Category: 767-00-0

Let¡¯s face it, organic chemistry can seem difficult to learn, Product Details of 767-00-0, Especially from a beginner¡¯s point of view. Like 767-00-0, Name is 4-Hydroxybenzonitrile, molecular formula is phthalazines, belongs to phthalazines compound. In a document, author is Yunta, Maria J. R., introducing its new discovery.

Tropical and Subtropical Parasitic Diseases: Targets for a New Approach to Virtual Screening

Computational techniques are widely used to reduce costs associated with new drug development with the ability to bind a specific molecular target. These studies need a Brookhaven protein data bank structure sample of the enzyme interaction with an inhibitor of adequate size. In this context, a new computational methodology is postulated to be used when there are no published samples fulfilling this requirements. In this study, 7 compounds, which showed anti-T. cruzi, L. donovani and L. infantum properties, and proved to be inhibitors of their Fe-SOD enzymes, have been theoretically evaluated against related parasites Fe-SOD enzymes, which have been proposed as targets for antiparasitic drugs. This methodology may be applied to similar cases and also to generate starting structures to be used with different CADD methods

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 767-00-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazines compound. In a article, author is Rha, Chang Joo, introduce new discover of the category.

An effective phthalazine-imidazole-based chemosensor for detecting Cu2+, Co2+ and S2- via the color change

A novel and effective phthalazine-imidazole-based colorimetric chemosensor (E)-1-(2-((1H-imidazol-2-yl)me-thylene)hydrazinyl)phthalazine NNI was synthesized and tested to detect Cu2+ or Co2+ ions in buffer solution. NNI could probe Cu2+ and Co2+ by the color change from colorless to yellow. The complexation stoichiometries of NNI toward Cu2+ and Co2+ were, respectively, confirmed to be as 1:1 ratio and 2:1 by results of Job plot and ESI-mass. Detection limits of NNI for each metal showed 0.12 mu M and 65 nM which are lower than WHO guideline (31.5 mu M for Cu2+) and US Environmental Protection Agency (EPA) guideline (1.7 mu M for Co2+). Quantification of NNI for each metal was successful in real water samples. The Cu2+-NNI complex could detect S2- by demetallation with color change from yellow to colorless, and detection limit for S2- was determined as 0.80 mu M, which is lower than WHO guideline (14.8 mu M). Cu2+-NNI could detect S2- without interference when other anions coexisted. Detection of Cu2+, Co2+ and S2- among various metal ions and anions was successfully confirmed using test papers stained with NNI and Cu2+-NNI. Sensing processes of Cu2+, Co2+ and S2- by NNI were elucidated by UV-vis titration, ESI-mass, FT-IR, H-1 NMR titration and DFT calculations.

Synthetic Route of 767-00-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 767-00-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 767-00-0, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazines compound. In a article, author is Kour, Manmeet, introduce new discover of the category.

Ionic liquid coated sulfonated carbon@titania composites for the one-pot synthesis of indeno[1,2-b]indole-9,10-diones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in aqueous media

A highly active and stable ionic liquid based novel solid Bronsted acid catalyst (C@TiO2-SO3H-ILs) was prepared by coating a long chain ionic liquid onto sulfonated carbon@titania composites. The ionic liquid coating resulted in efficient stability and activity of C@TiO2-SO3H-ILs under aqueous conditions by creating a hydrophobic environment on the catalyst surface. The catalytic activity of the newly designed catalyst was tested in the one-pot multicomponent synthesis of indeno[1,2-b]indole-9,10-diones and 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in aqueous media. The structure of the most active catalyst, C@TiO2-SO3H-IL1, before and after the coating with the ionic liquid was investigated by FTIR, TGA, XRD, CHNS, EDX, SEM and HRTEM. The catalyst allows easy recovery and excellent reusability for up to five catalytic runs without considerable loss of activity.

Application of 767-00-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 767-00-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 767-00-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazines compound. In a article, author is Azarifar, Ali, introduce new discover of the category.

Nano-ZnO: an efficient and reusable catalyst for one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and pyrazolo[1,2-a][1,2,4]triazole-1,3-diones

The catalytic activity of nano-structured ZnO has been explored in the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione and pyrazolo[1,2-a][1,2,4]triazole-1,3-dione derivatives via a three-component coupling reaction between aromatic aldehydes, malononitrile, and phthalhydrazides or 4-arylurazoles, respectively. High yield, low reaction times, non-toxicity and recyclability of the catalyst, and easy work-up are the main merits of this protocol.

Synthetic Route of 767-00-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 767-00-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 767-00-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 767-00-0, Name is 4-Hydroxybenzonitrile, SMILES is OC1=CC=C(C=C1)C#N, belongs to phthalazines compound. In a article, author is Cui, Zhi-Ming, introduce new discover of the category.

Simple Analogues of Quaternary Benzo[c]phenanthridine Alkaloids: Discovery of a Novel Antifungal 2-Phenylphthalazin-2-ium Scaffold with Excellent Potency against Phytopathogenic Fungi

Inspired by sanguinarine and chelerythrine, a novel antifungal 2-phenylphthalazin-2-ium scaffold as a simple analogue was designed. Most of the 30 compounds showed excellent inhibition activity against almost all eight phytopathogenic fungi, far superior to sanguinarine and chelerythrine. A third of the compounds were more active than azoxystrobin in most cases. Compounds 26 and 27 showed the highest total activity against all the fungi with EC50 means of ca. 4.6 mu g/mL. Fusarium solani showed the highest susceptibility with an EC50 mean of 3.62 mu g/mL to 19 compounds. A concentration of 25.0 mu g/mL 27 can fully control the Colletotrichum gloeosporioides infection in apples over 9 days. Electron microscopic observations showed that 27 was able to damage the structures of the hypha and cell membrane. The structure-activity relationship showed that the presence of electron-withdrawing groups on the C-ring increases the activity against most of the fungi. Thus, 2-phenylphthalazin-2-ium compounds represent promising leads for the development of novel fungicides.

Electric Literature of 767-00-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 767-00-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem