyridazine were screened as candidates of new Hh signaling inhibitors by performing dual luciferase reporter assay. Among the compounds, L-4 exhibited an IC50 value of 2.33 nM in the Shh-Light II assay. L-4 strongly inhibited the Hh pathway in vitro and blocked the Hh pathway by antagonizing the smoothened receptor (Smo). Remarkably, L-4 could significantly suppress the Hh pathway activity provoked by Smo mutant (D473H) which showed strong resistant properties to existing drugs such as Vismodegib. Orally administered L-4 exhibited prominent dose-dependent anti-tumor efficacy in vivo in Ptch+/-; p53-/- MB allograft model. Furthermore, L-4 showed good tolerance in acute toxicity test using ICR mice. These evidences indicated that L-4 was a potent, well-tolerated, orally active inhibitor of Hedgehog pathway, and might be a promising candidate in development of Hh-targeted anti-cancer drugs.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 767-00-0 is helpful to your research. Formula: C7H5NO.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, Name: 4-Hydroxybenzonitrile, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 767-00-0, Name is 4-Hydroxybenzonitrile, molecular formula is C7H5NO, belongs to phthalazine compound. In a document, author is Chalaki, Samaneh B..

Cu-II Anchored onto the Magnetic Talc: A New Magnetic Nanostructured Catalyst for the One-Pot Gram-Scale Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione Derivatives

In the present study Cu(II)anchored onto the magnetic talc (gamma-Fe2O3/ talc /Cu(II)NPs) was successfully synthesized and characterized by FT-IR, XRD, TEM, FE-SEM, EDX, VSM, and ICP-OES techniques. Structural characterizations reveal that the gamma-Fe2O3/talc/Cu(II)NPs are superparamagnetic in nature, structured as a composite with average diameter of about 19-31 nm. The prepared nanostructured catalyst efficiently catalyzed the preparation of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones at the gram scale without the use of the toxic organic solvents. The magnetically separable and environmentally friendly nanostructured catalyst remains quite stable during reaction conditions and reused for at least five recycle runs.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 767-00-0, in my other articles. Name: 4-Hydroxybenzonitrile.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem